Method of using ketoxime ether for preparation of alkoxyl amine hydrochloride and alkoxyl amine hydrochloride preparation method

A technology of hydrocarbyloxyamine hydrochloride and ketoxime ether, which is applied in the field of preparing hydrocarbyloxyamine hydrochloride and hydrocarbyloxyamine hydrochloride from ketoxime ether, and can solve the operation danger, yield and low cost. problems such as low yield, to achieve the effect of reducing production costs
CN102911079AActive Publication Date: 2013-02-06宁波四明化工有限公司
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
宁波四明化工有限公司
Publication Date
2013-02-06

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Abstract

The invention relates to a method of using ketoxime ether for preparation of alkoxyl amine hydrochloride. The method includes: continuously injecting acetoxime ether or diacetylmonoxime ether into a rectifying tower from a first feeding port, continuously injecting hydrochloric aqueous solution into the rectifying tower from a second feeding port, and separating out alkoxyl amine hydrochloride from tower bottom solution of the rectifying tower, wherein the number of plates or the number D1 of theoretical plates between the first feeding port and the tower bottom and the number of plates or the number D2 of theoretical plates between the second feeding port and the tower bottom respectively account for 30-80% of the total number of plates or the number of theoretical plates of the rectifying tower, and D1 is smaller thanD2. According to the method, extra organic solvents are not needed while target products can be obtained with high purity and high yield as reaction and separation are integrated, and steps for independent separation are reduced, so that production cost can be reduced.
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Description

technical field

[0001] The invention relates to a method for preparing alkoxyamine hydrochloride from ketoxime ether, and a preparation method for alkoxyamine hydrochloride. Background technique

[0002] Hydroxyl amine hydrochloride, also known as O-substituted hydrocarbyl hydroxylamine hydrochloride, its general formula is H 2 NOR 1 HCl, where R 1 can be C 1 -C 6 Alkyl, C 2 -C 6 Alkenyl, C 7 -C 13 Aryl groups and halides of these groups (halogen can be, for example, Br, Cl, etc.).

[0003] Alkoxylamine hydrochloride is a class of widely used and expensive organic synthesis intermediates. This type of compound can be used as an alkoxyamination reagent to introduce alkoxylamine groups into organic synthesis and new drug production. Ketone compounds (especially steroids); can be used as intermediates in the production of drug cefuroxime side chains and pesticides such as benzotrione, clethodim, sethoxydim and other herbicides, and can also be used as new medicines and...

Claims

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