A kind of preparation method of amoxicillin sodium
A technology of amoxicillin sodium and amoxicillin, applied in the field of drug synthesis, can solve the problems of unfavorable labor protection and environmental protection, complex solvent system, strong toxic and side effects, etc., and achieves improved dissolution rate, reduced residual content, and small toxic and side effects. Effect
- Summary
- Abstract
- Description
- Claims
- Application Information
AI Technical Summary
Problems solved by technology
Method used
Examples
Embodiment 1
[0023] (1) Preparation of acid anhydride: In dichloromethane, add hydroxydung salt, then add dimethylacetamide, pyridine and 1 / 3 pivalic acid, keep the temperature at -20°C, add pivaloyl chloride, keep the temperature and stir Make the hydroxydung salt dissolve clear for later use; add 2 / 3 special acid, the proportion of parts by weight of the components is: 3 parts of dichloromethane, 1 part of hydroxydung salt, 1 part of dimethylacetamide, 1 part of pyridine , 3 parts of pivalic acid, 3 parts of pivaloyl chloride;
[0024] (2) Preparation of 6-APA solution: Dissolve 6-APA in dichloromethane, stir at room temperature, add 1 / 2 triethylamine and purified water, cool to 0°C, add 1 / 2 triethylamine, wait for 6 -After the APA is completely dissolved, it is cooled for later use; the weight ratio of the components is: 1 part of 6-APA, 1 part of dichloromethane, 1 part of triethylamine, and 1 part of purified water;
[0025] (3) Condensation: transfer the 6-APA salt solution into the...
Embodiment 2
[0030] (1) Preparation of amoxicillin solution, in absolute ethanol, add the amoxicillin prepared in Example 1, then add diisopropylamine, keep the temperature at 10-15° C., amoxicillin is completely dissolved, add gac, and Carbon-removal filtration and sterilization filtration, and the pipeline through which the reaction liquid passes during the filtration is rinsed with absolute ethanol, and the filtrate and washing liquid are combined; the specific weight ratio is: 1 part of amoxicillin, 4 parts of absolute ethanol, diiso Propylamine 0.5 part;
[0031] (2) Preparation of sodium isooctanoate absolute ethanol solution: Add sodium isooctanoate to absolute ethanol to dissolve it completely, keep the temperature at 10-15°C, add activated carbon, filter through carbon removal and sterilize, and use anhydrous The pipeline through which the reaction liquid passes through ethanol flushing and filtration, and the filtrate and washing liquid are combined; the specific weight ratio is:...
Embodiment 3
[0034] (1) Preparation of amoxicillin solution, in absolute ethanol, add the amoxicillin prepared in Example 1, then add diisopropylamine, keep the temperature at 10-15° C., amoxicillin is completely dissolved, add gac, and Carbon-removal filtration and sterilization filtration, and the pipeline through which the reaction liquid passes through the filter is rinsed with absolute ethanol, and the filtrate and washing liquid are combined; the specific weight ratio is: 1 part of amoxicillin, 6 parts of absolute ethanol, diiso 0.3 parts of propylamine;
[0035] (2) Preparation of sodium isooctanoate absolute ethanol solution: Add sodium isooctanoate to absolute ethanol to dissolve it completely, keep the temperature at 10-15°C, add activated carbon, filter through carbon removal and sterilize, and use anhydrous The pipeline through which the reaction liquid passes through ethanol washing and filtration, and the filtrate and washing liquid are combined; the specific weight ratio is:...
PUM
Abstract
Description
Claims
Application Information
- R&D Engineer
- R&D Manager
- IP Professional
- Industry Leading Data Capabilities
- Powerful AI technology
- Patent DNA Extraction
Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.
© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com