Azithromycin ultrafine powder in-situ gel eye drops and preparation method thereof
A technology of azithromycin and ultrafine powder, which is applied in the field of medicine, can solve the problems of low solubility of azithromycin and prolong residence time, and achieve the effect of improving bioavailability, prolonging residence time and reducing the chance of pollution
- Summary
- Abstract
- Description
- Claims
- Application Information
AI Technical Summary
Problems solved by technology
Method used
Image
Examples
Embodiment 1
[0026] 0.5%of Achithromycin ultra -fine powder (calculated with the actual content of Akithromycin)
[0027] 5% alginic acid
[0028] NaCl 0.9%
[0029] 0.02% citric acid
[0030] 0.03% of Nepalese ethyl ester
[0031] NaOH AQ is dissolved in an appropriate amount to sea alginic acid
[0032] Add ion water to 10ml of injection.
[0033] The specific process is:
[0034] A polymer solution: Take an injection of 8ml of de -ion water, add the prescribed alginic acid, slowly add a 5%NAOH solution under the condition of the room temperature, until it is all dissolved, at this time the pH of the solution should be close to 7.Then perform 0.22 μm microporous filter membrane pressure filtration.
[0035] B preparation of Achicidin ultra -fine powder: Applied chemical ultrasound method.A certain amount of Akithromycin ingredients are dissolved in the hydrochloric acid solution of 20ml 0.06 mol / L to make Akithromycin hydrochloride.Take a certain amount of sixteen alkyl trisidium bromide and...
Embodiment 2
[0039] Achicillin ultra -fine powder 1%(measured with the actual content of Akithromycin)
[0040] 10% alginic acid
[0041] 0.5% mannitol 0.5%
[0042] Sodium sodium sodium 0.01%
[0043] 0.01% of sulfate mercury
[0044] NaOH AQ is dissolved in an appropriate amount to sea alginic acid
[0045] Add ion water to 10ml of injection.
[0046] The specific process is:
[0047] A polymer solution: Take an injection of 8ml of de -ion water, add the prescribed alginic acid, slowly add a 5%NAOH solution under the condition of the room temperature, until it is all dissolved, at this time the pH of the solution should be close to 7.Then perform 0.22 μm microporous filter membrane pressure filtration.
[0048] B preparation of Achicidin ultra -fine powder: Apply ultrasound emulsified solvents evaporation method.A certain amount of Akithromycin was dissolved in a 100ml cup with a 10ml pyrine, and then the Achicterin solution was mixed with a certain concentration of polyethylene pyrirol.Put ...
Embodiment 3
[0052] 1.5%of Achithromycin ultra -fine powder (calculated with the actual content of Akithromycin)
[0053] 15% sea alginic acid
[0054] KCL 1%
[0056] 0.03% of benzobenbenblyzide
[0057] NaOH AQ is dissolved in an appropriate amount to sea alginic acid
[0058] Add ion water to 10ml of injection.
[0059] The specific process is:
[0060] A polymer solution: Take an injection of 8ml of de -ion water, add the prescribed alginic acid, slowly add a 5%NAOH solution under the condition of the room temperature, until it is all dissolved, at this time the pH of the solution should be close to 7.Then perform 0.22 μm microporous filter membrane pressure filtration.
[0061] B Preparation of Achicidin ultra -fine powder: Application reaction precipitation method.Accurately referred to as Achicillin ingredients dissolved in a sparse HCL of 0.05 mol / L, and prepared Azithromycin HCL solution with a concentration of 0.02 mol / L, and filtered with a filter of 0....
PUM
Property | Measurement | Unit |
---|---|---|
particle diameter | aaaaa | aaaaa |
viscosity | aaaaa | aaaaa |
Abstract
Description
Claims
Application Information
- R&D Engineer
- R&D Manager
- IP Professional
- Industry Leading Data Capabilities
- Powerful AI technology
- Patent DNA Extraction
Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.
© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com