Porous magnesium alloy/biological ceramic bionic composite support and quick forming method thereof

A technology of bioceramics and composite scaffolds, applied in bone implants, medical science, prostheses, etc., can solve problems such as the mismatch between the strength degradation rate and the bone reconstruction process, insufficient mechanical strength and stability, etc., to achieve the solution of mechanical strength Insufficient stability and reduced contact area

Active Publication Date: 2013-08-14
XI AN JIAOTONG UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The purpose of the present invention is to provide a rapid prototyping method for a porous magnesium alloy / bioceramic biomimetic composite scaffold to solve the problems of insufficient mechanical strength and stability in the early stage of bone scaffold implantation, and the mismatch between the strength degradation rate and the bone reconstruction process.

Method used

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  • Porous magnesium alloy/biological ceramic bionic composite support and quick forming method thereof
  • Porous magnesium alloy/biological ceramic bionic composite support and quick forming method thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0023] 1) First, according to the specific conditions of the patient's bone defect site, the shape correlation and microstructure bionic design of the bone defect site are carried out by means of reverse engineering and CAD technology, and the force, internal deformation and hydrodynamic properties of the stent are analyzed by CAE analysis software. The structure is modified to form a CAD model of the biomimetic scaffold with the internal microstructure of the primary and secondary two-stage pipelines that are not connected to each other;

[0024] 2) Mix deionized water, glycerin, organic monomer acrylamide, and crosslinking agent N,N-dimethylenebisacrylamide into a premix, wherein the quality of glycerin accounts for 20% of the total mass of the premix, and the organic monomer The mass ratio of crosslinking agent and monomer is 1:8, the balance is deionized water, and then the ceramic powder Beta-tricalcium phosphate (β-TCP) and dispersant polymer are added to the premix in ba...

Embodiment 2

[0028] Example 2: In this example, the bioceramic slurry was prepared by the following method, and other steps were the same as those in Example 1:

[0029] Mix deionized water, glycerin, organic monomer methyl-acyloxyethyl trimethyl ammonium chloride, and cross-linking agent N,N-diacetone acrylamide into a premix, wherein the mass of glycerol accounts for the total mass of the premix The mass ratio of crosslinking agent and monomer is 1:8, the balance is deionized water, and then the ceramic powder Alpha-tricalcium phosphate (α -TCP) and dispersant ammonium polyacrylate are prepared into ceramic slurry, wherein the volume ratio of ceramic powder to premix is ​​1:1, and the content of dispersant is 0.3% of the mass of ceramic powder, and then poured into a ball mill jar in a ball mill The ball mill was carried out for 2 hours, and the photoinitiator sodium persulfate with a mass of 1% of the mass of the premix solution was added, and the bioceramic slurry was obtained by furth...

Embodiment 3

[0030] Example 3: In this example, the bioceramic slurry was prepared by the following method, and other steps were the same as those in Example 1:

[0031] 2) Mix deionized water, glycerol, organic monomer adipic acid dihydrazide, and crosslinking agent dibenzylidene acetonyl acrylamide into a premix, wherein the quality of glycerol accounts for 20% of the total mass of the premix, and the organic monomer The mass of the body accounts for 26%, the mass ratio of crosslinking agent and monomer is 1:8, and the balance is deionized water. Then, ceramic powder apatite and dispersant sodium polyacrylate are added to the premix in batches to prepare ceramic slurry. The volume ratio of the ceramic powder to the volume of the premix is ​​1:1, the dispersant content is 0.3% of the mass of the ceramic powder, and then poured into a ball mill tank and ball-milled on a ball mill for 2 hours, and then added with a mass of 1% of the mass of the premix The photoinitiator potassium persulfate...

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Abstract

The invention relates to a porous magnesium alloy / biological ceramic bionic composite support and a quick forming method thereof. The quick forming method comprises the following steps of: performing appearance relativity, microstructural bionic design and structural optimization by means of reverse engineering and a computer-aided design (CAD) technology on the basis of analytical results of structures and biomechanics of different bone coloboma parts to establish a CAD model of the support; manufacturing a porous bioactive ceramic frame with two stages of pipelines which are not communicated mutually by a method for forming ceramics directly by photocuring; and casting molten magnesium alloy into a secondary pipeline of the biological ceramic frame by a vacuum suction casting method, cooling and solidifying to obtain the porous magnesium alloy / biological ceramic bionic composite support, wherein a primary pipeline is used for meeting the requirements of tissue growth and nutritionalmetabolism, and the magnesium alloy is filled into the secondary pipeline to enhance the mechanical property of the composite support and reduce a contact area of the magnesium alloy and body fluid, so that mass exchange of the magnesium alloy and a human body environment is avoided within a period of time of degrading ceramics to ensure the filled magnesium alloy provides continuous mechanical strength in the process of bone healing.

Description

technical field [0001] The invention belongs to the field of manufacturing engineering, and particularly relates to a rapid prototyping method for a porous magnesium alloy / bioceramic biomimetic composite stent. Background technique [0002] Large-scale bone defects caused by trauma, tumors, congenital deformities and other factors are clinical problems. According to statistics, more than 2.2 million bone defect repair operations are performed every year around the world. There are more than 15 million people with involuntary limbs in the country, of which 3 million are amputated due to lack of reconstructive surgery and bone replacement materials. The total market value of individual matching bones in my country is at least 50 million yuan each year. Bone tissue engineering provides a new idea for the permanent repair of bone defects. The construction of bone tissue engineering scaffolds with excellent comprehensive properties is the key to the final repair of bone defects...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L27/42A61L27/50A61F2/28B22D19/00
Inventor 连芩闫元媛李涤尘靳忠民刘亚雄贺健康李常海
Owner XI AN JIAOTONG UNIV
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