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Cefdinir capsule and preparation method thereof

A technology of dini capsule and cefdinir, which is applied in the field of cefdinir capsule and its preparation, can solve the ineffectiveness of Pseudomonas aeruginosa, Pseudomonas cepacia, Acinetobacter, enterococcus and Listeria monocytogenes, It is also ineffective against Legionella and anaerobic bacteria, including Bacteroides and Clostridium, and achieves the effects of good water solubility, simple preparation process and strong operability

Inactive Publication Date: 2011-12-07
SHIJIAZHUANG NO 4 PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

As a third-generation cephalosporin, cefdinir has broad-spectrum antibacterial activity against G+ and G-, and can inhibit 90% to 100% of clinically isolated bacteria, such as methicillin-sensitive Staphylococcus aureus (MSSA), grapevine epidermidis cocci (MSSE), streptococci (including Streptococcus pneumoniae), Haemophilus influenzae, Klebsiella pneumoniae, Moraxella catarrhalis, Escherichia coli, even to Neisseria gonorrhoeae, Branham catarrhalis, indole Positive Proteus also has a good effect, but it is ineffective against Pseudomonas aeruginosa, Pseudomonas cepacia, Acinetobacter, Enterococcus and Listeria, and has no effect on Legionella and anaerobic bacteria, including Bacteroides and Clostridium Bacillus group is also invalid

Method used

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  • Cefdinir capsule and preparation method thereof
  • Cefdinir capsule and preparation method thereof
  • Cefdinir capsule and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0043]

[0044] (1) pass the raw and auxiliary materials through a 100-mesh sieve for subsequent use;

[0045] (2) Weigh according to the prescription amount, and mix cefdinir and auxiliary materials evenly;

[0046] (3) Intermediate detection;

[0047] (4) Capsule filling, polishing, and packaging to obtain cefdinir capsules with a specification of 100 mg (calculated as cefdinir).

Embodiment 2

[0049]

[0050](1) The raw material, croscarmellose sodium, and poloxamer are respectively passed through a 100-mesh sieve for subsequent use;

[0051] (2) Weigh the raw and auxiliary materials according to the prescription amount, mix cefdinir with croscarmellose sodium and poloxamer evenly, add 40% ethanol in an appropriate amount to make a soft material, granulate with a 40-mesh sieve, 45-55 Dry between, 40 mesh sieves granulate, add the magnesium stearate of recipe quantity;

[0052] (3) Intermediate detection;

[0053] (4) Capsule filling, polishing, and packaging to obtain cefdinir capsules with a specification of 100 mg (calculated as cefdinir).

Embodiment 3

[0055]

[0056] (1) pass the raw and auxiliary materials through a 100-mesh sieve for subsequent use;

[0057] (2) Weigh according to the prescription amount, and mix cefdinir and auxiliary materials evenly;

[0058] (3) Intermediate detection;

[0059] (4) Capsule filling, polishing, and packaging to obtain cefdinir capsules with a specification of 50 mg (calculated as cefdinir).

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Abstract

The invention provides a cefdinir capsule and a preparation method thereof. The capsule is composed of cefdinir as the main agent and an appropriate amount of auxiliary materials such as a filler, a disintegrating agent, a lubricant, a solubilizer, and the like. The preparation method: separate the raw and auxiliary materials Pass through a 100-mesh sieve and mix evenly and directly fill or granulate and fill. The capsule of the present invention has simple process, stable quality and good dissolution behavior, and is suitable for industrial production.

Description

technical field [0001] The invention belongs to the field of pharmaceutical preparations and relates to a cefdinir capsule and a preparation method thereof. The capsule has the advantages of simple process, stable quality and quick effect. Background technique [0002] Cefdinir (cefdinir) is the third-generation oral cephalosporin developed by Fujisawa Company in Japan. It not only maintains high stability to β-lactamase, but also improves the performance of third-generation cephalosporins such as cefixime. It only has a strong effect on G-bacteria, but has a poor effect on G+ bacteria. It has the characteristics of broad antibacterial spectrum, high curative effect and low toxicity. It was first launched in Japan in December 1991 under the product name Cefzon. In December 1997, it was approved by the FDA to go on the market in the United States under the trade name of Omnicef. It went on the market in South Korea in 1999, and in 2001, the Cefdinir Capsules produced by Tia...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/48A61K31/546A61K47/38A61K47/34A61P31/04
Inventor 杨帆李彪张海苹刘新张建维表亚囡孙伶
Owner SHIJIAZHUANG NO 4 PHARMA
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