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A kind of bee venom composition with anti-wrinkle effect

A composition and technology of bee venom, applied in the direction of skin care preparations, cosmetics, cosmetic preparations, etc., can solve the problems of potential safety hazards, insignificant anti-wrinkle effects, etc., to ensure safety, simplify the purification process of bee venom, and reduce molecular weight small effect

Active Publication Date: 2014-10-15
SOUTH CHINA SEA INST OF OCEANOLOGY - CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The purpose of the present invention is to solve the problems that the existing anti-wrinkle cosmetics have potential safety hazards, can only act on the surface layer of the skin, cannot penetrate deep into the dermis or even muscle tissue, and have insignificant anti-wrinkle effects, and provide a safer anti-wrinkle cosmetic that can act at the same time. A bee venom composition with anti-wrinkle effect for deep wrinkle removal in the epidermis, dermis and muscle tissue.

Method used

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  • A kind of bee venom composition with anti-wrinkle effect
  • A kind of bee venom composition with anti-wrinkle effect

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Experimental program
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Effect test

Embodiment 1

[0036] The crude wasp venom was collected by a bee venom collector, fully dissolved in 25 volumes of water, centrifuged at 8000g for 15 minutes, the supernatant was ultrafiltered through an ultrafiltration membrane with a molecular weight cutoff of 10000Da, and the filtrate was freeze-dried to obtain bee venom.

[0037] The bee venom composition with wrinkle-removing effect of this embodiment is based on 100% of the total mass percentage and consists of the following components:

[0038] Phase A: Carbomer 0.2%, glycerol 4%, propylene glycol 3%, the balance of deionized water.

[0039] Phase B: Cetearyl Ether-2 1.5%, Cetearyl Ether-21 2%, Jojoba Oil 3%, Cetearyl Alcohol 2%, Glyceryl Monostearate 1%, Caprylic Acid / Capric triglyceride 4%, ethylhexyl palmitate 3%, polydimethylsiloxane 2%, isopropyl myristate 3%, and ethyl paraben 0.1%.

[0040] Phase C: 0.1% bee venom (added in the form of a 50% bee venom solution with deionized water).

[0041] Phase D: Azone / PEG-40 hydrogenated castor o...

Embodiment 2

[0045] A bee venom collector was used to collect the crude bee venom, add 10 times the volume of water to fully dissolve it, centrifuge at 5000g for 30 min, the supernatant was ultrafiltered through an ultrafiltration membrane with a molecular weight cutoff of 10,000Da, and the filtrate was freeze-dried to obtain bee venom.

[0046] The bee venom composition with wrinkle-removing effect of this embodiment is based on 100% of the total mass percentage and consists of the following components:

[0047] Phase A: Carbomer 0.1%, glycerol 5%, propylene glycol 3%, the balance of deionized water.

[0048] Phase B: Cetearyl Ether-2 1.2%, Cetearyl Ether -21 1.5%, Hydrogenated Polyisobutylene 3%, Caprylic / Capric Triglyceride 3%, Ethylhexyl Palmitate 3% , Polydimethylsiloxane 2%, ethyl paraben 0.1%.

[0049] Phase C: Bee Venom 2% (added in powder form).

[0050] Phase D: Azone / PEG-40 hydrogenated castor oil 1%, triethanolamine 0.1%, phenoxyethanol / methyl paraben / butyl paraben / ethyl paraben / propyl ...

Embodiment 3

[0054] The crude wasp venom was purchased from Wuhan Yimin Bee Products Co., Ltd., added 30 times the volume of water to fully dissolve it, centrifuged at 10000g for 10 minutes, the supernatant was ultrafiltered through an ultrafiltration membrane with a molecular weight cutoff of 10000Da, and the filtrate was freeze-dried to obtain bee venom .

[0055] The bee venom composition with wrinkle-removing effect of this embodiment is based on 100% of the total mass percentage and consists of the following components:

[0056] Phase A: Xanthan gum 0.4%, acrylate / C 10-30 Alkyl acrylate cross-linked polymer 0.6%, EDTA-2Na 0.1%, glycerol 5%, propylene glycol 5%, butanediol 5%, the balance of deionized water.

[0057] Phase B: bee venom 0.00001% (add it in the form of a 10% bee venom solution prepared with distilled water in advance), deionized water 20%.

[0058] Phase C: PEG-40 hydrogenated castor oil ester 1%, triethanolamine 0.2%, flavor 0.1%, phenoxyethanol / methyl paraben / butyl paraben / eth...

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Abstract

A bee venom composition with a wrinkle removing effect comprises a wrinkle removing cosmetic matrix component and comprises bee venom.

Description

Technical field: [0001] The invention belongs to the field of cosmetics, and specifically relates to a bee venom composition with wrinkle removing effect. Background technique: [0002] Aging is an irresistible natural process of life. It is affected by a variety of factors such as genetics, environment, and social psychology. Wrinkles are the external manifestations of body aging on the skin, which are related to skin relaxation, ultraviolet radiation, gravity, and repeated contraction of facial expression muscles. It is related to factors such as muscle tension. Generally speaking, the first wrinkles appear on the forehead and lower eyelid from the age of 25, fine fishtail wrinkles appear from the outer canthus at the age of 30, longitudinal wrinkles appear in front of the ears at 35 years old, and the wrinkles in front of the ears increase at the age of 40 years. Vertical wrinkles appear on the jaw downward. At the age of 45, the lower eyelid wrinkles are more obvious, and t...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K8/98A61K8/65A61K8/73A61Q19/08
CPCA61K8/987A61K8/65A61K8/735A61Q19/08
Inventor 陈华孙恢礼张偲潘剑宇蔡冰娜孙小钰
Owner SOUTH CHINA SEA INST OF OCEANOLOGY - CHINESE ACAD OF SCI