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Medicine for treating oral diseases and preparation method thereof

A technology for oral diseases and medicines, which is applied in the field of medicines for the treatment of oral diseases and their preparation, can solve the problems of ineffective treatment methods for oral diseases, and achieve the effects of improving drug efficacy, convenient use and improving taste.

Active Publication Date: 2011-11-02
XINJIANG CICONHABO UYGUR MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there is no effective treatment for oral diseases. For most patients, topical or systemic medication can reduce side effects and adverse reactions such as pain caused by oral diseases.

Method used

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  • Medicine for treating oral diseases and preparation method thereof
  • Medicine for treating oral diseases and preparation method thereof
  • Medicine for treating oral diseases and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0014] Embodiment 1 (with 1000 as base number, prepare buccal tablet, and enumerate in the mode of table)

[0015] a. Grind the screened gallic medicinal material to 5 meshes, extract once with 5 times the amount of solvent aqueous solution, the temperature is 30°C, the extraction time is 1 hour, the solvent is recovered, concentrated, and vacuum-dried to obtain a dry extract, which is crushed into powder , through a 60-mesh drug sieve to obtain a crude extract;

[0016] b. Dissolve the crude gallic extract in an aqueous solution, absorb it with a macroporous resin, and then elute it with an organic reagent ethanol solution with a concentration of 0-95%, collect the eluent, concentrate the eluent under reduced pressure, and dry it. The effective part of gallotannin is obtained, which contains 50% of total tannin by weight of dry product;

[0017] c, then further use preparative liquid chromatography and countercurrent chromatography to obtain the effective ingredients of gall...

Embodiment 2

[0023] Embodiment 2 (preparation of orally disintegrating tablets, and enumerating in the form of a table)

[0024] a. Crush the screened gallic medicinal material to 20 meshes, extract twice with 8 times the amount of solvent, at a temperature of 50°C, and extract for 2 hours each time, combine the extracts, recover the solvent, concentrate, and dry in vacuum to obtain dry infusion Paste, crushed into powder, passed through 80-mesh medicine sieve to obtain crude extract;

[0025] b. Dissolve the crude gallic extract with 60% ethanol aqueous solution, absorb it with Sephadex gel, elute with 0-95% methanol aqueous solution successively, collect the eluent, concentrate the eluent under reduced pressure, and dry , to obtain the effective fraction of gallic tannin, which contains 60% of total tannin by weight of dry product;

[0026] c, and then further prepare the active ingredients gallic acid, m-digallic acid, methyl gallate, 1,2,3,6-tetra-O-galloyl-β-D-glucose, 1,2, 3,4,6-Pe...

Embodiment 3

[0032] Embodiment 3 (preparation oral effervescent tablet, and enumerates in the mode of table)

[0033] a. Crush the screened gallic medicinal material to 40 mesh, extract 3 times with 10 times the amount of solvent at 70°C, and extract for 3 hours each time, combine the extracts, recover the solvent, concentrate, and spray dry to obtain dry infusion Paste, crushed into powder, passed through a 100-mesh medicine sieve to obtain crude extract;

[0034]b. Dissolve the crude gallic extract with 40% ethanol aqueous solution, absorb it with polyamide, elute with ethanol solution with a concentration of 0-95% successively, collect the eluent, concentrate the eluent under reduced pressure, and dry, that is The effective parts of gallic tannin are obtained, which contain 70% of total tannin by weight of dry product;

[0035] c, and then further prepare the active ingredients gallic acid, m-digallic acid, methyl gallate, 1,2,3,6-tetra-O-galloyl-β-D-glucose, 1,2, 3,4,6-Penta-O-galloy...

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Abstract

The invention relates to a medicine in which a Uigur medicine, namely gallnut is taken as a raw medicine and which is used for treating oral diseases, and a preparation method thereof. The medicine is prepared by the following steps of: obtaining a crude gallnut extract by a solvent extraction method, further obtaining effective parts and effective components of the gallnut by a macroporous resinmethod or a gel chromatography method or an ultrafiltration membrane method, and adding pharmaceutically acceptable excipients to obtain buccal tablets, orally disintegrating tablets, oral effervescent tablets, and a film agent. In the medicine, the effective parts and the effective components, which are used for treating oral diseases, of the gallnut are enriched by modern separation and purification technologies, so that the utilization rate of functional compositions is improved, the law of absorption, distribution and metabolism of medicines in human bodies is met, and the medicinal effect is improved. Through pharmacological experiments, the effective parts and the effective components of the gallnut have the effects of resisting inflammation, easing pain, resisting bacteria and oxidation, immunoregulating and the like, can quickly repair dental ulcer and accelerate the healing of dental ulcer, and can effectively resist oral diseases such as gingivitis, ozostomia, stinking throat, mouth and tongue sore and the like caused by common pathogenic bacteria in oral cavities.

Description

technical field [0001] The invention relates to a medicine for treating oral diseases and a preparation method thereof. Background technique [0002] The pathological phenomenon of the oral cavity in the event of damage by external physical and chemical factors, invasion of pathogens, abnormal dental and maxillofacial development, and systemic diseases. There are many types of oral diseases, which originate in the oral cavity. According to the latest oral epidemiological survey report, although the oral health status of the whole people in my country has been gradually improved in recent years, the situation of prevention and treatment of high-incidence diseases such as oral ulcers, tooth decay, and periodontal disease is very severe, and the prevalence rate of oral diseases is as high as 97.6%. Although the occurrence of stomatopathy is not fatal, it shows as pain, festering, and recurrent outbreaks, which directly affects people's work, study and labor sometimes. Regardle...

Claims

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Application Information

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IPC IPC(8): A61K35/64A61P1/02
Inventor 斯拉甫·艾白霍仕霞李治建
Owner XINJIANG CICONHABO UYGUR MEDICINE
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