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Preparation methods of medical alpha-calcium sulfate hemihydrate powder and calcium sulfate artificial bone material

A technology of calcium sulfate hemihydrate and calcium sulfate, which is applied in the fields of calcium/strontium/barium sulfate, prosthesis, medical science, etc., can solve the problem that does not meet the requirements of mechanical properties of artificial bone repair materials, and is difficult to provide mechanical strength of bone repair parts , poor mechanical strength and other problems, to achieve good application prospects, effectively prolong the degradation time, and improve the compressive strength.

Active Publication Date: 2012-08-15
NINGBO INST OF MATERIALS TECH & ENG CHINESE ACADEMY OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] However, the clinically used calcium sulfate bone graft material still has the following defects: (1) its degradation rate is faster than the growth rate of new bone tissue, and the time for complete degradation and absorption in the body varies according to the implanted site, generally between 30 and 72 (2) The mechanical strength after curing is poor, and it is difficult to provide the mechanical strength required by the bone repair site; (3) It cannot form chemical bonds with the surrounding bone tissue at the initial stage of repair, showing weak biological activity
Although the Chinese invention patent application with the application number CN200510047452.6 provides a preparation process for α-calcium sulfate hemihydrate, the prepared α-calcium sulfate hemihydrate is in the shape of a long rod with a large particle size, which is not suitable for artificial bone repair. Material requirements for mechanical properties

Method used

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  • Preparation methods of medical alpha-calcium sulfate hemihydrate powder and calcium sulfate artificial bone material
  • Preparation methods of medical alpha-calcium sulfate hemihydrate powder and calcium sulfate artificial bone material
  • Preparation methods of medical alpha-calcium sulfate hemihydrate powder and calcium sulfate artificial bone material

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Experimental program
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Effect test

Embodiment 1

[0060] In this embodiment, the α-calcium sulfate hemihydrate powder is prepared by reacting calcium sulfate dihydrate in a reaction solution, which is a mixed solution of calcium chloride, absolute ethanol, succinic acid and distilled water. Wherein, the mass ratio of calcium chloride to distilled water is 0.3, the volume ratio of absolute ethanol to distilled water is 0.5, the mass ratio of succinic acid to distilled water is 0.0045, and the mass ratio of calcium sulfate dihydrate to reaction solution is 0.0355.

[0061] The concrete preparation method of this α-calcium sulfate hemihydrate powder comprises the steps:

[0062] (1) At room temperature, add 0.75g of succinic acid into 165ml of distilled water and ultrasonically disperse for 5 minutes, then add 50g of anhydrous calcium chloride and 82.5ml of absolute ethanol one by one, and stir thoroughly for 10 minutes each to obtain a uniform reaction solution.

[0063] (2) Pour the reaction solution obtained in step (1) into ...

Embodiment 2

[0075] In this embodiment, the α-calcium sulfate hemihydrate powder is prepared by reacting calcium sulfate dihydrate in the reaction solution, which is basically the same as the reaction solution in Example 1, except that absolute ethanol and The volume ratio of water is 1:1.

[0076] The specific preparation method of this α-calcium sulfate hemihydrate powder is basically the same as the preparation method in Example 1, except that in step (1), the volume ratio of dehydrated alcohol to water is 1, and the volume ratio of dehydrated alcohol is 1. The addition amount is 165ml, specifically comprises the following steps:

[0077] (1) At room temperature, add 0.75g of succinic acid into 165ml of distilled water and ultrasonically disperse for 5 minutes, then add 50g of anhydrous calcium chloride and 165ml of absolute ethanol one by one, and stir thoroughly for 10 minutes each to obtain a uniform reaction solution.

[0078] (2) is identical with (2) in embodiment 1;

[0079] (3...

Embodiment 3～7

[0090] In the following examples 3 to 7, the α-calcium sulfate hemihydrate powder is prepared by reacting calcium sulfate dihydrate in the reaction solution. The reaction solution is basically the same as in Example 1, except that the concentration of the calcium chloride solution or The volume ratio of absolute ethanol and water (see table 1 below for details).

[0091] Utilize this α-calcium sulfate hemihydrate powder and solidifying liquid to mix evenly, can prepare medical calcium sulfate artificial bone material after solidifying, its concrete steps are basically the same as embodiment 1, difference is the kind of solidifying liquid that adopts (see below for details Table 1). Table 1: Preparation conditions and properties of α-calcium sulfate hemihydrate powder and calcium sulfate artificial bone material in Examples 3-7

[0092]

[0093]

[0094] The phase of the α-calcium sulfate hemihydrate powder that above-mentioned making is analyzed, obtains similar figur...

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Abstract

The invention discloses preparation methods of medical alpha-calcium sulfate hemihydrate powder and a calcium sulfate artificial bone material, belonging to the field of medical biomaterials. According to the invention, alpha-calcium sulfate hemihydrate is prepared by adding anhydrous alcohol to a reactant liquid containing calcium chloride, a crystal modifier and distilled water, wherein the volume ratio of the anhydrous alcohol to the distilled water is 0.01-2, so that the crystal water of calcium sulfate dihydrate is partially removed in the reactant liquid. Due to the modification effect of the anhydrous alcohol, the grain morphology and size of the alpha-calcium sulfate hemihydrate powder are effectively improved, and isometric or approximately isometric alpha-calcium sulfate hemihydrate powder with high purity and uniform crystal structure and particle size distribution is obtained. A medical calcium sulfate artificial bone material prepared by mixing and curing the alpha-calcium sulfate hemihydrate powder with a curing liquid can effectively improve the compressive strength, prolong the degradation time and improve the biological performance, so that the medical calcium sulfate artificial bone material has high performance and good application prospects in the technical fields of medical bone transplantation and bone repair.

Description

technical field [0001] The invention belongs to the technical field of medical biomaterials, and in particular relates to a preparation method of α-calcium sulfate hemihydrate powder and calcium sulfate artificial bone material. Background technique [0002] Calcium sulfate has been studied as a bone graft substitute for more than 100 years. It has good biocompatibility and degradability, and is a good bone repair material. Calcium sulfate has sufficient sources and is easy to sterilize. It is widely used in bone defect filling in orthopedics, dentistry, and ENT. It can also be used as a carrier for antibiotics, pharmaceutical preparations, and growth factors. It can also play the role of drug delivery as a scaffold material. . [0003] The commercialized medical calcium sulfate product has the U.S. Wright company's British Encore company and German etc., is a highly pure crystal structure inorganic compound (CaSO 4 .1 / 2H 2 O). A large number of clinical applicatio...

Claims

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Application Information

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IPC IPC(8): C01F11/46A61L27/02A61L27/54
Inventor 黄庆徐华梓彭磊刘建莉潘宗友楼毅杨光永
Owner NINGBO INST OF MATERIALS TECH & ENG CHINESE ACADEMY OF SCI
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