Method for preparing degradable polymer sacculus

Abstract

The invention relates to a method for preparing a degradable polymer sacculus. The method comprises the following concrete steps of: dissolving a biodegradable polymer into an organic solvent for being prepared to be 1-30 percent by mass; adopting an electrostatic spinning method and controlling the spray rate to 0.1-2.0mL/h and the voltage to 3,000-30,000V, wherein the distance between a spray opening of an ejector and a receiving device is 1-20mm, and the rotating speed of the receiving device is 1-100rpm; and collecting a sprayed filament to obtain a degradable polymer sacculus. The sacculus is a biodegradable macromolecule sacculus with favorable mechanical performance, large degradable and mechanical strength and favorable flexibility. The prepared sacculus can bear 6-12 atmospheric pressures and ensure that the compressed centrum height is increased and even completely restored. The degradation mass of the degradable polymer sacculus in two weeks in serum is 10-20 percent (w/w). The method solves the problems of bone cement collapse, leakage and the like, not only overcomes the defects of PVP (Polyvinyl Pyrrolidone) and PKP (Penetrating Keratoplasty) but also expands the application range of operation. The method disclosed by the invention has simple preparation process.

Description

technical field [0001] The invention relates to a preparation method of a degradable polymer balloon. Background technique [0002] Trauma, disease (such as systemic disease, tumor, etc.) and osteoporosis can all cause vertebral fractures. Severe pain and limited activity caused by vertebral fractures reduce the patient's quality of life, and may cause other lesions, even lead to paraplegia and death. Clinically, certain vertebral body lesions (such as osteoporosis, tumors, etc.) and trauma often lead to vertebral body compression fractures, vertebral body collapse, etc., which induce intractable pain and angular deformity, and increase the damage and degeneration of other parts. The probability of changing, even causing paraplegia, is extremely harmful to the patient's body and mind. The ideal treatment should provide rapid relief of pain from the fracture and correction of the kyphosis caused by the fracture. Percutaneous kyphoplasty (PKP) is to insert a puncture cannul...

AI Technical Summary

Problems solved by technology

[0003] In recent years, some studies have used a capsule bag instead of a bone expander, and injected bone cement directly after implanting the vertebral body, which can reduce the overflow of bone cement. However, due to the large pores of the capsule bag, calcium phosphate bone cement cannot be used. and complications remain uncorrected

There are also studies using polymer film materials, such as silica gel films, to make balloon materials to prevent the collapse and leakage of bone cement before vertebroplasty, but due to the non-degradability of the material, the gap between bone and bone cement The presence of a septum affects the combination of bone cement and trabecular bone, increasing the instability of the fractured vertebral body

Some degradable polymer films, such as polylactic acid, are also used. Although they are degradable, the film-forming strength is insufficient, and they are easy to rupture under pressure, resulting in leakage of CPC, and their degradation speed is slow, which affects the repair performance of vertebral bones.

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