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Erigeron breviscapus extract and preparation method and application thereof

A technology of Erigeron breviscapus and extract, which is applied in the field of medicine, can solve the problems of large loss, influence on drug efficacy, loss of active ingredients, etc., and achieve the effects of quality control, disease control, and simple production and operation

Active Publication Date: 2013-12-11
YUNNAN PHYTOPHARML
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

After adding ethanol to a certain concentration, the alcohol-insoluble components are removed by static precipitation to achieve the purpose of clarification. During the alcohol precipitation process, the active substances are easily wrapped by micelles, resulting in serious loss of active ingredients, which affects the efficacy of the drug. At the same time, it requires consumption with a lot of alcohol
There are also conventional methods such as using activated carbon or diatomaceous earth for decolorization and filtration. Although activated carbon or diatomite can clearly clarify the extract, its adsorption has a relatively large impact on the loss of active ingredients scutellarin and caffeic acid substances. Big
There are other methods of extraction using n-butanol. n-butanol is a volatile, flammable and explosive liquid, which has certain pollution and danger to the production environment and is also toxic to the human body.

Method used

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  • Erigeron breviscapus extract and preparation method and application thereof
  • Erigeron breviscapus extract and preparation method and application thereof
  • Erigeron breviscapus extract and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0081] The preparation method of breviscapine extract is as follows:

[0082] Take the dried whole herb of Compositae Erigeron scutellaria, add 70% ethanol solution according to 8 times, 6 times, 6 times the amount of medicinal materials, reflux extraction 3 times, 1.5 hours each time, combine the extracts, concentrate, adjust the pH to 6.5 , add 1 times the amount of 1.5% protein dry solution to the concentrated solution, stir and mix evenly, then heat to boil, let it stand and cool to room temperature, after cooling, the medicinal solution is refrigerated for more than 24 hours, filtered, and concentrated to a relative density of 1.0-1.35 (g / ml ) liquid extract or concentrated and dried into extract powder.

[0083] The breviscapine extract prepared by the above method contains 1-40% by weight of total flavonoids, 0.1-5% of scutellarin, 0.05-3% of chlorogenic acid, 0.002-3% of caffeic acid, 1,3- O - 0.01-3% of dicaffeoylquinic acid, 2-98% of other ingredients, the extract i...

Embodiment 2

[0085] The relative density prepared according to Example 1 is 400 g of the extract of Erigeron breviscapus extract of 1.02, adding 450 mg of 60% sucrose solution, 2 g of sodium benzoate, 0.2 g of ethylparaben, 0.6 g of stevia and distilled water to mix, Add water to 900ml, adjust the pH to 7.3 with 10% NaOH solution, set the volume to 1000ml, filter, fill, sterilize, fill 10ml per bottle, and obtain oral liquid.

Embodiment 3

[0087]According to Example 1, prepare 200 g of Erigeron breviscapus extract with a relative density of 1.02, add 120 g of sorbitol, 2 g of sodium benzoate, 0.2 g of ethylparaben, 0.4 g of aspartame, and distilled water to mix, add water to 900 ml , adjust the pH to 7.3 with 10% NaOH solution, set the volume to 1000ml, filter, fill, sterilize, and fill 10ml of each tube to obtain the oral liquid.

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Abstract

The invention relates to an erigeron breviscapus extract and a preparation method and an application thereof. The erigeron breviscapus extract contains ingredients according to the following percentages by weight: 1-40% of total flavonoids, 0.1-5% of scutellarin, 0.05-3% of chlorogenic acid, 0.002-3% of caffeic acid, 0.01-3% of 1,3-O-dicaffeoylquinic acid, and 2-98% of other ingredients, and is liquid extract or powdered extract with relative density of 1.0-1.35g / ml. The invention is simple in production operation, clean and pollution-free, lower in cost, economical and practical, environmentally-friendly and safe compared with a traditional production technology; the erigeron breviscapus extract contains few impurities, the contents of known effective components such as the scutellarin, the chlorogenic acid, the caffeic acid and the 1,3-O-dicaffeoylquinic acid which play a leading role in the treatment of cardio-cerebrovascular diseases are all higher than the contents in the traditional technology, the range is clear and definite, and the quality is controllable; and the erigeron breviscapus extract in a dosage form convenient for taking is fast in absorption, high in bioavailability, convenient to carry, and especially suitable for being taken by the aged, apoplexy patients and patients difficult to swallow, and can quickly take effect and effectively control the state of diseases when the patients take the erigeron breviscapus extract in acute attack stages of coronary disease, angina pectoris and the like.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to an extract of Erigeron breviscapus and its preparation method and its application in the preparation of cardiovascular and cerebrovascular disease prevention and treatment drugs and health care products. Background technique [0002] Cardiovascular and cerebrovascular diseases are the "No. 1 killer" that seriously affects human health. It ranks first in the cause of death in my country, and the incidence rate is increasing year by year. At present, 160 million people in my country suffer from cardiovascular and cerebrovascular diseases such as hypertension and arteriosclerosis; about 57% of people over the age of 40 suffer from various degrees of cardiovascular and cerebrovascular diseases. Nearly half of the urban deaths are due to cardiovascular and cerebrovascular diseases. The sales volume of cardiovascular and cerebrovascular drugs in my country ranks third in the ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/352A61K31/216
Inventor 郭文梅艳李俊
Owner YUNNAN PHYTOPHARML