Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Application of hydrogen to preparation of medicament and health-care beverage for preventing kidney stones

A technology for health drinks and kidney stones, applied in the application field of medicines or health drinks, can solve the problems of being difficult to be used as a general clinical treatment method, failing to attract people's attention, and difficult to preserve active enzymes, and to increase urinary citrate. Effect of excretion, low cost, calcium oxalate crystal reduction

Inactive Publication Date: 2012-05-23
上海交通大学医学院附属第三人民医院
View PDF4 Cites 7 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] Patent WO2007 / 075447A2 discloses a granule containing oxalate-degrading enzymes, which can be used to treat and prevent idiopathic calcium oxalate kidney stones, and has achieved good results, but the active enzymes are difficult to preserve and the cost is too high, and The granules are only limited to the prevention of calcium oxalate stones, and have no effect on calcium phosphate stones, uric acid stones, magnesium ammonium phosphate stones or cystine stones
[0009] It has always been believed that hydrogen, like helium, is a physiologically inert gas that does not react with any substance in the human body. However, as early as 1975, someone published a paper in the journal "Science" proving that hydrogen can effectively treat malignant melanoma in animal skin. In 2001, French diving physicians confirmed that hydrogen can treat the inflammatory response caused by hepatic Schistosoma mansoni infection. Although the above research overturned the traditional view that hydrogen is an inert gas, it did not attract people's attention
Moreover, the research of hydrogen in the treatment of kidney stones has not yet been reported
In particular, there is a danger of explosion in the process of mixing high-pressure hydrogen with other gases, and it is difficult to use it as a general clinical treatment.

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Application of hydrogen to preparation of medicament and health-care beverage for preventing kidney stones
  • Application of hydrogen to preparation of medicament and health-care beverage for preventing kidney stones
  • Application of hydrogen to preparation of medicament and health-care beverage for preventing kidney stones

Examples

Experimental program
Comparison scheme
Effect test

Embodiment approach 1

[0027] Taking the reaction of water and metal magnesium to generate hydrogen as an example, the hydrogen is dissolved in water to make an oral liquid containing hydrogen, and the redox potential of the oral liquid is controlled to be -50mV, and the hydrogen concentration is 0.08ppm. Then use the prepared oral liquid to carry out animal experiments.

[0028] Select 24 healthy clean adult male Wistar rats weighing between 180g and 220g (purchased from Shanghai Slack Experimental Animal Co., Ltd.), and randomly divide them into ethylene glycol lure stone + oral liquid intervention group (group A), Simple ethylene glycol stone-attracting group (group B) and blank control group (group C). The three groups were adaptively fed for one week in the same environment, and then treated for 4 weeks according to the following methods: Group A was given 1% ethylene glycol solution as the only drinking water source, and at the same time was fed freshly prepared hydrogen-containing oral liquid...

Embodiment approach 2

[0045] Referring to Embodiment 1, hydrogen is dissolved into milk under pressure to produce hydrogen-containing milk, and the oxidation-reduction potential of the produced milk is controlled at ≤ -50mV.

Embodiment approach 3

[0047] Referring to Embodiment 1, hydrogen is dissolved into fruit juice under pressure to produce a hydrogen-containing fruit juice drink, and the oxidation-reduction potential of the produced fruit juice drink is controlled at ≤ -50mV.

[0048] While dissolving hydrogen into milk or fruit juice, flavoring agents can also be added to make beverages with various flavors, which can meet the taste preferences of people's daily drinking, and also have the effect of preventing kidney stones.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention provides an application of hydrogen to preparation of a medicament and a health-care beverage for preventing kidney stones. Hydrogen is prepared into an oral preparation or beverage; after the oral preparation or the beverage is taken, oxalic acid output can be effectively lowered, and urine citric acid concentration is increased; and meanwhile, SOD (Super Oxygen Dehydrogenises) activity can be increased, the generation of MDA (Methane Dicarboxylic Aldehyde) and formation of calcium oxalate stones are reduced, and the reoccurrence of calcium oxalate stones is prevented.

Description

technical field [0001] The invention relates to a new application of hydrogen, in particular to an application of hydrogen in the preparation of medicines or health drinks for preventing kidney stones. Background technique [0002] The kidney is part of the urinary system and is responsible for filtering impurities in the blood, excreting metabolic waste, poisons, and drugs, and maintaining the balance of body fluids and electrolytes. It also has endocrine functions to regulate blood pressure. Traditional Chinese medicine believes that the kidney, one of the five internal organs, stores essence , the main development growth and reproduction, is the congenital foundation and the root of life, is the human body and its important organs. [0003] Kidney stones are a common disease of the kidneys. With the increase in the intake of animal protein, salt and sugar, the incidence of kidney stones has also increased significantly; once the stones form, they will cause great damage t...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): A61K33/00A61K9/00A61P13/04A23L2/54A23L1/30A23C9/152A23F3/00A23F5/00
Inventor 张士青
Owner 上海交通大学医学院附属第三人民医院
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products