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Turpinia arguta leaf total flavonoid ethanol reflux extract, preparation method and uses thereof

A technology of ethanol reflux extraction and Radix Radix et Rhizoma, applied in the directions of drug combination, pharmaceutical formula, plant raw material, etc., can solve problems such as high price, and achieve the effects of reducing infection, preventing and treating influenza and its complications

Inactive Publication Date: 2013-02-13
JIANGXI SHANXIANG PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Western medicine "Oseltamivir Phosphate (Tamiflu, (3R, 4R, 5S)-4-Acetamide-5-Amino-3(1-Propoxyethyl)-1-Cyclohexene-1 Carboxylic Acid Ethyl Phosphate "Salt)" is a neuraminidase inhibitor, which has a specific inhibitory effect on the entry of influenza virus into cells, but it is not only expensive, but also some patients experience vomiting, nausea, insomnia, headache, abdominal pain, diarrhea, dizziness, fatigue, Side effects such as nasal congestion, sore throat, and coughing

Method used

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  • Turpinia arguta leaf total flavonoid ethanol reflux extract, preparation method and uses thereof
  • Turpinia arguta leaf total flavonoid ethanol reflux extract, preparation method and uses thereof
  • Turpinia arguta leaf total flavonoid ethanol reflux extract, preparation method and uses thereof

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Effect test

Embodiment 1

[0029] Preparation method: take the round leaves of Shanxiang, use 5 times the volume of 90% ethanol as the extraction solvent, reflux extraction once for 3 hours, combine the extracts, filter, recover the ethanol from the filtrate, and absorb the aqueous solution with a non-polar macroporous adsorption resin. Use 10% ethanol to elute to remove impurities, and then elute with 70% ethanol of 7 times the volume of the column, collect the eluent, recycle ethanol, concentrate, dry, and obtain the ethanol reflux extract of the total flavonoids of Shanxiang round leaves, wherein the total flavonoids The content is 51.6%, containing privetin, rhodorin and hyperoside up to 15%, 5% and 4% respectively.

Embodiment 2

[0031]Preparation method: Take the round leaves of Shanxiang, use 14 times the volume of 45% ethanol as the extraction solvent each time, reflux extraction once for 2 hours, combine the extracts, filter, recover ethanol from the filtrate, and use non-polar macroporous adsorption resin for the aqueous solution Adsorption, eluting with 15% ethanol to remove impurities, and then eluting with 50% ethanol of 6 times the volume of the column, collecting the eluate, reclaiming ethanol, concentrating, drying, and obtaining the ethanol reflux extract of the total flavonoids of Cymbidium flavonoids, wherein The total flavonoid content is 55.1%, containing 8%, 12%, and 5% of privetin, rhodorin, and hyperoside, respectively.

Embodiment 3

[0033] Preparation method: Take the round leaves of Shanxiang, each time use 12 times the volume of 50% ethanol as the extraction solvent, reflux extraction twice, each time for 1.5 hours, combine the extracts, filter, recover ethanol from the filtrate, and use non-polar macroporous Adsorbed by adsorption resin, eluted with 18% ethanol to remove impurities, then eluted with 55% ethanol with 5 times the volume of the column, collected the eluate, recovered ethanol, concentrated, dried, and obtained the ethanol reflux extract of the total flavonoids of Rhizoma chinensis , the total flavonoid content is 59.6%, containing privetin, rhodorin, and hyperoside respectively reaching 11%, 7%, and 9%.

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Abstract

The present invention relates to uses of a turpinia ternate leaf total flavonoid ethanol reflux extract in preparation of drugs for neuraminidase inhibition, wherein the turpinia ternate leaf total flavonoid ethanol reflux extract is prepared by carrying out ethanol reflux extraction on turpinia ternate leaves. The extraction method comprises: taking turpinia ternate leaves; adding 30-90% ethanol in a Turpinia arguta / ethanol (W / V) ratio of 1: (5-15) to carry out reflux extraction 1-3 times, wherein each reflux extraction is performed for 1-3 hours; filtering; mixing the obtained filtrates, and carrying out ethanol recovery on the mixed filtrate; adopting a non-polar macroporous absorption resin to absorb the aqueous solution; adopting ethanol having a content of less than 20% to carry out elution to remove impurities; then adopting 25-90% ethanol to carry out elution, collecting the obtained eluent, and recovering ethanol; and carrying out concentration and drying to obtain the turpinia ternate leaf total flavonoid ethanol reflux extract.

Description

technical field [0001] The invention relates to an ethanol reflux extract of total flavonoids from the leaves of Rhizoma chinensis, a preparation method and application thereof. Background technique [0002] At present, influenza virus is becoming more and more serious, and influenza virus is closely related to respiratory diseases and systemic diseases caused by it. my country is one of the countries with high incidence of influenza. Not only has a large population, but also living habits are conducive to the transmission of influenza virus. The average number of episodes ranged from 0.3 to 0.7, and 2 to 4 in key groups. Influenza poses a serious threat to human beings, especially the emerging strains of influenza virus, which not only cause secondary infections of other microorganisms, but also directly lead to organ damage and allergic reactions leading to death. But there is no effective method and treatment means for treating influenza virus and its disease (influenza) ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/185A61P31/16A61P13/12A61P11/00A61K127/00
Inventor 唐春山王燕平张华敏谢宁吕武清杨小玲刘地发李志勇程帆
Owner JIANGXI SHANXIANG PHARMA
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