Kiwi soft capsule preparation method with functions of regulating immunity and inhibiting tumors
A technology for regulating immunity and kiwi fruit, which is applied in capsule delivery, antineoplastic drugs, and medical preparations containing active ingredients, etc. It can solve the problems of inconvenient storage, carrying and taking, difficulty in achieving health care functions, etc., and achieve good antioxidant function , excellent and convenient anti-cancer adjuvant therapy health products, and the effect of regulating immune function
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Embodiment 1
[0021] (1) Kiwi fruit freeze-dried powder
[0022] Peel 50kg of kiwi fruit (commercially available), slice, pre-freeze to -20°C for 2 hours, turn on the vacuum pump, the vacuum degree reaches 0.1mmHg, turn off the freezer, keep the vacuum during sublimation drying, and slowly heat up the drying chamber to 20°C ℃, about 24 hours; when re-drying, raise the temperature to 25 ℃, keep it for 2 hours, freeze-dried the product, and ultrafinely pulverize it through a 200-mesh sieve at a temperature of ≤ 25 ℃.
[0023] (2) Chia polysaccharide
[0024] Decoct the kiwifruit peel in water for two times, the first time for 2 hours, the second time for 1.5 hours, combine the second decoction, filter, concentrate the filtrate to a specific gravity of 1.15, add ethanol until the alcohol content is 70% (v / v), and filter Precipitated, drained, washed once with ethanol, dried in vacuum, ultrafinely crushed and passed through a 200-mesh sieve to obtain the product.
[0025] (3) Soft capsule pre...
Embodiment 2
[0031] (1) Kiwi fruit freeze-dried powder
[0032] Peel 50kg of kiwi fruit (commercially available), slice, pre-freeze to -25°C for 3 hours, turn on the vacuum pump, the vacuum degree reaches 0.1mmHg, turn off the freezer, keep the vacuum during sublimation drying, and slowly heat up the drying room to 25°C ℃, about 18 hours; when re-drying, raise the temperature to 30 ℃, keep it for 4 hours, freeze-dried the product, ultrafinely grind it through a 250-mesh sieve, and obtain it.
[0033] (2) Chia polysaccharide
[0034] Chinese kiwifruit peel is decocted twice, the first time is 3 hours, the second time is 2 hours, the second decoction is combined, filtered, the filtrate is concentrated to a specific gravity of 1.8, and ethanol is added to the alcohol content of 90% (v / v), filtered Precipitated, drained, washed once with ethanol, dried in vacuum, ultrafinely pulverized and passed through a 250-mesh sieve.
[0035] (3) Soft capsule preparation
[0036] Kiwi fruit freeze-drie...
Embodiment 3
[0041] Effect of Kiwiguo Soft Capsules on the Phagocytosis of Peritoneal Macrophages in Mice
[0042] 1 Purpose of the experiment: To observe the effect of kiwi fruit soft capsule on the phagocytic function of peritoneal macrophages in mice.
[0043] 2 Test drugs:
[0044] Drug name: kiwi fruit soft capsule (sample of embodiment 1)
[0045] 3 experimental animals
[0046] Kunming mice, ♂ sex, 18-20g, provided by Shanghai Slack Animal Co., Ltd. Certificate number: SCXK (Shanghai) 2003-0003
[0047] 4 experimental doses
[0048] The designed experimental dosage is: 0.5g / kg; 1.5g / kg
[0049] 5 Positive Drugs
[0050] Name: Yunzhi Glycopeptide Capsules (commercially available)
[0051] Specification: 0.34g / grain
[0052] Usage and dosage: 3 capsules each time, 3 times a day.
[0053] Experimental dose: 1g / kg
[0054] 6 Administration route and capacity
[0055] Oral administration, 0.5ml / 20g.
[0056] 7 Experimental methods
[0057] The mice were randomly divided into...
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