Veterinary antiviral and antifebrile drug composition

An anti-virus and composition technology, applied in the field of traditional Chinese veterinary medicine, can solve the problems of reducing the economic benefits of breeding, lack of anti-viral chemical drugs, and heavy workload, and achieve good antipyretic effect, good control effect, and less toxic and side effects

Active Publication Date: 2012-03-21
BEIJING DABEINONG ANIMAL HEALTH TECH +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] At present, there are many human chemical drugs and traditional Chinese medicines for the treatment of viral infections, but due to the constraints of biological safety, drug residues and cost, there are almost no antiviral chemical drugs approved for veterinary use, although there are many antiviral Chinese veterinary drug preparations , but not many have exact and significant clinical effects
Although there are antipyretic and analgesic chemical drugs such as metamizole, acetaminophen, aminopyrine, antipyrine and flunixin meglumine for the high fever symptoms caused by livestock and poultry virus infection, these drugs can only relieve Fever, no antiviral effect, cures the symptoms but not the root cause, after the symptoms are temporarily controlled, often rebound, although the mortality rate can be reduced to a certain extent, but the production performance of the surviving livestock and poultry is often greatly affected, thus greatly reducing the economic benefits of breeding
At present, combined medication is often used in clinical practice to prevent and treat high-grade fever and critical illness caused by various livestock and poultry viral infections, which not only requires heavy workload, great stress, high cost, but also unsatisfactory results.

Method used

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  • Veterinary antiviral and antifebrile drug composition
  • Veterinary antiviral and antifebrile drug composition
  • Veterinary antiviral and antifebrile drug composition

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] The drug in this example is prepared from the following raw materials: 4000g of Bupleurum radix, 3000g of cassia twig, 5000g of Radix isatidis, 4000g of Pueraria lobata, 3000g of honeysuckle, and 3000g of Analgin.

[0032] The preparation process is as follows: 1) Bupleurum bupleuri, cassia twig and honeysuckle are crushed separately, mixed, placed in a volatile oil extractor, soaked in water for 2 hours, and the amount of water added is more than 4 times of the total amount of medicinal materials. Boil and reflux for more than 6 hours, extract volatile oil, and set aside; 2) add Radix Radix to the mixture of medicinal residues and medicinal liquid after extracting volatile oil in 1), add water and decoct 3 times, and the amount of decoction added each time is more than 4 times the total weight of medicinal materials . Combine the decoctions, concentrate to 0.5 times the total weight of the medicinal materials, add ethanol to make the alcohol content reach 60%, let it s...

Embodiment 2

[0034] The drug in this example is prepared from the following raw materials: 1000g of Bupleurum radix, 1000g of cassia twig, 1000g of Radix isatidis, 1000g of Pueraria root, 1000g of honeysuckle, and 1000g of Analgin.

[0035] Prepare the oral liquid according to the method for preparing the injection in Example 1.

Embodiment 3

[0037] The medicine in this example is prepared from the following raw materials: Bupleurum bupleuri 8000g, cassia twig 6000g, isatidis 12000g, kudzu root 8000g, honeysuckle 6000g, analgin 5000g.

[0038] The preparation process is as follows: 1) Bupleurum bupleuri, cassia twig and honeysuckle are crushed respectively, mixed, placed in a volatile oil extractor, soaked in water for 2 hours, and the amount of water added is more than 4 times the total weight of the medicinal materials. Boil and reflux for more than 6 hours, fully extract the volatile oil, add the auxiliary material β-cyclodextrin to the volatile oil to prepare a cyclodextrin inclusion compound, and set aside; Decocting twice, the amount of water added each time is more than 4 times the total weight of the medicinal materials. Combine the decoction liquid, concentrate to 0.5 times of the total weight of the original medicinal materials, add ethanol to make the alcohol content reach 60%, let it stand for precipitati...

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Abstract

The invention relates to a veterinary antiviral and antifebrile drug composition and belongs to the field of traditional Chinese veterinary medicine. The drug composition provided by the invention comprises the components including Bupleurum, cassia twig, radix isatidis, kudzu, honeysuckle and analgin. The composition is Chinese and western compound, has a synergistic effect, and is used for preventing and treating hyperpyrexia caused by viral infection of livestock and poultry; the antiviral and the antifebrile effects are better than those of prescribed preparations of chemical drug and TCM (Traditional Chinese Medicine) preparations; and the drug composition has a very good effect on preventing and treating infection of various virus such as porcine circovirus type II, swine influenza virus, Newcastle Disease Virus (NDV) and the like, and has the advantages of less toxic side effects and low cost of drug material.

Description

technical field [0001] The invention relates to a veterinary antiviral and antipyretic pharmaceutical composition composed of Chinese and western medicines, belonging to the field of traditional Chinese veterinary medicine. Background technique [0002] Viral diseases of livestock and poultry are the most difficult diseases to prevent and control in the breeding industry. Many viruses can spread through the air, spread quickly, and have a wide range of epidemics. They often occur in groups, and the onset is acute. Decreased body immunity, often secondary to bacterial, mycoplasma and parasitic infections, high mortality. Due to the rapid mutation of the virus, the effect of vaccine immunization is often not ideal. Common livestock and poultry viral diseases such as: porcine circovirus disease, blue ear disease, swine fever, swine flu, porcine pseudorabies, chicken Newcastle disease, chicken infectious bursal disease, avian influenza, etc. These diseases are prevalent all ov...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/54A61K9/00A61K9/16A61K9/14A61P31/12A61P31/16A61P31/14A61P31/20A61K31/4152
Inventor 邓利斌莫云刘澜贠桂玲杜继红王海良
Owner BEIJING DABEINONG ANIMAL HEALTH TECH
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