Silk fibroin/calcium phosphate bone cement-based porous composite material and preparation method thereof

Abstract

The invention discloses a silk fibroin/calcium phosphate bone cement-based porous composite material and a preparation method thereof. The composite material comprises calcium phosphate, silk fibroin and calcium sulfate. The preparation method comprises the following steps of: adding silk fibroin grains with a hollow structure into composite powder of calcium phosphate and calcium sulfate to prepare a composite material solid phase; and adding a solidified liquid into the solid phase in a certain liquid-solid ratio, and blending into paste, wherein a final product is hydroxyapatite similar to the ingredient of human bone. The composite material can be directly injected into surgical sites by an injector, and can be accurately molded and solidified to form a bone repairing filling material; or the composite material can perform self-solidification at in vitro environment and then is implanted into the human body to be used as a bone repairing implanting material. According to the invention, a pore structure is formed by swelling and deformation of silk fibroin in the solidification process of calcium phosphate bone cement base, so that the composite material is good in toughness and biocompatibility, and the pore structure of calcium phosphate bone cement is improved, and the calcium phosphate bone cement is more close to an artificial bone. Thus the composite material disclosed by the invention has wide application prospect.

Description

technical field [0001] The invention relates to an artificial bone, in particular to a calcium sulfate-containing composite material with silk fibroin particles as a pore-forming agent and calcium phosphate bone cement as a matrix and a preparation method thereof, belonging to the technical field of biomedical materials. Background technique [0002] The traditional artificial bone needs to be prefabricated into a certain shape in vitro and then implanted into the human body for bone repair. This kind of operation is traumatic. Injectable artificial bone repairs bone defects with less trauma, and has obvious advantages in the repair of superficial, cystic and vertebral bone defects. It is attracting increasing attention and becoming the future development direction of artificial bones. Injectable artificial bone can be divided into two types: self-curing and non-self-curing. Commonly used injectable materials include injectable calcium sulfate, calcium phosphate and compoun...

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Problems solved by technology

Chinese invention patent (CN 1736492) discloses a silk fibroin hydroxyapatite composite material and its preparation method. Although the composite material obtained in this invention has good mechanical properties, it needs to be dried at a temperature of 110-130°C Curing, non-injectable, not self-curing, not solidifying in vivo and forming accurately, can only be used as implant material, which greatly affects the application of silk fibroin in bone defect repair

Xie Ruijuan et al. used silk fibroin to improve the mechanical properties of calcium phosphate bone cement and achieved good results, but the structure of this material is dense, which is not conducive to the growth of bone tissue and blood vessels, and the degradation rate is slow (see literature Preparation of CPC / SF composites. Journal of Textile Science, 2009, 30(10):5-9. Properties of silk fiber reinforced calcium phosphate bone cement, Polymer Materials and Scientific Engineering, 2011, 27(1):92-95. A silk fibroin / calcium phosphate bone cement composite material and its preparation method, CN 101961509A)

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