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Method for preparing chitosan substrate film by self-deposition of micron gel

A technology of chitosan and base film, applied in the field of preparation of chitosan base film, can solve problems such as unfavorable application, film curling, etc., and achieve the effects of high water permeability, high compliance, and simplified preparation process

Inactive Publication Date: 2012-07-25
ZHEJIANG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The final result of these three methods is a dense film, which will swell and curl when absorbing water, which is not conducive to application
During the preparation process of method 2, it is easy to cause the curling of the film

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] (1) Take 2G dehydrate of 95%, a molecular amount of 100,000 shell polycan, add 200ml of quality concentration of 2%acetate solution, mix the room temperature until it is completely dissolved.Stir -foaming; filter the above solution, oscillate the ultrasound in the ultrasonic disperser, and add 5%sodium hydroxide aqueous solution to the solution until it is completely precipitated.The particle size of the chitosan micron gel is between 300 and 500 μm;

[0027] (2) Rinse the shells of the shells of glycogen micron gel suspension with derived water to a neutral pH = 7.4, filter, and obtain the shell polycanic micron water gel;

[0028] (3) Immersed the obtained chitosan micron gel into a propine solution with a 1%propylene gel in mass concentration. After 30 minutes, the shell glycogen gel was obtained by obtained obtained obtained obtained obtained obtained.

[0029] (4) Corresponding to the oblong alcohol -increased shell polycanic micron hydrogel, remove excess water, and c...

Embodiment 2

[0031] (1) Take 2G dehydrate of 85%and a molecular weight of 200,000 shell polysaccharides, add 200ml of quality concentration of 2%hydrochloride solution, stir at room temperature until fully dissolved, and distribute to the water solution of 1%(m / v).Stir -foaming; filter the above solution, oscillate the ultrasound in the ultrasonic disperser, and add 5%potassium hydroxide aqueous solution to the solution until it is completely precipitated.The particle size of the chitosan micron gel is between 100 and 300 μm;

[0032] (2) Rinse the shells and micron hydrogel of the shell to the neutral pH = 7.4 with the derived water.

[0033] (3) Immersed the obtained shell polycanic micron hydrogel in a mass concentration of 1%propylene glycol and 0.5%CACL 2 In the 1%seven -element solution, filter after 30 minutes, and get CACL 2 And pine or oblite -plastic plastic -plastic shell polycagin micron gel;

[0034] (4) CACL with step (3) steps (3) 2 Corporation of propylene glycol plastic glycog...

Embodiment 3

[0036] (1) Take 2G dehydrate of 75%and a molecular amount of 500,000 shell polycan, add 200ml of quality concentration of 2%acetic acid aquatic solution, stir at room temperature until it is completely dissolved.Stir -foaming; filter the above solution, oscillate the ultrasound in the ultrasonic disperser, and add 5%sodium hydroxide aqueous solution to the solution until it is completely precipitated.The particle size of the chitosan micron gel is between 100 and 300 μm;

[0037] (2) Rinse the shells and micron hydrogel of the shell to the neutral pH = 7.4 with the derived water.

[0038] (3) Immersed the obtained shell polycanic micron hydrogel in the aqueous solution containing 1%propylene glycol, 1%triaxin, and 0.5%nano -silver.Silver's propylene glycol plastic -plastic shell poly glycogen gel;

[0039] (4) Corresponding to the oblong -glycogenic hydraulus of oblong glycol containing trifle and nano -silver, removing excess water, and controlling the moisture content of the she...

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PUM

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Abstract

The invention discloses a method for preparing a chitosan substrate film by self-deposition of micron gel. The method comprises the following steps: dissolving chitosan into a diluted acid aqueous solution to prepare a chitosan acid solution; carrying out ultrasonic oscillation, and simultaneously dropwise adding a chitosan precipitating agent so as to separate out chitosan hydrogel; washing the chitosan hydrogel with deionized water until pH value is 7.4; and filtering to obtain chitosan micron hydrogel; and soaking the chitosan micron hydrogel into a glycerol aqueous solution or a glycerol aqueous solution containing a thrombin medicament or an antibacterial active matter, filtering, centrifuging, injecting into a mould, and drying under a vacuum condition. The method disclosed by the invention is simple in preparation process; the prepared chitosan film is loose in structure and has high water permeability and high compliance, and does not curl when contacting water; and various hemostatic or antibacterial medicament active components can be conveniently loaded in chitosan, and the prepared chitosan film is a good medicament carrier.

Description

Technical field [0001] The present invention involves a method of preparing a chitosanogenic membrane, especially the method of the micron gel self -deployed chitosaccharides. Background technique [0002] Chitosan (Chitosan), scientific name (1,4) -2-amino-2-deoxy-β-D-glucose, is a metharine (N-acetyl-2-acetyl amin amin amin amino-D-glucoseA biopopolifiers obtained by the acetylization reaction of the keys), the molecular chain usually contains two structured units: N-acetylamide glucose and N-amino glucose. The proportion of the two is dehydratedDifferent and different. [0003] Chitin is derived from the ocean shells and algae, and shells of chitosan are dehycethlcetyl products of chitin.A natural weak alkaline biosuto has excellent biocompatibility, non -toxic, antibacterial, hemostasis, and promoting wound healing.At present, the application of chitosan is increasingly widely used, including medical, agriculture, cosmetics and other fields.Among them, the application in the ...

Claims

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Application Information

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IPC IPC(8): C08J5/18C08J3/075C08L5/08A61K47/36
Inventor 孙永富胡巧玲
Owner ZHEJIANG UNIV
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