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Method for preparing benzbromarone tablets

A technology of benzbromarone tablets and benzbromarone, which is applied in the field of preparation of benzbromarone tablets, can solve problems such as easy generation of static electricity, influence on product quality, and inconspicuous improvement of tablet dissolution, so as to achieve guaranteed efficacy, The effect of improving bioavailability

Active Publication Date: 2012-05-02
常州康普药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The disadvantage is that the benzbromarone raw material is crushed, and after the particle size is reduced, it is easy to generate static electricity, so it is easy to form agglomerates due to static electricity in the subsequent granulation, which affects product quality
And because the particle size of the raw material is still relatively large due to the traditional pulverization method, the improvement of the dissolution of the tablet is not obvious

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] Prepared per 10,000 pieces

[0020] (1) The raw material benzbromarone is ultrafinely pulverized by a jet mill until the particle size D50 is less than 5 μm; other raw and auxiliary materials such as magnesium stearate, microcrystalline cellulose, hydroxypropyl cellulose and lactose are pulverized by a universal high-speed pulverizer , after pulverization, sieve through a 120-mesh sieve with a vortex vibrating sieve; weigh the sieved raw and auxiliary materials, and take 500 g of the raw and auxiliary materials benzbromarone; take 20 g of magnesium stearate, 200 g of microcrystalline cellulose, 750 g of lactose, hydroxypropyl Cellulose 570g is spare.

[0021] (2) Prepare adhesive: (every ten thousand pieces): 400ml of 1-3% hydroxypropyl methylcellulose 30% ethanol solution, add 25ml polysorbate-80, add 10g sodium lauryl sulfate as binding agent;

[0022] (3) 500 g of benzbromarone is transferred to the fluidized bed, and the fan frequency is set so that the material i...

Embodiment 2

[0028] Prepared per 10,000 pieces

[0029] (1) The raw material benzbromarone is ultrafinely pulverized by a jet mill until the particle size D50 is less than 5 μm; other raw and auxiliary materials such as magnesium stearate, microcrystalline cellulose, hydroxypropyl cellulose and lactose are pulverized by a universal high-speed pulverizer , after pulverization, use a vortex vibrating sieve to pass through a 120-mesh sieve; weigh the sieved raw and auxiliary materials, take 500 g of the raw and auxiliary materials benzbromarone, and use a jet mill to carry out ultrafine pulverization until the particle size is less than 5 μm; take stearic acid Magnesium 20g, microcrystalline cellulose 166.6g, lactose 625.05g, hydroxypropyl cellulose 528.35g, spare;

[0030] (2) Prepare adhesive: (every ten thousand pieces): 800ml of 1-3% hydroxypropyl methylcellulose 30% ethanol solution, add 45ml polysorbate-80, add 30g sodium lauryl sulfate as binding agent;

[0031] (3) 500 g of benzbrom...

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Abstract

The invention discloses a method for preparing benzbromarone tablets. By the method, the dissolution of the benzbromarone tablets can be obviously improved. The method comprises the following steps of: treating a benzbromarone raw material by a jet milling method until the particle size D50 is 5mu m; combining part of dodecyl sodium sulfate and Tween-80 in a prescription with the micronized raw material through a fluidized bed; and pelletizing and tabletting the obtained material and other auxiliary materials. The dissolution of the prepared tablets is obviously improved.

Description

technical field [0001] The invention relates to a preparation method capable of significantly improving the tablet dissolution rate of insoluble drug benzbromarone. Background technique [0002] Benzbromarone Tablets is a drug for the treatment of simple primary hyperuricemia and non-attack gouty arthritis. Gout is a disease in which purine metabolism disorder and uric acid excretion decrease, and blood uric acid increase causes tissue damage. Its clinical features are hyperuricemia and recurrent attacks of characteristic acute arthritis. In the past, gout was a common disease in European and American countries, but it was relatively rare in Eastern countries. However, in my country, with the improvement of people's living standards in recent years, the number of gout patients is also increasing, and the demand for clinical anti-gout drugs is also increasing day by day. [0003] For the existing drugs such as colchicine, non-steroidal anti-inflammatory drugs, probenecid, ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/20A61K31/343A61P19/06
Inventor 王苏南汤金春
Owner 常州康普药业有限公司
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