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A kind of gel patch containing curcumin and bletilla striata gum and preparation method thereof

A technology of curcumin and bletilla striata gum, which is applied in the direction of medical preparations containing active ingredients, medical preparations with non-active ingredients, and pharmaceutical formulas, to achieve the effects of reducing irritation, promoting transdermal absorption and sustained release, and enhancing drug efficacy

Active Publication Date: 2011-12-21
山东福阳科技发展有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

And the curcumin transdermal drug delivery preparation, the key problem that exists is how to ensure the stability of medicine, the transdermal rate of medicine and the adhesion property of patch

Method used

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  • A kind of gel patch containing curcumin and bletilla striata gum and preparation method thereof
  • A kind of gel patch containing curcumin and bletilla striata gum and preparation method thereof
  • A kind of gel patch containing curcumin and bletilla striata gum and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] [Example 1] Preparation of Bletilla striata gum

[0035]Weigh about 20g of Bletilla striata powder, add 240mL of distilled water, heat in a water bath to 50°C and soak for heat preservation, stir and extract for 1 hour, filter through four layers of gauze to obtain the extract. Add about 80-120ml of distilled water to the dregs and repeat the extraction twice according to the above method, combine the filtrates three times, concentrate to half the volume, add 95% ethanol to make the alcohol content reach 70wt%, at this time, a large amount of white precipitates are precipitated rapidly, centrifuged, and recovered Ethanol, collect the precipitate, wash 3 times with a small amount of ethanol, evaporate the ethanol, and dry at about 80°C to obtain about 5.6g of Bletilla striata gum.

Embodiment 2

[0036] [Example 2] Preparation of a gel patch containing curcumin and bletilla striata gum

[0037] prescription:

[0038] components

Dosage (g)

effect

curcumin

0.4

active ingredient

Bletilla Gum

2.5

active ingredient, adhesive

Polyacrylic acid

3.0

Skeleton material, adhesive

Polyvinylpyrrolidone (PVP)

0.8

substrate, adhesive

Polyvinyl alcohol (PVA)

0.3

substrate, adhesive

Hypromellose (HPMC)

0.2

substrate, adhesive

Glycerin

15.0

base, humectant

Propylene Glycol

15.0

base, humectant

polyethylene glycol

5.0

base, humectant

Aluminum hydroxide (Al(OH) 3 )

0.1

matrix, crosslinking agent

water

57.7

matrix

Total

100

[0039] Preparation:

[0040] 1) Preparation of matrix: According to the dosage and proportion of the above prescription, mix Bletilla striata gum, glyc...

Embodiment 3

[0043] [Example 3] Preparation of a gel patch containing curcumin and bletilla striata gum

[0044] prescription:

[0045] components

Dosage (g)

effect

curcumin

0.4

active ingredient

Bletilla Gum

2.0

active ingredient, adhesive

PVP k-30

4.0

solid dispersion material

Polyacrylic acid

4.0

Skeleton material, adhesive

Polyvinylpyrrolidone (PVP)

0.6

substrate, adhesive

Polyvinyl alcohol (PVA)

0.1

substrate, adhesive

Hypromellose (HPMC)

0.3

substrate, adhesive

Glycerin

25.0

base, humectant

Propylene Glycol

15.0

base, humectant

polyethylene glycol

10.0

base, humectant

Aluminum hydroxide

0.2

matrix, crosslinking agent

water

38.4

matrix

Total

100

[0046] Preparation:

[0047] 1) Preparation of curcumin solid dispersion: Dissolve curcumin in an appropriat...

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PUM

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Abstract

The invention provides a gel plaster containing curcumin and bletilla hyacinthina gum, which comprises the following components in parts by weight: 0.2-0.5 part of curcumin, 1.0-2.5 parts of bletilla hyacinthina gum, 2.0-5.0 parts of polyacrylic acid, 0.4-1.4 parts of adhesive, 25.0-65.0 parts of humectant, 0.1-0.2 part of aluminum hydroxide, 0-5.0 parts of solid dispersion material, 0-1.5 parts of permeation promoter and 35.0-58.0 parts of water. The adhesive is selected from polyvinylpyrrolidone, hydroxypropyl methylcellulose, polyvinyl alcohol and the like; the humectant is selected from glycerol, propylene glycol, polyethylene glycol and the like; the solid dispersion material is selected from polyvinylpyrrolidone, mannitol, polyethylene glycol, poloxamer and the like; and the permeation promoter is selected from hydroxypropyl-beta-cyclodextrin, borneol, pennyroyal, olive oil and the like. The curcumin in the gel plaster can be transdermally absorbed and slowly and continuously released, and can stably be taken for a long time; and the bletilla hyacinthina gum can protect the skin, and reduce the irritation of the drugs to the skin.

Description

technical field [0001] The invention relates to the field of pharmaceutical preparations, in particular to a gel patch containing curcumin and bletilla striata gum and a preparation method thereof. Background technique [0002] Curcumin is a natural pigment mainly derived from the rhizome of Curcuma longa L., a plant in the ginger family, and is the main active ingredient in turmeric. Modern pharmacological studies have shown that curcumin has physiological functions and effects such as choleretic, hypolipidemic, anti-inflammatory, anti-rheumatic, antibacterial, anti-cancer, anti-oxidation, and scavenging free radicals, and can be widely used in the fields of medicine, food, and cosmetics (Mei Quan Xi et al., Pharmacological Handbook of Modern Chinese Medicine, China Press of Traditional Chinese Medicine, 1998, 490-491). Yet curcumin has instability and water insolubility, is easy to fade in air, and existing pharmaceutical dosage form is mainly injection preparation, micro...

Claims

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Application Information

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IPC IPC(8): A61K36/898A61K9/70A61K47/32A61K47/34A61K47/36A61K47/38A61K47/40A61K47/42A61P19/02A61P35/00A61K31/12
Inventor 高振坤张晓丽王建夺
Owner 山东福阳科技发展有限公司
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