Injectable porous bone cement and preparation method thereof

A porous bone and injectable technology, applied in medical science, prosthesis, etc., can solve the problems of bone cement curing time prolongation, leakage, etc., and achieve the effect of easy implementation, simple process, and superior comprehensive performance

Inactive Publication Date: 2013-03-27
SHANGHAI NAT ENG RES CENT FORNANOTECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the addition of such substances often prolongs the curing time of the bone cement, resulting in varying degrees of leakage problems still exist

Method used

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  • Injectable porous bone cement and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] Example 1: Add commercial calcium carbonate with a mass fraction of 6.5% and anhydrous sodium sulfate powder between 300-400 mesh with a mass fraction of 4.5% to the β-tricalcium phosphate bone cement powder, use absolute ethanol as the medium, and rotate at a speed of 500 rpm, ball milling for 12 h, centrifugation, heating and drying, and crushing to obtain bone cement powder. Prepare an aqueous solution with a mass fraction of chitosan of 2%, a mass fraction of hydroxypropylmethylcellulose of 1%, and a mass fraction of citric acid of 20% as a solidification solution. The bone cement powder and curing liquid were mixed at a solid-to-liquid ratio of 1 g: 0.45 ml to prepare a fast-curing, collapse-resistant injectable porous bone cement. The initial setting time was determined to be 25 minutes according to the standard ASTM C191. After the curing reaction was carried out for 1 hour, it did not collapse when exposed to water. It was cured for 24 hours at a temperature of ...

Embodiment 2

[0025] Example 2: To the mixed powder of β-tricalcium phosphate / hydroxyapatite (mass ratio 7:3), add commercial calcium carbonate with a mass fraction of 6.5% and anhydrous calcium carbonate with a mass fraction of 4.5% between 300-400 mesh Sodium sulfate powder, with absolute ethanol as the medium, ball milled at 500 rpm for 12 h, centrifuged, heated and dried, and mashed to obtain bone cement powder. Prepare an aqueous solution with a mass fraction of chitosan of 0.05%, a mass fraction of hydroxypropyl methylcellulose of 3%, and a mass fraction of citric acid of 20% as a solidification solution. The bone cement powder and curing liquid were mixed at a solid-to-liquid ratio of 1 g: 0.5 ml to prepare a fast-curing, collapse-resistant injectable porous bone cement. The initial setting time was 22 minutes as measured by the standard ASTM C191. After the curing reaction was carried out for 1 h, it did not collapse when exposed to water, and was cured for 24 h at a temperature of ...

Embodiment 3

[0026] Example 3: Adding 8% mass fraction of commercial calcium carbonate and 5% mass fraction of anhydrous calcium carbonate between 300-400 mesh to the mixed powder of β-tricalcium phosphate / hydroxyapatite (mass ratio 7:3) Sodium sulfate powder, with absolute ethanol as the medium, ball milled at 500 rpm for 12 h, centrifuged, heated and dried, and mashed to obtain bone cement powder. Prepare an aqueous solution with a mass fraction of chitosan of 2%, a mass fraction of hydroxypropylmethylcellulose of 1%, and a mass fraction of citric acid of 30% as a solidification solution. The bone cement powder and curing liquid were mixed at a liquid-solid ratio of 0.5 ml: 1 g to prepare a fast-setting, collapse-resistant injectable porous bone cement. The initial setting time was 13 minutes as measured by the standard ASTM C191. After the curing reaction was carried out for 45 minutes, it did not collapse in contact with water, and was cured for 24 hours at a temperature of 37 °C and a...

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Abstract

The invention relates to injectable porous bone cement and a preparation method thereof, and belongs to the field of preparation of a biomedical material. The bone cement takes carbonate as a solid foaming agent, sulfate as a curing accelerator, and chitosan and hydroxypropyl methyl cellulose as bi-component cross-linking agents; during the preparation of injectable porous bone cement, the coagulation time is 5-25min; the bone cement is not defeated and dispersed after being solidified for 20min to 2h; a cured product is provided with 100-1000-microns communicated holes; and the porosity is 1-70%, and the compressive strength is 0.5-40MPa. The preparation method provided by the invention is simple in process, and easy to implement; and the prepared injectable porous bone cement is excellent in overall performance, and can be produced on a large scale.

Description

technical field [0001] The invention relates to an injectable porous bone cement and a preparation method thereof. In particular, a fast-curing, anti-collapse injectable porous bone cement and a preparation method thereof. Background technique [0002] The ideal bone cement needs to meet good injectability, ease of operation (low curing temperature and short curing time), collapse resistance, certain mechanical strength, suitable micropore and macropore structure, and good biocompatibility properties such as sex, osteoinductivity, osteoconductivity, bioactivity, and degradability [Low KL, et al, Journal of Biomedical Materials Research Part B-Applied Biomaterials., 2010]. [0003] When injectable bone cement is used for bone repair, in order to realize the ingrowth of cells and blood vessels and the reconstruction of bone tissue, the bone cement should preferably have a certain macroporous structure. The traditional method of preparing large pores with injectable bone ceme...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/56A61L27/20A61L27/02A61L27/12
Inventor 闫策钟建金彩虹何丹农
Owner SHANGHAI NAT ENG RES CENT FORNANOTECH
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