Method for preparing erythromycin thiocyanate
A technology of erythromycin thiocyanate and erythromycin, which is applied to the preparation of sugar derivatives, chemical instruments and methods, sugar derivatives, etc., can solve the problems of low yield, high production cost, complicated operation, etc., and achieve product High yield and purity, suitable for mass production, and simple operation
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Embodiment 1
[0016] The following examples are used to illustrate the present invention, but are not intended to limit the scope of the present invention. If not otherwise specified, the percentage sign "%" involved in the examples refers to the mass percentage; but the percentage of the solution, unless otherwise specified, refers to the grams of solute contained in 100ml of the solution. The preparation of embodiment 1 erythromycin thiocyanate
[0017] Preparation of erythromycin fermented liquid: using Streptomyces ruber (Streptomyces ruber) as fermentation strain, the preparation process is:
[0018] The seed tank culture medium is 6.0% of dextrin, 3.0% of soybean cake powder, 0.3% of ammonium sulfate, 1.0% of sodium chloride, 1.0% of calcium carbonate, and 2.0% of soybean oil, prepared with water. After the culture medium is sterilized, when the temperature of the tank drops to 34°C, insert the strain of Streptomyces rubrum into the seed tank by the differential pressure method. The...
Embodiment 2
[0025] The preparation of embodiment 2 erythromycin thiocyanate
[0026] The preparation method of erythromycin fermentation broth is the same as that described in Example 1.
[0027] 1) Take 170L of the above-mentioned erythromycin fermentation broth, the erythromycin content is 624.1g, heat it to 40°C, and filter it through a 0.01μm ceramic membrane. During the ceramic membrane filtration period, you need to add 425L water for dialysis. Concentrate to obtain 170L of membrane concentrate, add 1.47L of 20% sodium hydroxide solution to adjust the pH to 8.5.
[0028] 2) The alkaline membrane concentrate was passed through the treated resin column at a flow rate of 2BV / h to absorb impurities, and 171.47L of effluent was collected.
[0029] 3) Adjust the pH of the effluent to 10.3 with 20% sodium hydroxide solution, enter the extraction tower at a flow rate of 2.83ml / rev, and simultaneously feed butyl acetate into the extraction tower at a flow rate of 2.83ml / rev, stir, and colle...
Embodiment 3
[0032] The preparation of embodiment 3 erythromycin thiocyanate
[0033] The preparation method of erythromycin fermentation broth is the same as that described in Example 1.
[0034] 1) Take 55.7L of the above-mentioned erythromycin fermentation broth with a content of 223.5g of erythromycin, heat it to 45°C, and filter it through a 0.01μm ceramic membrane. The filter membrane was concentrated to obtain 55.7 L of membrane concentrate, and 250 ml of 20% sodium hydroxide solution was added to adjust the pH to 8.5.
[0035] 2) Pass the concentrated alkaline membrane solution through the treated resin column at a flow rate of 2BV / h to absorb impurities, and collect 55.95L of effluent.
[0036] 3) Adjust the pH of the effluent to 10.2 with 20% sodium hydroxide solution, enter the extraction tower at a flow rate of 2.83ml / rev, and simultaneously feed butyl acetate into the extraction tower at a flow rate of 2.83ml / rev, stir, and collect 4.6L of the upper layer Butyl acetate phase...
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