Double-cavity bag packed cefpirome sulfate injection and preparation method thereof

Abstract

The invention discloses double-cavity bag packed cefpirome sulfate injection. The injection medicinal composition consists of the following Chinese herbal medicines: 0.5 to 2 weight parts of cefpirome sulfate (based on cefpirome) in a powder cavity, and 100 volume parts of glucose injection with 4 to 11 weight parts of glucose or 100 volume parts of sodium chloride injection with 0.8 to 1 weight part of sodium chloride in a liquid cavity. The cefpirome sulfate injection is packed in a double-cavity bag, and cefpirome sulfate sterile medicine powder and a solvent (the sodium chloride injection or the glucose injection) are filled in the two cavities separated by cold joint; and a cold joint isolating bar can be opened only by extruding the medicine bag during use, so that the cefpirome sulfate sterile medicine powder and the solvent can be quickly dissolved and mixed under the closed sterile condition, and full medicine treatment mixed liquid is formed and is directly applied to a patient.

Description

technical field [0001] The invention relates to a pharmaceutical composition and a preparation method thereof, in particular to a double-cavity bag-packed cefpirome sulfate injection and a preparation method thereof. Background technique [0002] Cefpirome sulfate chemical name: (6R,7R)-7-[(Z)-2-(2-amino-4-thiazolyl)-2-methoxyiminoacetamido]-3-(6,7- Dihydro-5H-cyclopent[b]pyridin-1-ylmethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxymonosulfuric acid Salt is a fourth-generation cephalosporin antibiotic. It works mainly by blocking the synthesis of peptidoglycan, the main cell wall polymer. Because it can quickly penetrate the cell wall of bacteria and bind with high affinity to the target enzyme (penicillin-binding protein), it can have a bactericidal effect on a wide spectrum of Gram-negative and Gram-positive pathogenic bacteria at a low concentration level. It is used for the treatment of sepsis, lower respiratory tract infection, abdominal cavity and biliary ...

AI Technical Summary

Problems solved by technology

[0003] At present, the main preparation forms of this product at home and abroad are: freeze-dried powder injection, aseptic subpackage powder injection, small-volume injection, etc., and the above-mentioned preparations must use appropriate solvents (such as 0.9% chlorine dioxide) before infusion into the patient's body. Sodium chloride injection or 5% glucose injection) can be dissolved or diluted into a solution with a concentration lower than 2mg / ml before intravenous infusion, and the process of dissolving and diluting is relatively time-consuming. Due to the cumbersome dispensing process, rapid intravenous administration is often not possible under certain conditions; the site area of ​​ambulance equipment is narrow and the movement is bumpy, making it difficult to perform dispensing operations or medical errors or accidents such as dispensing errors; air and particle pollution in the ambulance site can easily cause secondary accidents. secondary pollution; therapeutic drugs are packaged in glass bottles, which are easily broken and cannot be airdropped; there are problems such as the matching of therapeutic drugs and carrier infusion quantities and expiration dates in war storage, resulting in the environment and time of the rescue site not reaching the standard for conventional infusion preparation. needs

[0004] Freeze-dried powder injections and sterile subpackaged powder injections sold in the market are all packaged in vials and sealed with butyl rubber stoppers. During the storage and transportation of drugs, when the drug powder comes into contact with the rubber stoppers, the additives in the rubber stoppers may be precipitated or A physical or chemical reaction with the drug powder will lead to unqualified test results of solution clarity and affect the safety of product use

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