Cytidine disodium triphosphate suspension powder injection and preparation method thereof
A technology of cytidine triphosphate disodium and powder injection, which is applied in the fields of pharmaceutical formulation, powder delivery, and medical preparations containing active ingredients, and can solve the problems of affecting the efficacy and safety of drugs, loss of activity, and easy breakage, etc., to achieve Improve bioavailability, improve therapeutic index, improve the effect of stability
- Summary
- Abstract
- Description
- Claims
- Application Information
AI Technical Summary
Problems solved by technology
Method used
Examples
Embodiment 1
[0031] Example 1 Cytidine triphosphate disodium suspension powder injection, calculated according to the prescription 20mg (1000 bottles):
[0032] Prescription: Cytidine Triphosphate Disodium 20g
[0033] Human Serum Albumin 60g
[0034] Mannitol 50g
[0035] Preparation Process:
[0036] (1) Dissolve 20 g of disodium cytidine triphosphate in ethyl formate to form solution A;
[0037] (2) Dissolve 60g of human serum albumin in 5% glucose aqueous solution to form solution B;
[0038] (3) Disperse solution B in solution A and shear at high speed for 2 minutes to form colostrum C;
[0039] (4) Forming a stable emulsion of colostrum C under high pressure and high shear force or cavitation;
[0040] (5) The emulsion is evaporated under reduced pressure to produce a colloidal system composed of protein-coated pharmacologically active substances, which is sterilized by filtration;
[0041] (6) Add 50 g of mannitol, freeze-dry to remove water, and prepare cyt...
Embodiment 2
[0047] Example 2 Cytidine triphosphate disodium suspension powder injection, calculated according to the prescription 40mg (1000 bottles):
[0048] Prescription: Cytidine Triphosphate Disodium 40g
[0049] Human Serum Albumin 200g
[0050] Sorbitol 100g
[0051] Preparation Process:
[0052] (1) Dissolve 40 g of disodium cytidine triphosphate in ethyl formate to form solution A;
[0053] (2) Dissolve 200g of human serum albumin in 0.9% sodium chloride aqueous solution to form solution B;
[0054] (3) Disperse solution B in solution A and shear at high speed for 3 minutes to form colostrum C;
[0055] (4) Forming a stable emulsion of colostrum C under high pressure and high shear force or cavitation;
[0056] (5) The emulsion is evaporated under reduced pressure to produce a colloidal system composed of protein-coated pharmacologically active substances, which is sterilized by filtration;
[0057] (6) Add 100 g of sorbitol, freeze-dry to remove water, ...
Embodiment 3
[0063] Example 3Cytidine triphosphate disodium suspension powder injection, calculated according to the prescription 10mg (1000 bottles):
[0064] Prescription: Cytidine Triphosphate Disodium 10g
[0065] Human Serum Albumin 45g
[0066] Lactose 35g
[0067] Preparation Process:
[0068] (1) Dissolve 10 g of disodium cytidine triphosphate in ethyl formate to form solution A;
[0069] (2) Dissolve 45g of human serum albumin in 5% glucose aqueous solution to form solution B;
[0070] (3) Disperse solution B in solution A and shear at high speed for 4 minutes to form colostrum C;
[0071] (4) Forming a stable emulsion of colostrum C under high pressure and high shear force or cavitation;
[0072] (5) The emulsion is evaporated under reduced pressure to produce a colloidal system composed of protein-coated pharmacologically active substances, which is sterilized by filtration;
[0073] (6) Add 35 g of lactose, freeze-dry to remove water, and prepare cytid...
PUM

Abstract
Description
Claims
Application Information

- R&D Engineer
- R&D Manager
- IP Professional
- Industry Leading Data Capabilities
- Powerful AI technology
- Patent DNA Extraction
Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.
© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com