Unlock instant, AI-driven research and patent intelligence for your innovation.

Deproteinised porcine blood extract oral paste and its preparation technology

A preparation process and protein-removing technology, which is applied in the field of pig blood protein-free extract and pig blood protein-free extract oral ointment, can solve problems such as not being able to be directly used in clinical applications of patients, unsatisfactory drug effects, and difficult storage conditions, etc., to achieve Improve the body's immunity, reduce ulcer congestion, and control the effect of ulcer area

Active Publication Date: 2012-01-11
沈阳衡天然生物科技有限公司
View PDF3 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Chinese patent, the patent number is ZL200510132478.0, and the patent name "calf serum deproteinized oral ointment and its preparation method" discloses calf serum deproteinized oral ointment, which provides a kind of medicine for treating the above diseases, but this technology The protein-free extract pharmaceutical preparation is made of calf blood. Due to the limitations of the mad cow disease detection method and the limitation of mad cow disease virus inactivation, the drug effect is not ideal. Due to the selection of excipients, the drug has a slow onset of action , long course of treatment, widely restricted in clinical application
[0004] Although the deproteinized pig blood extract has the effect of promoting the uptake of oxygen and glucose by cells, it cannot be directly used in clinical applications of patients, and the extract is an aqueous solution with difficult storage conditions. Once the power failure will directly affect its quality
And the existing porcine blood deproteinized extract is an injection preparation, and its injection is mainly for the treatment of cerebrovascular diseases, and there is no report on oral injury and ulcer treatment research

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] Preparation of porcine blood deproteinized extract powder:

[0023] According to the preparation method described in the patent No. ZL200510046289.1, the title of the invention is "The method of extracting active substances that stimulate cell respiration from pig blood": take the healthy pigs that have passed the inspection in the non-infected area, use aseptic blood collection, and remove Fibrin, get 10L of defibrinated blood, freeze-thaw repeatedly (-20℃~40℃) 2-4 times; homogenize in a colloid mill at 2-8℃ for 2 minutes, repeat 3 times; take the homogenate in After centrifuging at 4000 rpm for 20 minutes, discard the precipitate; take the supernatant, and use 100000D, 30000D, 10000, 6000D hollow fiber ultrafiltration columns to perform four-stage ultrafiltration in sequence to obtain 7.2L of filtrate; the final ultrafiltrate Put it into a decompression concentration tank, and use a jet vacuum pump to vacuumize at 55 ° C to carry out decompression concentration to a...

Embodiment 2

[0025] Preparation of porcine blood deproteinized extract oral ointment (Containing 0.1% of pig blood protein-free extract powder, equivalent to 2.5% of pig blood protein-free extract solution)

[0026] 1. Preparation of matrix

[0027] Take 750g of pectin, 275g of glycerin, 967.5g of simethicone, 2000g of white petrolatum, 1000g of liquid paraffin, and 2.5g of ethylparaben, stir and mix well, and sterilize under high pressure (67kPa) at 115°C for 30 minutes.

[0028] 2. Pork blood deproteinized extract oral paste

[0029] Take 5 g of pig blood deproteinized extract powder prepared by the method of Example 1 and mix it with the above-mentioned sterilized base to make 5000 g of oral paste, pack it with a filler, and pack it into a medium, each 5 g, to get 1000 pigs Blood protein extract oral ointment.

Embodiment 3

[0031] Preparation of porcine blood deproteinized extract oral ointment (Containing 0.15% of pig blood protein-free extract powder, equivalent to 3.75% of pig blood protein-free extract solution)

[0032] 1. Preparation of matrix

[0033] Take 800g of pectin, 325g of glycerin, 864.5g of simethicone, 1875g of white petrolatum, 1125g of liquid paraffin, and 3.25g of ethylparaben, stir and mix well, and sterilize under high pressure (75kPa) at 120°C for 25 minutes.

[0034] 2. Pork blood deproteinized extract oral paste

[0035] Get 7.5g of the pig blood deproteinized extract powder prepared by the method of Example 1 and mix it with the above-mentioned sterilized matrix to make 5000g of oral paste, pack it with a filler, and pack it into a medicinal polyethylene composite hose. Stick 5g, promptly get 1000 sticks of pig blood deproteinized extract oral ointment.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention relates to a deproteinised porcine blood extract, especially to a deproteinised porcine blood extract oral paste and its preparation technology, is a medicine for treating oral mucosa, gum and lip injury, inflammation or ulcer, artificial denture pressure sore and the like, and belongs to the technical field of biological pharmacy. The deproteinised porcine blood extract oral paste is made from the following raw materials of: by weight, 0.1-0.3 part of a deproteinised porcine blood extract powder, 15-20 parts of pectin, 5.5-10.5 parts of glycerin, 9.1-19.3 parts of dimethicone, 30-40 parts of white vaseline, 20-30 parts of liquid paraffin and 0.05-0.1 part of methyl nipagin ester. The medicine provided by the invention is used to treat oral mucosa, gum and lip injury, inflammation or ulcer, artificial denture pressure sore and the like, can replace a similar biological product with bovine blood as a source, has high drug safety, and has a more obvious curative effect than a deproteinized calf blood oral paste.

Description

technical field [0001] The invention relates to a pig blood protein-free extract, in particular to a porcine blood protein-free extract oral ointment and a preparation process of the pig blood protein-free extract oral ointment. It is a new dosage form of pig blood protein-free extract. The pig blood protein-free extract oral ointment of the present invention is a medicine for treating oral mucosa, gum and lip damage, inflammation or ulcers, denture tray pressure sores, etc., and belongs to biological field of pharmaceutical technology. Background technique [0002] Oral ulcers are mostly seen in the mucous membranes of the lips, cheeks, soft palate, or gums of the oral cavity. Single or multiple round or oval ulcers of various sizes occur, the surface is covered with gray or yellow pseudomembrane, the center is depressed, and the border is clear. The mucous membrane is red and slightly swollen, and local burning pain of the ulcer is obvious, which has the characteristics o...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): A61K35/14A61K9/06A61K47/44A61P1/02
Inventor 王光李莉万琳琳刘路徐丽颖
Owner 沈阳衡天然生物科技有限公司