Adaptive optics technology based living human eye retinal cell microscope

Abstract

The invention discloses an adaptive optics technology based living human eye retinal cell microscope, which comprises an observation optical system, an illuminating optical system, an aberration correction micromechanical deformation mirror, a retinal cell image post-processing module, a deformation mirror correction control model and an image post-processing module, wherein the deformation mirror correction control model is used for proposing a wavefront correction arithmetic based on singular value decomposition and Smith control, and optimally the correction property of a system on spatialdomain and time domain, and the image post-processing module is used for carrying out iterative restoring according to a point spread function constructed by human eye residual aberration, a consistency measurement function of a resorting problem and a cost punishment function of prior information so as to obtain a target image, and thus, the observation and the diagnosis of doctors are convenient.

Description

Technical field: [0001] The invention belongs to the field of ophthalmic medical observation and diagnosis equipment, and is especially used for observing the retina of living human eyes and early diagnosis of diseases on the cell scale. Background technique: [0002] Retinal diseases are closely related to the state of retinal tissue, especially the distribution of retinal cells. By observing the tissue state of the retina at the cell level and accurately measuring the density of retinal cells, the type of retinal disease can be diagnosed, the treatment plan can be formulated, and even high blood pressure can be diagnosed. Provide means for ultra-early diagnosis of systemic diseases such as diabetes and diabetes. Therefore, it is of great significance to design the optical observation system of the retina living tissue microscope. [0003] The human eye is a complex optical system, especially the aberration of the human eye not only affects the observation of the external ...

AI Technical Summary

Problems solved by technology

[0005] 1. Human eye pupil automatic positioning and multi-field positioning: When the system is working, in order to ensure that the light beam can continuously and stably enter the fundus through the pupil, the human eye and the device should be able to maintain a relatively fixed position for a long time. A slight movement of the head will cause the pupil to deviate from the optical path of the system, causing the sensor to fail to obtain a complete spot image, affecting the accuracy of aberration measurement and the effect of aberration correction

Due to the small field of view of the system during cell imaging, which is about 1.2°, the imaging of retinal cells around the macula needs to be achieved by positioning targets in different directions, and if you look at the target for a long time, it will cause eye fatigue and miosis , will also affect the aberration measurement and correction accuracy

If the above problems cannot be solved well, it will increase the difficulty and accuracy of detection. Therefore, the success rate of generally ingesting retinal cells is relatively low, which cannot meet the needs of medical clinical use.

[0006] 2. Lack of the function of automatically compensating for refractive errors: the maximum deformation parameter of the mirror surface of the deformable mirror determines that the correction ability of the deformable mirror to the main aberration defocus and astigmatism of the human eye is very limited, and it will also affect the ability to correct higher-order aberrations Therefore, examiners with high myopia or astigmatism need to wear lenses to pre-correct myopia and astigmatism, but this is not convenient for clinical application

[0007] 3. The real-time control model of the deformable mirror in the system: the delay of the system seriously affects the correction effect of the system, the bandwidth of the control system must match the bandwidth of the human eye aberration, the dynamic change of the human eye aberration, and the control algorithm of the deformable mirror The errors caused will affect the speed and accuracy of the system

Although the above process can correct the wavefront distortion of the beam through adaptive optics technology, due to the influence of the system's own design, computer processing power, closed-loop correction bandwidth, wavefront reconstruction error, deformable mirror control response delay, and noise, adaptive optics will affect the human eye. The correction of aberration is not sufficient, there is still some residual aberration, and the high-frequency information of retinal cells is still severely suppressed and attenuated. Therefore, the initial retinal image obtained by the system must be post-processed based on digital technology in order to obtain high Clear Cell Image

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