Preparation of long-acting chitosan/apatite/rifampicin composite material by biomimetic mineralization method

A biomimetic mineralization and composite material technology, applied in medical science, prosthesis, etc., can solve the problems of unguaranteed drug efficacy and safety, short drug release time, etc., and achieve the effect of maintaining drug activity and increasing sustained release time.

Inactive Publication Date: 2012-01-25
HARBIN INST OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0004] In order to solve the problems that the existing chitosan/apatite composite material is used as the LDDS drug carrier, the drug release time is short when the drug is in the physical adsorption

Method used

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  • Preparation of long-acting chitosan/apatite/rifampicin composite material by biomimetic mineralization method
  • Preparation of long-acting chitosan/apatite/rifampicin composite material by biomimetic mineralization method
  • Preparation of long-acting chitosan/apatite/rifampicin composite material by biomimetic mineralization method

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specific Embodiment approach 1

[0009] Specific embodiment one: the chitosan / apatite / rifampicin composite material of long-acting drug release is prepared by the biomimetic mineralization method of the present embodiment and is carried out according to the following steps: Acetic acid solution is used as a solvent, and a chitosan solution with a mass percentage concentration of 2% to 5% is prepared; 2. The chitosan solution prepared in step 1 is evenly applied to the inner surface of the capsule mold, and then soaked in the coagulation solution for 2 hours ~24h, after taking off the mould, a capsule-shaped chitosan hydrogel film is obtained; three, the chitosan solution prepared in step 1 is injected into the capsule-shaped chitosan hydrogel film prepared in step 2, and then the capsule-shaped chitosan water The gel film is first soaked in the coagulation solution for 1min to 20min, then soaked in the alcohol aqueous solution for 1min to 20min, repeats the alternate soaking operation for 120min, and then wash...

specific Embodiment approach 2

[0010] Embodiment 2: This embodiment differs from Embodiment 1 in that the thickness of the capsular chitosan hydrogel film in step 2 is 0.2 mm to 0.6 mm. Others are the same as the first embodiment.

specific Embodiment approach 3

[0011] Specific embodiment three: the difference between this embodiment and specific embodiment one or two is that the coagulation liquid described in step two is ammonia water with a mass percentage concentration of 5% to 10%, and a mass percentage concentration of 3% to 10% NaOH aqueous solution or an aqueous solution of KOH with a mass percent concentration of 3% to 10%. Others are the same as those in Embodiment 1 or 2.

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Abstract

The invention relates to a method for preparing a chitosan composite material, and particularly relates to the preparation of a long-acting chitosan/apatite/rifampicin composite material by biomimetic mineralization method. The invention aims to solve the problem that the physical adsorption manner of the existing chitosan/apatite composite material has short drug release time and the chemical adsorption manner can not ensure the efficacy when the existing composite material is used as the carrier of a local drug release system. The preparation method comprises the following steps: selecting a mold to prepare a capsule-shaped chitosan hydrogel film, injecting chitosan solution into the film, solidifying, washing and repeating the above steps multiple times to obtain chitosan hydrogel in a shape of concentric layer; loading rifampicin; soaking in a calcium salt solution, phosphate anion solution and physiological solution; freeze-drying the rifampicin-loaded chitosan/apatite composite hydrogel in the shape of concentric layer; soaking in a chitosan solution; taking out and fumigating with ammonia gas; and drying to obtain the composite material. The chitosan/apatite/rifampicin composite material has an acting duration equal to or larger than 400 hours, and can be used for the carrier material of sustained-release drug for repairing bone defect and lesions thereof.

Description

technical field [0001] The invention relates to a preparation method of a drug-loaded chitosan / apatite composite material, in particular to a method for in-situ loading of the anti-tuberculosis drug rifampicin in the process of synthesizing the chitosan / apatite composite material under mild conditions , to achieve long-term drug release. Background technique [0002] Bone tuberculosis is a chronic disease caused by tuberculosis infection of bones and surrounding soft tissues. Due to the severe tissue damage and fibrous hyperplasia in the cavities of tuberculosis lesions, the drugs are not easy to penetrate into the lesions due to the influence of local blood vessel scarcity and caseous necrosis. Therefore, there is not only a long course of treatment (0.5 to 1 year) through oral administration, but also long-term medication will damage liver and kidney functions. The cavity in the lesion is difficult to reach the effective drug concentration, which is the main reason for t...

Claims

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Application Information

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IPC IPC(8): A61L27/40A61L27/54
Inventor 李保强高永胜贾德昌周玉
Owner HARBIN INST OF TECH
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