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Preparation method of dendrimer stable bismuth sulfide nanoparticles

A technology of dendrimer and amine dendrimer, applied in the field of preparation of bismuth sulfide nanoparticles, can solve problems such as no related reports, and achieve the effect of preventing aggregation

Inactive Publication Date: 2011-11-16
DONGHUA UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The results of searching domestic and foreign literature and patents on bismuth sulfide nanoparticles show that there is no relevant report on the preparation method of bismuth sulfide nanoparticles stabilized by dendrimers

Method used

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  • Preparation method of dendrimer stable bismuth sulfide nanoparticles
  • Preparation method of dendrimer stable bismuth sulfide nanoparticles
  • Preparation method of dendrimer stable bismuth sulfide nanoparticles

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0054] (1) Prepare 25 mL of dilute acetic acid solution with a volume fraction of 10%. The fourth generation polyamidoamine dendrimer (G4.NGlyOH) with a dry weight of 40.00 mg at the end of the hydroxyl group was dissolved in 8 mL of 10% dilute acetic acid solution, and ultrasonically treated to make it fully dissolved and uniform. Take Bi(NO 3 ) 3 ·5H 2 10.68mg of O powder was dissolved in 5.34mL of 10% dilute acetic acid solution, ultrasonically treated to fully dissolve it, and then added to the G4.NGlyOH solution, stirred for 1 hour, and the two were fully mixed.

[0055] (2) Take Na 2 S·9H 2 O solid 2g, dropwise adding therein is the dilute acetic acid solution of 10% by volume fraction, the H produced 2 S gas was continuously fed into the solution in step (1), and the reaction was stirred at room temperature for 1 h under the condition of nitrogen protection. After the reaction was completed, the stirring was continued for 8 h, and then the reaction product was dia...

Embodiment 2

[0060] (1) Prepare 25 mL of dilute acetic acid solution with a volume fraction of 10%. The fourth-generation polyamidoamine dendrimer (G4.NGlyOH) with a dry weight of 30.00 mg at the end of the hydroxyl group was dissolved in 10 mL of 10% dilute acetic acid solution, and ultrasonically treated to fully dissolve it evenly. Take Bi(NO 3 ) 3 ·5H 2O powder 16.02mg, dissolved in 10.68mL of 10% dilute acetic acid solution, ultrasonic treatment to make it fully dissolved, then added to G4.NGlyOH solution, stirred for 1.5h, so that the two were fully mixed.

[0061] (2) will Bi(NO 3 ) 3 ·5H 2 O1.5 times the amount of substance H 2 S gas was continuously fed into the solution in step (1), and the reaction was stirred at room temperature for 1.5 h under the condition of nitrogen protection. After the reaction was completed, the stirring was continued for 9 h, and then the reaction product was dialyzed 3 times in 4 L of PBS buffer solution and 3 times in 4 L of ultrapure water wit...

Embodiment 3

[0066] (1) Prepare 25 mL of dilute acetic acid solution with a volume fraction of 10%. 20.00 mg of the fourth-generation polyamidoamine dendrimer (G4.NGlyOH) with a hydroxyl terminal at the end was dissolved in 2.86 mL of 10% dilute acetic acid solution, and ultrasonically treated to make it fully dissolved and uniform. Take Bi(NO 3 ) 3 ·5H 2 21.36mg of O powder was dissolved in 8.54mL of 10% dilute acetic acid solution, sonicated to make it fully dissolved and uniform, then added to the G4.NGlyOH solution, stirred for 2 hours, and the two were fully mixed.

[0067] (2) Take Na 2 S·9H 2 O solid 2.5g, wherein dropwise adding is the dilute acetic acid solution of 20% volume fraction, the H produced 2 S gas was continuously fed into the solution in step (1), and the reaction was stirred at room temperature for 2 h under the condition of nitrogen protection. After the reaction was completed, the stirring was continued for 9 h, and then the reaction product was dialyzed 3 tim...

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Abstract

The invention relates to a preparation method of dendrimer stable bismuth sulfide nanoparticles. The preparation method comprises: (1) preparing a diluted acetic acid solution of hydroxyl-terminated fourth-generation polyamide-amine dendrimer and preparing a bismuth salt diluted acetic acid solution; and (2) mixing the diluted acetic acid solution of hydroxyl-terminated fourth-generation polyamide-amine dendrimer with the bismuth salt diluted acetic acid solution, introducing H2S gas, reacting under the protection of nitrogen gas for 1-2 hours, carrying out dialysis after the reaction is finished, and performing freeze-drying to obtain the dendrimer stable bismuth sulfide nanoparticles. The preparation method provided by the invention is simple to operate and has mild reaction conditions; and the prepared dendrimer stable bismuth sulfide nanoparticles have the advantages of narrow particle size distribution, good dispersion property and no agglomeration, can be potentially used in CT (computed tomography) imaging diagnosis, and has been successfully applied to the rabbit in-vivo imaging.

Description

technical field [0001] The invention belongs to the field of preparation of bismuth sulfide nanoparticles, in particular to a preparation method of dendrimer-stabilized bismuth sulfide nanoparticles. Background technique [0002] Due to their special size, nanomaterials have many peculiar physical and chemical properties. In recent years, they have been widely used in the fields of medicine, chemical industry, textile, aerospace, military and electronics. Among them, in the field of biomedicine, nanomaterials are used for drug delivery, cell separation, medical imaging, and targeted diagnosis and treatment of cancer. In the field of nanomaterials, bismuth sulfide nanomaterials are widely used in many fields such as optoelectronics, conduction, sensing, and biochemistry due to their very different properties from bulk materials. In addition, due to the high atomic number and X-ray attenuation performance of bismuth element, bismuth sulfide nanoparticles can be used as CT con...

Claims

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Application Information

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IPC IPC(8): C01G29/00B82Y30/00
Inventor 史向阳方逸彭琛
Owner DONGHUA UNIV
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