Traditional Chinese medicine granules for treating skin diseases related to blood-heat-yang floating syndrome and preparation thereof

A technology of traditional Chinese medicine granules and raw materials, applied in skin diseases, medical preparations containing active ingredients, drug combinations, etc., can solve the problems of insignificant clinical efficacy, lack of traditional Chinese medicine preparations, inconvenience, etc., and achieve safety without obvious side effects, Good economic benefits, obvious anti-itching effect

Active Publication Date: 2011-12-28
YUEYANG INTEGRATED TRADITIONAL CHINESE & WESTERN MEDICINE HOSPITAL SHANGHAI UNIV OF CHINESE TRADITIONAL MEDICINE
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0004] Traditional Chinese medicine has rich experience in the treatment of atopic dermatitis. It adopts methods such as expelling wind and dampness, clearing away heat and detoxification, nourishing blood and promoting blood circulation, nourishing yin and tonifying kidney, etc. It has achieved considerable clinical curative effect and has a high reputation among patients. However, due to the limitations of many conditions, including pharmaceutical preparations, drug stability, and objective evaluation of clinical efficacy, there is a lack of traditional Chinese medicine preparations for the treatment of atopic dermatitis.
At present, traditional Chinese medicine preparations are mainly used for the clinical treatment of skin pruritus, such as Wushe Zhiyang Pills and Fuyang Granules to treat atopic dermatitis, but the clinical efficacy is not significant
In view of the above situation, Chinese herbal medicines are mainly used to treat atopic dermatitis clinically, which brings great inconvenience to the patients. The development of safe and effective Chinese patent medicines for the treatment of atopic dermatitis will help the disease. The treatment and prevention play an active role in promoting the

Method used

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  • Traditional Chinese medicine granules for treating skin diseases related to blood-heat-yang floating syndrome and preparation thereof
  • Traditional Chinese medicine granules for treating skin diseases related to blood-heat-yang floating syndrome and preparation thereof
  • Traditional Chinese medicine granules for treating skin diseases related to blood-heat-yang floating syndrome and preparation thereof

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0039] The preparation of embodiment 1 granule

[0040] Preparation:

[0041] 1. Take the crude drug by weighing the formula in Table 1,

[0042] 2. Extraction:

[0043] The water extraction process is to add about 10 times the amount of water to Cortex Moutan or Xu Changqing, soak for 1 to 3 hours, distill, collect an appropriate amount of distillate, add 7% sodium chloride, salt out for 24 hours (low temperature), and suction filter to obtain Cortex Moutan Phenol crystallization, medicine dregs for use. Add about 10 times the amount of water to oysters, mother-of-pearl, and magnets, fry for 10-30 minutes, then add about 10 times the amount of boiling water, soak for 60 minutes, and add scutellaria baicalensis, comfrey, windproof, licorice, coix seed, vermicelli and the above peonies Peel or Xu Changqing herbal dregs, decocted together twice, each decocting 60min. The extract is concentrated to a relative density of 1.08 (70°C), added with 95% ethanol until the alcohol co...

Embodiment 2

[0049] The optimization of embodiment 2 preparation technology

[0050] Adopt formula 4 among the embodiment 1 to carry out research:

[0051] 1. Drying process research

[0052] 1.1 Determination of spray drying parameters

[0053] 1.1.1 Test operation

[0054] Weigh the prescription amount of crude drug, extract according to the extraction conditions in Example 1 to obtain the filtrate, concentrate the filtrate to a relative density of 1.05 (70°C), add 95% ethanol until the alcohol content reaches 70%, let stand overnight, suction filter, and concentrate .

[0055] 1.1.2 Relative density screening

[0056] Select the decocted medicinal liquid, adjust the concentration to relative density 1.08, 1.12, 1.15 (70°C) respectively, each medicinal liquid is equivalent to 4 plasters of traditional Chinese medicine, and each plaster adds 20% dextrin and 10% lactose was spray dried. The powder yield and water content are used as indicators to screen the relative density. The res...

Embodiment 3

[0140] Embodiment 3 pharmacodynamic research

[0141] experiment method:

[0142] Ear swelling test:

[0143] Method: The mice were randomly divided into 6 groups, 12 in each group, and administered continuously for 5 days. One hour after the last administration, 50ul of xylene was applied to the front and back sides of the right ear of the mice, and the mice were cut off after 20 minutes of application of xylene. The neck was put to death, and the two ears were cut off along the auricle line, and round ears were punched at the same position with a 6mm diameter punch, and weighed with an electronic balance. Swelling inhibition rate, comparing the significant difference between groups. A blank control group was set up, and Fuyang Granules (produced by Sichuan Yada Pharmaceutical Co., Ltd.) were used as a positive control.

[0144] Antipruritic test:

[0145] Method: The guinea pigs were randomly divided into 6 groups, 10 in each group, administered for 5 consecutive days, a...

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Abstract

The invention discloses Chinese medicinal granules for treating related skin disease such as blood heat yang floating disease and a preparation method thereof. The Chinese medicinal granules disclosed by the invention are obtained by extracting active ingredients from bulk drugs, preparing an extract, mixing the extract with auxiliary materials, carrying out spray drying and carrying out dry granulation. The bulk drugs comprise scutellaria baicalensis, nacre mother of pearl, lithospermum, magnetite, divaricate saposhnikovia root, raw licorice, raw semen coicis, raw oyster and tree peony bark or paniculate swallowwort root. Clinical experiment and animal drug effect and toxicology research result show that the Chinese medicinal granules disclosed by the invention have obvious effects of relieving itching and resisting to inflammation, is safe, produce no obvious side or toxic effect and have high clinical effectual rate.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicines and natural medicines, and in particular relates to traditional Chinese medicine granules for treating skin diseases related to blood-heat-yang floating syndrome and its preparation and application. Background technique [0002] Atopic dermatitis (AD, also known as atopic eczema) is one of the most challenging problems in modern dermatology. In recent years, the increasing incidence of AD has made it a prominent public health problem. Although AD can occur in all age groups, the prevalence of AD has increased by 2-3 times in the past 30 years. According to statistics, about 5-20% of children in the world suffer from the disease at present. Epidemiological evidence points to trends in urbanization, as well as Western lifestyles, as factors associated with increased prevalence of AD in recent decades. According to data published in Europe in 1990, it is estimated that the pr...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/8994A61K9/16A61P17/00A61K33/26A61K35/56A61K35/618
Inventor 李斌张宁奚燕范斌金若敏刘新华李福伦周婉徐玲玲王一飞张明徐蓉
Owner YUEYANG INTEGRATED TRADITIONAL CHINESE & WESTERN MEDICINE HOSPITAL SHANGHAI UNIV OF CHINESE TRADITIONAL MEDICINE
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