Medicine for treating oral diseases and preparation method thereof

A technology for oral diseases and medicines, which is applied in the field of medicines for the treatment of oral diseases and their preparation, can solve the problems of ineffective treatment methods for oral diseases, and achieve the effects of improving drug efficacy, convenient use and improving taste.

Active Publication Date: 2011-11-02
XINJIANG CICONHABO UYGUR MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there is no effective treatment for oral diseases. For most patients, topical or syste

Method used

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  • Medicine for treating oral diseases and preparation method thereof
  • Medicine for treating oral diseases and preparation method thereof
  • Medicine for treating oral diseases and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Example Embodiment

[0014] Example 1 (Taking 1000 tablets as the base, preparing lozenges and enumerating them in a table)

[0015] a. Crush the selected gallbladder medicinal materials to 5 meshes, extract once with 5 times the amount of solvent aqueous solution, temperature 30°C, extraction time 1 hour, recover the solvent, concentrate, and vacuum dry to obtain dry extract, which is crushed into powder , Pass a 60-mesh drug sieve to obtain a crude extract;

[0016] b. The crude gallbladder extract was dissolved in an aqueous solution, adsorbed with a macroporous resin, and then eluted with an organic reagent ethanol aqueous solution with a concentration of 0-95%. The eluate was collected, and the eluate was concentrated under reduced pressure and dried. The effective part of gallbladder tannin is obtained, and the total tannin content is 50% based on the weight of the dry product;

[0017] c. Then use preparative liquid chromatography and countercurrent chromatography to obtain the active ingredients...

Example Embodiment

[0023] Example 2 (Preparation of orally disintegrating tablets and listing them in a table)

[0024] a. Crush the selected gallbladder medicinal materials to 20 meshes, extract twice with 8 times the amount of solvent, temperature 50℃, each extraction time 2 hours, combine the extracts, recover the solvent, concentrate, and vacuum dry to get dry leaching The ointment is crushed into powder and passed through an 80-mesh drug sieve to obtain a crude extract;

[0025] b. The crude gallbladder extract was dissolved in 60% ethanol aqueous solution, adsorbed by dextran gel, and eluted with 0-95% methanol aqueous solution in turn, collected the eluate, concentrated under reduced pressure, and dried , That is, the effective part of gallbladder tannin is obtained, and the total tannin content is 60% calculated by dry weight;

[0026] c. Then, the active ingredients gallic acid, meta-digallic acid, methyl gallate, 1,2,3,6-tetra-O-galloyl-β-D-glucose, 1,2, 3,4,6-Penta-O-galloyl-β-D-glucose, e...

Example Embodiment

[0032] Example 3 (Preparation of oral effervescent tablets and enumerate them in a table)

[0033] a. Crush the selected gallbladder medicinal materials to 40 meshes, extract 3 times with 10 times the amount of solvent, temperature 70℃, each extraction time 3 hours, combine the extracts, recover the solvent, concentrate, spray dry, and get dry leaching The ointment is crushed into powder and passed through a 100-mesh drug sieve to obtain a crude extract;

[0034] b. The crude gallbladder extract is dissolved in 40% ethanol aqueous solution, adsorbed with polyamide, and then eluted with 0-95% ethanol solution in turn. Collect the eluate, concentrate the eluate under reduced pressure, and dry it. Obtain the effective part of gallbladder tannin, which is 70% of total tannin calculated by dry weight;

[0035] c. Then, the active ingredients gallic acid, meta-digallic acid, methyl gallate, 1,2,3,6-tetra-O-galloyl-β-D-glucose, 1,2, 3,4,6-Penta-O-galloyl-β-D-glucose, etc., the content is ...

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Abstract

The invention relates to a medicine in which a Uigur medicine, namely gallnut is taken as a raw medicine and which is used for treating oral diseases, and a preparation method thereof. The medicine is prepared by the following steps of: obtaining a crude gallnut extract by a solvent extraction method, further obtaining effective parts and effective components of the gallnut by a macroporous resinmethod or a gel chromatography method or an ultrafiltration membrane method, and adding pharmaceutically acceptable excipients to obtain buccal tablets, orally disintegrating tablets, oral effervescent tablets, and a film agent. In the medicine, the effective parts and the effective components, which are used for treating oral diseases, of the gallnut are enriched by modern separation and purification technologies, so that the utilization rate of functional compositions is improved, the law of absorption, distribution and metabolism of medicines in human bodies is met, and the medicinal effect is improved. Through pharmacological experiments, the effective parts and the effective components of the gallnut have the effects of resisting inflammation, easing pain, resisting bacteria and oxidation, immunoregulating and the like, can quickly repair dental ulcer and accelerate the healing of dental ulcer, and can effectively resist oral diseases such as gingivitis, ozostomia, stinking throat, mouth and tongue sore and the like caused by common pathogenic bacteria in oral cavities.

Description

technical field [0001] The invention relates to a medicine for treating oral diseases and a preparation method thereof. Background technique [0002] The pathological phenomenon of the oral cavity in the event of damage by external physical and chemical factors, invasion of pathogens, abnormal dental and maxillofacial development, and systemic diseases. There are many types of oral diseases, which originate in the oral cavity. According to the latest oral epidemiological survey report, although the oral health status of the whole people in my country has been gradually improved in recent years, the situation of prevention and treatment of high-incidence diseases such as oral ulcers, tooth decay, and periodontal disease is very severe, and the prevalence rate of oral diseases is as high as 97.6%. Although the occurrence of stomatopathy is not fatal, it shows as pain, festering, and recurrent outbreaks, which directly affects people's work, study and labor sometimes. Regardle...

Claims

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Application Information

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IPC IPC(8): A61K35/64A61P1/02
Inventor 斯拉甫·艾白霍仕霞李治建
Owner XINJIANG CICONHABO UYGUR MEDICINE
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