Method and device for synthesizing compound by solid phase reaction

A technology of solid phase reaction and solid reactants, which is applied in the field of solid phase reaction synthesis of compounds, can solve problems such as narrow application range, high cost, and wear of grinding balls, and achieve the effects of wide application range, fast reaction speed, and low cost

Inactive Publication Date: 2011-09-28
楚士晋
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0003] But for a long time, because the traditional solid-state reaction materials mainly involve some inorganic solids with high melting point, such as silicates, oxides, metal alloys, etc., these materials generally have the characteristics of three-dimensional network structure, small atomic gap and strong chemical bond. , the solid-phase synthesis reaction is mostly carried out at high temperature. First, the reaction material is calcined,...

Method used

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  • Method and device for synthesizing compound by solid phase reaction
  • Method and device for synthesizing compound by solid phase reaction

Examples

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Effect test

Embodiment 1

[0032] Solid Phase Synthesis of Isopropylidene p-Nitrophenylmalonate

[0033] Use isopropylidene malonate and p-nitrobenzaldehyde as raw materials: uniformly mix according to the ratio of the substances of 1:1, the mixed material enters the supersonic nozzle through negative pressure ejection, and expands rapidly after accelerating in the nozzle A supersonic mixing system is generated, followed by violent friction and collision in the reactor, and finally hits a fixed target at high speed, and then merges with the airflow and enters the circulation system at a speed of 30 m / s. The particles in the reaction system settle, enrich and enter the nozzle again, After circulating in the generator for a period of time, take samples for analysis, then fully wash with 65°C distilled water three times, drain, recrystallize with 95% ethanol, and dry in a vacuum dryer (40°C) for 8 hours to obtain the white target product Isopropylidene p-nitrophenylmalonate.

[0034] When preparing isopro...

Embodiment 2

[0036] Solid Phase Synthesis of Isopropylidene p-Hydroxyphenylmalonate

[0037]Using isopropylidene malonate and p-hydroxybenzaldehyde as raw materials: uniformly mixed according to the ratio of the substances in the amount of 1:1, the mixed material enters the supersonic nozzle through negative pressure ejection, and expands rapidly after accelerating in the nozzle to produce The supersonic mixing system, followed by violent friction and collision in the reactor, finally hits the fixed target at high speed, and then merges with the airflow and enters the circulation system at a speed of 30 m / s. The particles in the reaction system settle, enrich and enter the nozzle again. After circulating in the container for a period of time, take a sample for analysis, then fully wash with 65°C distilled water three times, drain, recrystallize with 95% ethanol, and dry in a vacuum dryer (40°C) for 8 hours to obtain the white target product .

[0038] When preparing isopropylidene p-nitro...

Embodiment 3

[0040] Preparation of ultrafine calcium carbonate.

[0041] Mix 70-mesh anhydrous calcium chloride (0.1380 kg) and sodium carbonate (0.1363 kg) at a molar ratio of 1:1 to make them collide with a fixed target in the reactor at 3 times the speed of sound, and react in the reaction generator. After circulating the reaction for a period of time, the mixture was fully washed 3 times with distilled water, then 2 times with absolute ethanol, and dried to obtain superfine calcium carbonate.

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Abstract

The invention relates to a method for synthesizing a compound by solid phase reaction, which comprises the following steps that: 1, solid reactants are mixed and are accelerated to reach supersonic speed by high-speed carrier airflow, so that the solid reactants have high kinetic energy; 2, a microwave field is arranged in the motion process of the solid reactants, so that the solid reactants pass through the microwave field to enhance the molecular thermal motion of the reactants and improve activity; and 3, the solid reactants are synthesized, namely A, the solid reactants which moves at a high speed impact a fixed target circularly, and are crushed gradually to form solid reactants with molecular grain diameters; and B, the solid reactants with the molecular grain diameters impact a target head at the high speed, so that the kinetic energy is converted into internal energy, molecular chemical bonds are broken to be decomposed into ions, and negative ions and positive ions recombineto form bonds to synthesize the target compound. By the method, the high-temperature limit of the conventional solid phase reaction is broken through, so that the solid phase reaction can be performed at normal temperature. Therefore, a new technical route is provided for the synthesis of the compound, the application range is wide, the reaction speed and yield are high, cost is low, and obvious economic and environment-friendly effects are achieved.

Description

technical field [0001] The invention relates to a method for synthesizing compounds, in particular to a method for synthesizing compounds by solid-phase reaction and a device thereof. Background technique [0002] At present, environmental pollution and excessive energy consumption are causing more and more harm to the earth and human beings. While developing the economy, people are also actively facing how to overcome environmental pollution and protect our ecological balance. In the past ten years, due to the fact that the traditional chemical reaction is carried out in solution or gas phase, the reaction requires high energy consumption, long time, serious environmental pollution and complex process, so more and more people are turning their attention to Utilized solid-phase chemical reactions. Solid phase reactions are those reactions involving solid substances. That is to say, the reactant must be a reaction of solid matter to be called a solid state reaction. Solid...

Claims

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Application Information

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IPC IPC(8): B01J19/12C07D319/06C01F11/18
Inventor 楚士晋彭汝芳金波李鸿波谭碧生蔡艳华袁邦群
Owner 楚士晋
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