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Environment-friendly preparation method of multi-hydroxyl polymer molecular brush

A polyhydroxy polymer, an environmentally friendly technology, applied in the field of polymer chemistry, can solve the problems of toxic halides, high cost and toxic catalyst ligands, and achieve the effects of no toxicity, strong protein adsorption resistance, and easy-to-obtain raw materials

Inactive Publication Date: 2013-03-06
ZHENGZHOU UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0010] In order to achieve this goal, the present invention has designed polyhydric double bond monomers as functional polymerization monomers to make the polymer brushes have better hydrophilicity; The active halogen atom of the active halogen atom is replaced by a nucleophilic functional reagent, which not only solves the problem of the toxicity of the initiator halide, but also increases the functional group or functional reaction site; using non-toxic aminosilane as a ligand, and halogenated Cuprous coordination is used as a catalyst for this reaction to solve the problem of high cost and toxicity of catalyst ligands

Method used

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  • Environment-friendly preparation method of multi-hydroxyl polymer molecular brush
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  • Environment-friendly preparation method of multi-hydroxyl polymer molecular brush

Examples

Experimental program
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Effect test

Embodiment 1

[0031] 1) Surface treatment of the substrate: place the silicon substrate in a mixed solution with a volume ratio of concentrated sulfuric acid and hydrogen peroxide of 7:3, and after treatment at about 90° C. for 90 minutes, place the silicon substrate in acetone and water for sonication for 10 minutes. Rinse with water, and finally blow dry the surface of the substrate with nitrogen to obtain a hydroxylated silicon substrate Si-OH, such as figure 1 shown.

[0032] 2) Assembly of the aminosilane coupling agent: The newly prepared surface hydroxylated substrate was placed in 30 ml of a toluene solution containing 2.1 mmol of 3-aminopropyltriethoxysilane, heated to 80°C, and reacted for 24 hours. Take out the substrate, rinse the substrate with toluene, methanol, water, and acetone three times in turn, and blow dry the surface of the substrate with nitrogen to obtain a silane-modified silicon substrate Si-APTES, such as figure 1 shown.

[0033] 3) Modification of initiator: t...

Embodiment 2

[0037] 1) Surface treatment of the substrate: place the silicon substrate in a mixed solution with a volume ratio of concentrated sulfuric acid and hydrogen peroxide of 7:3, and after treatment at about 90° C. for 90 minutes, place the silicon substrate in acetone and water for sonication for 10 minutes. Rinse with water, and finally blow dry the surface of the substrate with nitrogen to obtain a hydroxylated silicon substrate Si-OH, such as figure 1 shown.

[0038] 2) Assembly of the aminosilane coupling agent: The newly prepared surface hydroxylated substrate was placed in 30 ml of a toluene solution containing 2.1 mmol of 3-aminopropyltriethoxysilane, heated to 80°C, and reacted for 24 hours. Take out the substrate, rinse the substrate with toluene, methanol, water, and acetone three times in turn, and blow dry the surface of the substrate with nitrogen to obtain a silane-modified silicon substrate Si-APTES, such as figure 1 shown.

[0039] 3) Modification of initiator: t...

Embodiment 3

[0043] 1) Surface treatment of the substrate: place the silicon substrate in a mixed solution with a volume ratio of concentrated sulfuric acid and hydrogen peroxide of 7:3, and after treatment at about 90° C. for 90 minutes, place the silicon substrate in acetone and water for sonication for 10 minutes. Rinse with water, and finally blow dry the surface of the substrate with nitrogen to obtain a hydroxylated silicon substrate Si-OH, such as figure 1 shown.

[0044] 2) Assembly of the aminosilane coupling agent: The newly prepared surface hydroxylated substrate was placed in 30 ml of a toluene solution containing 2.1 mmol of 3-aminopropyltriethoxysilane, heated to 80°C, and reacted for 24 hours. Take out the substrate, rinse the substrate with toluene, methanol, water, and acetone three times in turn, and blow dry the surface of the substrate with nitrogen to obtain a silane-modified silicon substrate Si-APTES, such as figure 1 shown.

[0045] 3) Modification of initiator: t...

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Abstract

The invention relates to an environment-friendly preparation method of multi-hydroxyl polymer molecular brush, belonging to the technical field of the synthesis of polymer. The multi-hydroxyl polymer brush which is good in protein adsorption resistance and easily modified by a bio-molecular detection probe is synthesized on the surface of a solid support material by surface-initiated atom transfer radical polymerization under the environment-friendly conditions, i.e. room temperature, pure water, nontoxicity and the like. The preparation method of the multi-hydroxyl polymer molecular brush comprises the following steps of: surface treatment of a substrate, assembly of an amino silane coupling agent, modification of an initiator, preparation of the multi-hydroxyl polymer molecular-modified substrate, and functional modification of the active halogen atom at the tail end of the polymer. The polymerization of the environment-friendly preparation method can be operated under the full water phase and the room temperature, and is simple in technology, non-toxic and environment-friendly; the end group of the obtained molecular brush can be functionally modified; and the polymer contains a mass of end hydroxyl, so that the molecular brush is good in water solubility, high in protein adsorption resistance, and suitable for biology, medicine, drug and food safety detection kits, biological drug carriers, heterogenous catalyst carriers, water absorbing materials and the like.

Description

technical field [0001] The invention relates to a preparation method of an environment-friendly polyhydroxy polymer molecular brush, belonging to the technical field of polymer chemistry. technical background [0002] The polymer brush is an ultra-thin polymer coating formed by connecting one end of the polymer molecular chain to the interface or the surface of the substrate. In the case of high grafting density, due to the characteristics of small distance, high density and regular size between adjacent molecular chains, steric repulsion causes the polymer molecular chains to extend outwards, so that the surface-connected polymer molecular chains become " brush" configuration. Polymer brushes have become a research hotspot in polymer chemistry because of their unique structural characteristics (accurate and flexible control of nanoscale, volume, structure, and shape) and broad application prospects. Drug delivery, catalysis, preparation of nanowires, biosensors, surface m...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08F292/00C08F220/58C08F4/58C08F2/10C08F8/20
Inventor 李铁生许文俭张娜蔡丽丽赵娜付志华吴养洁崔学晨
Owner ZHENGZHOU UNIV
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