Liposome solid preparation of ozagrel

A technology of ozagrel hydrochloride and liposomes, which is applied in the field of medicine, can solve the problems of low bioavailability, long dissolution time, and affecting the therapeutic effect, and achieve high bioavailability, excellent dissolution, and good sustained-release effect Effect
CN102626388BInactive Publication Date: 2013-05-29HAINAN YONGTIAN PHARMA INST
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
HAINAN YONGTIAN PHARMA INST
Publication Date
2013-05-29
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention discloses a liposome solid preparation of ozagrel and a preparation method thereof. In the invention, an active ingredient ozagrel hydrochloride and a special combination of hydrogenated yolk lecithin, dioleoyl-phosphatidyl-ethanolamine, cholesteryl succinate, and Span 20 are prepared into a liposome, thereby greatly improving stability, dissolubility, and bioavailability of the drug, and having stable and lasting effect and obvious curative effect. According to the invention, product quality of the preparation is improved, and the toxic side effect is reduced.
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Description

technical field

[0001] The invention relates to a new preparation of ozagrel hydrochloride, in particular to ozagrel hydrochloride liposome and its solid preparation and preparation method, belonging to the technical field of medicine. Background technique

[0002] In recent years, a series of thromboembolic diseases such as cerebral thrombosis, myocardial infarction, peripheral arterial thrombosis, deep vein thrombosis, and pulmonary embolism have seriously threatened human health. According to statistics, the death caused by it has reached 51% of the total death toll in the world. Therefore, thrombus, the ghost in blood vessels, is the common opponent of specialist doctors and has become the greatest enemy of human health. The manifestations of thromboembolic disease range from head to toe. Cerebral vascular thrombosis can cause dysfunction of one side of the limbs of the patient, that is, hemiplegia, aphasia, visual and sensory impairment, coma, and can be disabled or f...

Claims

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