Multi-aperture nerve repairing tube and preparation method and application thereof

A nerve repair and multi-aperture technology, applied in the field of medical materials, can solve problems such as slow degradation, inability to maintain a stable structure, and poor plasticity of materials, and achieve good plasticity and mechanical properties, repair spinal nerve injuries, and good tissue compatibility sexual effect

Inactive Publication Date: 2012-09-26
TIANXINFU (BEIJING) MEDICAL APPLIANCE CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

These materials have certain characteristics of promoting the adhesion, differentiation and growth of various types of nerve cells, and can promote the formation of synapses between neuron cells, but the repair effect of these materials is not ideal enough, and all have their own shortcomings, such as Slow degradation rate, poor material plasticity, etc.
[0005] In the prior art, Chinese patent application 00810000.4 provides a nerve conduit made of polyester material. The lumen is filled with collagen hydrochloric acid solution and freeze-dried to obtain a collagen body content with fine fibrosis. However, this method is difficult to obtain a nerve conduit with axial Through multi-channel structure
Chinese patent application 02105864.4 placed a folded and curled porous polyester film with a concave-convex surface in a hollow tube made of polyester material to increase the surface area of ​​the cavity and make a multi-channel nerve regeneration catheter. However, the contents of the catheter Cannot maintain a stable structure in the free state
However, this method needs to prepare chitosan tubes in advance, and the mechanical properties, permeability, pore size and porosity of the prepared catheters need to be improved

Method used

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  • Multi-aperture nerve repairing tube and preparation method and application thereof
  • Multi-aperture nerve repairing tube and preparation method and application thereof
  • Multi-aperture nerve repairing tube and preparation method and application thereof

Examples

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Effect test

Embodiment 1

[0034] The preparation method of the multi-aperture nerve repair catheter of the present invention takes a collagen slurry concentration of 5%, a repair tube length of 30mm, a diameter of 8mm, a microtube diameter of 0.6mm, and a model containing 16 parallel microtube channels as an example. The production method includes the following steps:

[0035] 1. Preparation of slurry

[0036] 1.10.05M acetic acid solution preparation

[0037] Take 2-6ml of glacial acetic acid into a 1000ml conical flask, add sterile water to make the volume to 1000ml, and mix well to prepare a 0.05M acetic acid solution.

[0038] 1.2 Preparation of slurry

[0039] Weigh 0.5g of collagen, first add 2ml of 0.05M acetic acid solution, put it in a grinder to fully grind and crush; then add 8ml of 0.05M acetic acid solution to prepare a 5% collagen slurry. Add the prepared collagen slurry to a 20ml syringe, then connect another empty syringe and pull repeatedly until the collagen is completely dissolved.

[0040] 2...

Embodiment 2

[0057] Taking a model with a collagen slurry concentration of 5%, a repair tube having a diameter of 14mm, a length of 55mm, and a channel diameter of 1.2mm, containing 16 parallel microtubule channels as an example, the manufacturing method includes the following steps:

[0058] 1. Preparation of slurry

[0059] 1.10.05M acetic acid solution preparation

[0060] Take 2-6ml of glacial acetic acid into a 1000ml conical flask, add sterile water to make the volume to 1000ml, and mix well to prepare a 0.05M acetic acid solution.

[0061] 1.2 Preparation of slurry

[0062] Weigh 0.5g of collagen, first add 2ml of 0.05M acetic acid solution, put it in a grinder to fully grind and crush; then add 8ml of 0.05M acetic acid solution to prepare a 5% collagen slurry. Add the prepared collagen slurry to a 20ml syringe, then connect another empty syringe and pull repeatedly until the collagen is completely dissolved.

[0063] 2. Centrifugal

[0064] Centrifuge the prepared slurry at 4000rpm for 60min ...

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Abstract

The invention relates to a multi-aperture nerve repairing tube and a preparation method and application thereof. The multi-aperture nerve repairing tube is a cylinder with a length-diameter ratio of 0.1-1, and multiple microtube channels are axially distributed in parallel inside; and the ratio of the diameter of each microtube channel to the diameter of the cylinder is 0.04-0.2. The multi-aperture nerve repairing tube provided by the invention has good histocompatibility, proper and controllable degradation absorbability, low antigenicity and good plasticity and mechanical properties. The multi-aperture nerve repairing tube provided by the invention can effectively promote the repair of the injured spinal nerve, and also can be used as a cell transplantation carrier to carry different nerve growth factors and stem cells for repairing the spinal nerve injury. The multi-aperture nerve repairing tube provided by the invention is favorable for the intrusion, differentiation and growth of the nerve cell; and the tubular biomaterial is connected with the far and near broken ends of the nerve, and can induce the axon of the regenerated nerve to grow from the near end to the far end along the tube cavity and stimulate the growth of the neuron of the organism. The multi-aperture nerve repairing tube can be used for promoting the repair of spinal nerves.

Description

Technical field [0001] The invention relates to the field of medical materials, in particular to a multi-aperture nerve repair tube and a preparation method thereof. Background technique [0002] Functional recovery below the level of spinal cord injury is a major problem in medical treatment today. Materials scientists and doctors have tried to apply a variety of materials and methods to solve this problem. The rise of tissue engineering technology has brought new hope for the recovery of spinal cord injury. The selection and construction of scaffold materials as the three elements of tissue engineering is the key to the success of tissue engineering. [0003] Using nerve conduits as stents and using tissue engineering technology to repair peripheral nerve and spinal cord injuries is an important measure developed in recent years. This tubular material connects the distal and proximal ends of the nerve, which can induce regenerated nerve axons to grow from the proximal end to the...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61F2/04A61L27/24A61L27/56
Inventor 康承桂
Owner TIANXINFU (BEIJING) MEDICAL APPLIANCE CO LTD
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