Starch stypticum and preparation method thereof

A technology of hemostatic agent and starch, which is applied in blood diseases, surgical drugs, extracellular fluid diseases, etc. It can solve the problems of low amylopectin content, reduction of starch micropores, and insufficient water absorption, so as to inhibit bleeding, Effect of improving migration ability and reducing bleeding volume

Active Publication Date: 2012-07-18
北京爱特康医疗科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Patents 200810133097.8 and 200910051671.X use the enzyme perforation method, because the content of amylopectin is low, and there is no pre-acid hydrolysis, which reduces the micropore volume of the starch, the water absorption is not strong enough, and the hemostatic effect is not good

Method used

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  • Starch stypticum and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0015] Mill 100Kg of waxy cornstarch with a stirring ball mill to 5000 mesh, put it into the reaction tank, add 300Kg of water, and then add 0.02Kg of borax crosslinking agent, the reaction temperature is 40°C, and react for 50min; after the crosslinking reaction is completed, add 8Kg hydrochloric acid for acid hydrolysis, the acid hydrolysis reaction time is 60min, and the acid hydrolysis reaction temperature is 40°C; after the acid hydrolysis is completed, adjust the pH value to 4.0 with acetic acid, add 1Kg compound enzyme (alpha-amylase and glucoamylase each 50%) to carry out Enzymolysis, the enzymolysis reaction time is 8 hours, and the enzymolysis reaction temperature is 45°C; after the enzymolysis reaction is completed, centrifuge and filter, wash with distilled water for 3 times; Sieve; sterilize with Co60 irradiation to obtain starch hemostatic agent.

Embodiment 2

[0017] Mill 100Kg of waxy cornstarch with a stirring ball mill to 6000 mesh, put it into the reaction tank, add 200Kg of water, and then add 0.02Kg of borax cross-linking agent, the reaction temperature is 50°C, and react for 40 minutes; after the cross-linking reaction is completed, add 9Kg hydrochloric acid for acid hydrolysis, the acid hydrolysis reaction time is 30min, and the acid hydrolysis reaction temperature is 50°C; after the acid hydrolysis is completed, the pH value is adjusted to 4.5 with acetic acid, and 0.8Kg compound enzyme (50% of α-amylase and glucoamylase each) is added. Carry out enzymolysis, the enzymolysis reaction time is 10h, the enzymolysis reaction temperature is 50 ℃; After the enzymolysis reaction is completed, centrifuge and filter, wash 3 times with distilled water; Mesh sieve; sterilized by Co60 irradiation to obtain starch hemostatic agent.

Embodiment 3

[0019] Mill 50Kg of waxy corn starch to 8000 mesh with a stirring ball mill, add to the reaction tank, add 150Kg of water, and then add 0.03Kg of borax cross-linking agent, the reaction temperature is 55°C, and react for 45 minutes; after the cross-linking reaction is completed, add 6Kg hydrochloric acid for acid hydrolysis, the acid hydrolysis reaction time is 80min, and the acid hydrolysis reaction temperature is 50°C; after the acid hydrolysis is completed, the pH value is adjusted to 5.5 with acetic acid, and 0.6Kg compound enzyme (50% of α-amylase and glucoamylase each) is added. Carry out enzymolysis, the enzymolysis reaction time is 7h, the enzymolysis reaction temperature is 50 ℃; after the enzymolysis reaction is completed, centrifuge and filter, wash with distilled water 3 times; Mesh sieve; sterilized by Co60 irradiation to obtain starch hemostatic agent.

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Abstract

The invention discloses a starch stypticum and a preparation method thereof, belonging to the field of medical preparations. The preparation method comprises the following steps: refining waxy maize starch to 4,000 to 10,000 meshes; centrifugally filtering after crosslinking, acidolysis and enzymolysis are completed; cleaning with distilled water; blasting and drying at constant temperature untilthe weight is constant; crushing, and screening through a 200-mesh screen; radiating by Co60 to disinfect to prepare the starch stypticum. The water absorption rate of the starch stypticum prepared by adopting the method is 2 to 3 times that of the conventional styptic materials, the starch stypticum can quickly stop bleeding in actual application, has quick styptic function in great vessel hemorrhage, even massive bleeding wound surface, and can be widely applied to surgeries of cardiothoracic and vascular surgery department, hepatobiliary surgery department, orthopedics department, general surgery department, obstetrics and gynecology department, urology surgery department and ear-nose-throat department and the like.

Description

technical field [0001] The invention relates to a starch hemostatic agent and a preparation method thereof, belonging to the field of medical pharmacies. Background technique [0002] At home and abroad, we have been committed to the research and development of hemostatic materials that can quickly stop bleeding in parenchymal organs and have no effect on their functions. Currently, the clinically used hemostatic materials include: gelatin sponge or powder, oxidized regenerated cellulose, fibrinogen, thrombin, artificial hydrocoagulant Gum and polysaccharide products. These products are slow in hemostasis and unsatisfactory in effect. The Arista hemostatic powder (U.S. Patent US6060461) of Medfor Company in the United States is starch microspheres produced from potatoes, which has shown good safety and good hemostatic effect in clinical applications, but it is expensive. The ultrastructure shows that Arista hemostatic powder is a microsphere with a crack structure on the s...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/718A61P7/04A61P41/00
Inventor 王美岭
Owner 北京爱特康医疗科技有限公司
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