Crystal preparation method of creatine phosphate sodium

Abstract

The invention discloses a crystallizing method for preparing high-purity creatine phosphate sodium. The crystallizing method comprises the following steps of: dissolving a creatine phosphate sodium crude product in water to prepare a 0.5-1.1 g / ml creatine phosphate sodium aqueous solution, continuously stirring for 30-60 minutes to decolor; after filtering, transferring a filtrate into a crystallizer, controlling a system temperature to be within 5-45 DEG C, and adding an alcohol or ketone organic solvent to perform solvent-out crystallization; after crystallizing, and separating through filtering, washing with a solvent and drying to obtain a creatine phosphate sodium product. The creatine phosphate sodium crystal provided by the invention is high in crystallinity degree, complete in product crystal habit, and uniform in particle size distribution; and a primary particle size is 67.1-70.2 mu m. The product purity reaches more than 99.5%, and a single molar yield during the crystallizing process is more than 98.0%; and the method is simple in process, low in cost and suitable for industrial production.

Description

technical field [0001] The invention belongs to the technical field of crystallization, and in particular relates to a method for preparing crystallization of creatine phosphate sodium. The method of the invention can obtain high-purity creatine phosphate sodium. Background technique [0002] Phosphatee creatine sodium (Phosphatee creatine sodium) is the disodium salt of creatine phosphate, the chemical name is N-[imino (phosphine amino) methyl]-N-methylglycine disodium salt, and the molecular formula is C 4 h 8 N 3 o 5 Na 2 P, the molecular weight is 255.08, and its chemical structure is shown below. [0003] [0004] Creatine phosphate sodium is an effective clinical drug for the human body to supplement the high-energy compound creatine phosphate. Creatine phosphate has more energy than an equivalent amount of adenosine triphosphate (ATP). It was discovered by American scientist Eggleton in 1927 Isolated from mammalian muscle. Phosphocreatine plays an important r...

AI Technical Summary

Problems solved by technology

There is the problem of product separation and purification in the method for producing creatine phosphate sodium by these methods, and the purification method of creatine phosphate sodium reported in CN101033237A needs to introduce anion exchange resin, and the cost and regeneration cost of resin are relatively high, and maintenance is quite time-consuming , is unfavorable for industrialized production; in the refining method of creatine phosphate sodium reported in CN101812088A, a chromatographic column needs to be used for separation and purification, and the cost of equipment and later maintenance is relatively high, which is unfavorable for large-scale production and use

The process for the crystallization and purification of creatine phosphate sodium reported in CN102558227A is relatively loaded down with trivial details, needs to introduce a large amount of sodium hydroxide and glacial acetic acid, and the production cost is relatively high, and content reaches 99.5% after crystallization and purification of creatine phosphate sodium, but the single pass yield is lower than 93% %

In CN102633833A, crystallization method is used to purify the crude product of creatine phosphate sodium, but it is not suitable for high-concentration sodium creatine phosphate aqueous solution. Although the product purity is above 99.7%, the yield of the crystallization process is only 89% low, and there is no crystal habit for crystal products. , granularity research

CN102533880A The product yield of sodium creatine phosphate obtained by bioengineering method is more than 70%, the yield is relatively low, and the production cost is relatively high

[0006] Domestic creatine phosphate sodium products have problems such as small particle size and poor crystal habit. The main particle size is about 35 μm. There is serious hardening phenomenon in the production process, and the operation is very difficult.

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