Method for preparing substituted homotaurine from alpha, beta-unsaturated amide

A high taurine, unsaturated technology, applied in chemical instruments and methods, preparation of organic compounds, organic chemistry, etc., can solve the problems of raw material limitation, troublesome desalination and purification process, etc., and achieve the effect of simple operation
CN102659643AActive Publication Date: 2012-09-12BEIJING UNIV OF CHEM TECH
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
BEIJING UNIV OF CHEM TECH
Publication Date
2012-09-12

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Abstract

The invention provides a method for preparing substituted homotaurine from an alpha, beta-unsaturated amide. The method is characterized in that thioacetic acid and the alpha, beta-unsaturated amide undergo an addition reaction to produce corresponding 3-acetylthioacetamide and through reduction and oxidation, the substituted homotaurine is obtained. The method adopts simple and easily available raw materials, is convenient for operation, avoids a complicated desalting purification process, and is especially suitable for large-scale industrial production. The homotaurine can be used as a nutriment, a drug, an enzyme inhibitor, an antiseptic, a surfactant, a plant-growth regulator and a raw material of sulfonopeptides.
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Description

technical field

[0001] The invention belongs to the technical field of organic synthesis, and in particular relates to a preparation method of substituted homotaurine. Background technique

[0002] Homotaurine, or 3-aminopropanesulfonic acid, is an aminoalkylsulfonic acid isolated from Centipede lingulae, which is structurally similar to the neurotransmitter γ-aminobutyric acid, and it has been found to have Anticonvulsant efficacy of gamma-aminobutyric acid (Fariello, R. G.; Golden, G. T.; Pisa, M. Neurology 1982, 32 , 241). Hypertaurine can also prevent and treat sclerosis of the conjunctival sheath, prevent hair loss, treat alcohol dependence, inhibit the oxidation of catecholamines in the body, protect DNA from oxidative damage, improve memory, strengthen the heart, and lower blood pressure (Mayer, J. ; Cook, A.M. J. Bacteriol . 2009, 191 , 6052; Rouhani, S.; Dallava Santucci, J.; Bajenaru, O.; Emmanouilidis, E.; Tran, G.; Pharmacol., Biochem. Behav . 1998, 59 ,...

Claims

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