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Method for separating and purifying erythritol from mother liquid obtained after repeated crystallization of erythritol

A technology of erythritol and multiple crystallization, which is applied in the field of bioengineering, can solve the problems of no mention of erythritol mother liquor treatment method, short chromatographic resin life, and no economic value, so as to reduce membrane pollution load and reduce Concentration, the effect of reducing environmental pressure

Active Publication Date: 2012-07-25
FUTASTE PHARM CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

But above-mentioned two patent methods are all for fermented yeast liquid of erythritol, do not mention the processing method for the mother liquor of erythritol after multiple crystallization
[0005] Patent CN1932002 introduces a method for separating and purifying the mother liquor after multiple crystallizations by using calcium-type sulfonic acid-type ion exchange chromatography, but this requires continuous detection of the effluent components, and the operation is quite complicated
The price of chromatographic resin is as high as hundreds of thousands per ton. Due to the complex composition of the feed liquid and the relatively high concentration of impurities, the life of the chromatographic resin is very short, the extraction cost is high, and there is no economic value at all.

Method used

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  • Method for separating and purifying erythritol from mother liquid obtained after repeated crystallization of erythritol
  • Method for separating and purifying erythritol from mother liquid obtained after repeated crystallization of erythritol

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] 1. Pretreatment: Take the mother liquor after multiple crystallizations of erythritol and dilute it with pure water to obtain a 20% Brix dilution;

[0023] 2. Ultrafiltration treatment: Ultrafiltration treatment is performed on the diluted solution obtained above. The pressure before the membrane is 0.2mpa, the pressure behind the membrane is 0.18mpa, and the membrane flux is 300-400ml / min?㎡. The obtained permeate Brix was 19%, and the light transmittance was 9.7%.

[0024] 3. Nanofiltration treatment: Add the above-mentioned permeate into the feed barrel of multi-connected nanofiltration membranes with a molecular weight cut-off of 500D-800D. The working pressure is: 1.8mpa in front of the membrane, 1.75mpa behind the membrane, the flow rate of the dialysate is 150 ml / min?㎡, and the flow rate of the concentrate is 4.7L / min?㎡. The resulting dialysate had a Brix of 9.1%, a light transmittance of 84%, and an erythritol content of 76.8% as detected by HPLC.

[0025] 4....

Embodiment 2

[0031] 1. Pretreatment: Take the mother liquor after multiple crystallizations of erythritol and dilute it with pure water to obtain a 31% Brix dilution;

[0032] 2. Ultrafiltration treatment: Ultrafiltration treatment is performed on the diluted solution obtained above. The ultrafiltration membrane with a cut-off of 300,000 D is used, the pressure before the membrane is controlled to be 0.25mpa, the pressure behind the membrane is 0.23mpa, and the membrane flux is 250-300ml / min?㎡. The obtained permeate Brix was 24%, and the light transmittance was 7.7%.

[0033] 3. Nanofiltration treatment: Add the above-mentioned permeate into the feed barrel of multi-connected nanofiltration membranes with a molecular weight cut-off of 500D-800D. The working pressure is: 2.3mpa in front of the membrane, 1.5mpa behind the membrane, the flow rate of the dialysate is 120ml / min?㎡, and the flow rate of the concentrate is 4.6L / min?㎡. The obtained dialysate Brix is ​​10.2%, the transmittance is...

Embodiment 3

[0040] 1. Pretreatment: Take the mother liquor after multiple crystallizations of erythritol and dilute it with pure water to obtain a 39% dilution of Brix;

[0041] 2. Ultrafiltration treatment: Ultrafiltration treatment is performed on the diluted solution obtained above. The pressure before the membrane is 0.32mpa, the pressure behind the membrane is 0.3mpa, and the membrane flux is 150-220ml / min?㎡. The obtained permeate Brix was 26%, and the transmittance was 5.6%.

[0042] 3. Nanofiltration treatment: Add the above-mentioned permeate into the feed barrel of multi-connected nanofiltration membranes with a molecular weight cut-off of 500D-800D. The working pressure is: 1.8mpa in front of the membrane, 1.75mpa behind the membrane, the flow rate of the dialysate is 79ml / min?㎡, and the flow rate of the concentrate is 4.6L / min?㎡. The resulting dialysate had a Brix of 12.6%, a light transmittance of 72%, and an erythritol content of 88% as detected by HPLC.

[0043] 4. Activat...

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Abstract

The invention discloses a method for separating and purifying erythritol from mother liquid obtained after repeated crystallization of erythritol, relating to the field of bioengineering. The method provided by the invention comprises the following steps: diluting the mother liquid obtained after repeated crystallization of erythritol with pure water, removing impurities and purifying the mother liquid obtained after repeated crystallization of erythritol by adoption of ultrafiltration membrane and nanofiltration membrane technologies, and producing acceptable erythritol crystal product in one time in combination with activated carbon decolorization and ion exchange technologies. Specifically, the method comprises the steps of (1) pretreatment, (2) ultrafiltration treatment, (3) nanofiltration treatment, (4) activated carbon decolorization, (5) ion exchange, and (6) concentration and crystallization. The method provided by the invention is mild in process conditions and simple in operation, extracts high-quality erythritol from the waste mother liquid obtained after repeated crystallization of erythritol, effectively reduces the production cost, and relieves the stress of environmental protection.

Description

technical field [0001] The invention relates to the field of bioengineering, in particular to a method for separating and purifying erythritol crystals from mother liquor after multiple crystallizations of erythritol. Background technique [0002] Erythritol is a low-calorie tetraol with a sweetness of 60-80% of sucrose. Its chemical name is 1,2,3,4-butanetetraol, and its calories are only one-tenth of sucrose. Erythritol has been widely used in low-sugar, health care and other functional foods in recent years because of its low energy value, high tolerance, non-toxic side effects, edible for diabetics and non-cariogenic properties. , Chemical industry is also widely used. At present, the industrial production of erythritol is mainly realized through microbial fermentation. [0003] The mother liquor after multiple crystallization of erythritol refers to the brown-black mother liquor produced by fermented yeast liquid after two or more crystallization extractions during th...

Claims

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Application Information

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IPC IPC(8): C07C31/24C07C29/76
Inventor 孙鲁邱学良李雨李林庞颂于军伟
Owner FUTASTE PHARM CO LTD
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