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Chinese medicinal composition with blood sugar reducing effect, and preparation method and application thereof

A composition and technology of traditional Chinese medicine, applied in the field of traditional Chinese medicine composition with blood sugar lowering effect and its preparation, can solve the problems of inability to give full play to the advantages of traditional Chinese medicine in treating diabetes, blood phase liver function, kidney function damage, diabetes curative effect is not significant, etc., to achieve prescription Reasonable design, non-toxic and side effects, and strict compatibility

Inactive Publication Date: 2013-09-04
张玲
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the side effects of these oral chemicals are mainly manifested in the damage to the blood phase, liver function, and kidney function, which will cause diabetic cardiovascular and cerebrovascular complications, prone to hypoglycemia, irritating the gastrointestinal tract, and producing anorexia , nausea, vomiting, and even diarrhea
Therefore, it is urgent to choose high-efficiency and long-term use without any toxic and side effects, reliable curative effect, and convenient hypoglycemic drugs to take. Chinese medicine has certain curative effect for treating diabetes. The efficacy of traditional Chinese medicine preparations in treating diabetes is not significant, and the advantages of traditional Chinese medicine in treating diabetes cannot be brought into play

Method used

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  • Chinese medicinal composition with blood sugar reducing effect, and preparation method and application thereof
  • Chinese medicinal composition with blood sugar reducing effect, and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] Embodiment 1: the preparation of granule

[0026] Take 30g of Cornus officinalis, 40g of mulberry leaves, 10g of Trichosanthes and 30g of Yemazhui medicinal materials, add water to decoct twice, add water for the first time to be 8 times the weight of the medicinal materials, decoct for 1.5h, and add water for the second time to equal the weight of the medicinal materials. 6 times the amount, decocted for 1 hour, combined the decoction, filtered, concentrated the filtrate to a relative density of 110 (65°C), added an appropriate amount of ethanol to make the alcohol content (volume fraction) reach 65%, stirred, stood still for 24 hours, and filtered , the filtrate recovers ethanol and concentrates it to an extract with a relative density of 1.20 (65°C), which is spray-dried (conditions are that the inlet air temperature is 100°C, the outlet air temperature is 80°C, the material temperature is 70°C, and the atomization pressure is 0.2 Mg Pa, spray speed is 5ml / s.), crush...

Embodiment 2

[0027] Embodiment 2: the preparation of tablet

[0028] Take 20g of Cornus officinalis, 30g of mulberry leaves, 5g of Trichosanthes and 20g of Yemazhui medicinal materials, add water to decoct twice, add water for the first time to 10 times the weight of the medicinal materials, decoct for 2 hours, and add water for the second time to 8 times the weight of the medicinal materials decocted for 1 hour, combined the decoction, filtered, the filtrate was concentrated to a relative density of 115 (65°C), added an appropriate amount of ethanol to make the alcohol content (volume fraction) reach 75%, stirred, stood still for 24 hours, filtered, and the filtrate Recover ethanol and concentrate to the extract with a relative density of 1.25 (65°C), and spray dry (conditions are that the inlet air temperature is 120°C, the outlet air temperature is 90°C, the material temperature is 80°C, and the atomization pressure is 0.3 MPa, The spray speed is 7.5 / s.), crushed into dry extract powder...

Embodiment 3

[0029] Embodiment 3: the preparation of oral liquid

[0030] Take 20g of Cornus officinalis, 20g of mulberry leaves, 5g of Trichosanthes and 20g of Yemazhui medicinal materials, add water to decoct twice, add water for the first time to 12 times the weight of the medicinal materials, decoct for 2 hours, add water for the second time to 10 times the weight of the medicinal materials Double the amount, decoct for 2 hours, combine the decoction, filter, concentrate the filtrate to a relative density of 1.20 (65°C), add an appropriate amount of ethanol to make the alcohol content (volume fraction) reach 85%, stir, let stand for 24 hours, filter, The ethanol is recovered from the filtrate and concentrated to an extract with a relative density of 1.30 (65°C), spray-dried (conditions are that the inlet air temperature is 100°C, the outlet air temperature is 90°C, the material temperature is 90°C, and the atomization pressure is 0.4 MPa , spray speed is 10 / s.), crushed into dry extrac...

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Abstract

The invention discloses a Chinese medicinal composition with a blood sugar reducing effect. The Chinese medicinal composition contains the following components in part by weight: 10 to 30 parts of common macrocarpium fruit, 20 to 40 parts of mulberry leaf, 5 to 10 parts of purple lythrum herb and 10 to 30 parts of lindley eupatorium herb, wherein the Chinese medicinal composition may be granules, tablets, oral liquid and capsules. The invention also discloses a preparation method for the Chinese medicinal composition. The method comprises the following steps of: decocting in water, concentrating, performing alcohol precipitation, spray-drying, crushing the obtained granules into dry extract powder, and adding auxiliary materials to prepare the required preparation. The invention also discloses application of the Chinese medicinal composition to the preparation of medicines with the blood sugar reducing effect.

Description

technical field [0001] The invention relates to a traditional Chinese medicine composition, in particular to a traditional Chinese medicine composition with the effect of lowering blood sugar, a preparation method and application thereof. Background technique [0002] According to WHO's conservative estimate, by 2025, the global incidence of diabetes will increase to 3% to 5%, estimated to reach 300 million patients, and the age of patients will tend to be from 65 years old to 40 to 64 years old. Diabetes mellitus is an endocrine metabolic disease characterized by hyperglycemia due to absolute or relative insufficiency of insulin in the body. Among diabetic cases, about 5% are insulin-dependent diabetes mellitus (IDDM, type 1). Type 1 diabetes is caused by the abnormal response of pancreatic beta cells caused by viral infection in people with genetic predisposition or autoimmune deficiency, resulting in the production of pancreas in vivo. Insulin cells have been completely ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/605A61P3/10
Inventor 张玲
Owner 张玲
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