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Sterile bovine colostrum whey with natural immunocompetence and preparation method and application thereof

A technology of natural immunity and colostrum, applied in whey, application, dairy products, etc., can solve the problems of immunoglobulin retention, product irritating odor, whey membrane flux attenuation, etc., and achieve high immunoglobulin content , maintain natural activity, slow flux decay effect

Active Publication Date: 2015-05-27
HEILONGJIANG KANPURE BIOTECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

2. Although radiation sterilization can denature bacterial proteins, it will also cause denaturation of some immunoglobulins in bovine colostrum. This method will also cause the product to produce a pungent odor
3. Although ultra-high pressure sterilization technology can retain the activity of functional components, it has no obvious effect on killing bacterial spores, and it is difficult to make the product reach a sterile state
4. Directly use ceramic membrane and other microfiltration equipment to sterilize. Impurities such as residual fat and casein particles in bovine colostrum whey will easily block the membrane pores, so the pore size will be further reduced, resulting in the retention of immunoglobulins. Membrane flux will decay quickly, which is not conducive to industrial production
There are great differences in the processing technology of bovine colostrum between domestic and foreign enterprises, but few enterprises can break through the technical barriers of colostrum whey protein loss caused by heat sterilization and membrane technology, and form an industrial scale

Method used

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  • Sterile bovine colostrum whey with natural immunocompetence and preparation method and application thereof
  • Sterile bovine colostrum whey with natural immunocompetence and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] Place 6L of bovine colostrum in a preparative centrifuge at 45°C and centrifuge at 4000r / min for 20min to remove fat to obtain 5L of defatted bovine colostrum. Use the rennet method to precipitate the casein in the skim colostrum, that is, heat the skim colostrum to 40°C, add rennet in the proportion of 0.02% of the weight of the skim milk, stir evenly, and let the casein coagulate. The coagulated casein is cut into 1-2cm blocks, the whey crude extract is filtered out, and centrifuged at 4000r / min for 20min to obtain the whey liquid. A 0.4μm hollow fiber membrane is used for pre-filtration to remove impurities such as fat, casein, and most bacteria in the whey, so that the active ingredients can penetrate and obtain a clear whey liquid. The inlet pressure is 1.0bar and the outlet pressure is 0.1 bar, temperature 20°C. Filter and sterilize through a 0.1 μm polytetrafluoroethylene membrane filter. Filled under aseptic conditions, it becomes aseptic bovine colostrum whey...

Embodiment 2

[0025] Place 6L of bovine colostrum in a preparative centrifuge at 45°C and centrifuge at 4000r / min for 20min to remove fat to obtain 5L of defatted bovine colostrum. Precipitate casein in defatted bovine colostrum by isoelectric point method, that is, adjust the pH of defatted bovine colostrum to 4.3 with 1M lactic acid, and let it stand at 40°C for 20 minutes. After casein precipitation is complete, centrifuge to obtain whey liquid. A 1.2μm hollow fiber membrane is used for pre-filtration to remove impurities such as fat, casein, and most bacteria in the whey, so that the active ingredients can penetrate and obtain a clear whey liquid. The inlet pressure is 1.0bar and the outlet pressure is 0.1 bar, temperature 20°C. Filter and sterilize through a 0.4 μm polytetrafluoroethylene membrane filter. Filled under aseptic conditions, it becomes aseptic bovine colostrum whey liquid. The whey liquid is added to milk to obtain a drink with the function of enhancing immunity, wherein...

Embodiment 3

[0027] Dissolve bovine colostrum whey powder with purified water at 30°C at a concentration of 7%, and stir for 30 minutes to obtain whey liquid. 1.0μm ceramic membrane is used for pre-filtration, the inlet pressure is 0.8bar, and the outlet pressure is 0.4bar. Filter and sterilize through a 0.3 μm polytetrafluoroethylene membrane filter. Filled under aseptic conditions, it becomes aseptic bovine colostrum whey liquid. The whey liquid is added to the fruit juice to obtain a drink with the function of enhancing immunity, wherein the added mass fraction of the whey liquid is 20%.

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Abstract

The invention relates to sterile bovine colostrum whey with natural immunocompetence, and a preparation method and an application thereof. The preparation method comprises the steps of centrifuging bovine colostrum, removing fat to obtain defatted bovine colostrum, settling casein in the defatted bovine colostrum by an isoelectric point method or a chymosin method, obtaining whey liquid, or dissolving bovine colostrum whey powder to obtain the whey liquid, pre-filtering with a hollow fiber membrane or a ceramic membrane, removing the residual fat, casein and most thalli in the whey, conducting filtration sterilization with a polytetrafluoroethylene membrane filter, filling under a sterile condition, and obtaining the sterile bovine colostrum whey. The sterile bovine colostrum whey is degermed by a polytetrafluoroethylene degerming membrane based on pre-filtering, the handling capacity of feed liquid is increased, the service life of the membrane is prolonged, the membrane cost is saved, and the sterile bovine colostrum whey is suitable for industrial production. The content of immunoglobulin in the obtained whey is high; sterile requirements can be met; and the whey can directly serve as an immunoglobulin-rich whey product, and can also be added to beverages such as milk and fruit juice to be made into functional beverages.

Description

technical field [0001] The invention relates to a bovine colostrum whey and a preparation method thereof, in particular to an aseptic bovine colostrum whey with natural immune activity, a preparation method thereof and an application in preparing a functional drink. Background technique [0002] Bovine colostrum whey is rich in nutrients, immune factors and growth factors, such as immunoglobulin, lactoferrin and proline-rich polypeptide, etc., which have the functions of immune regulation, improving gastrointestinal tract and regulating gastrointestinal flora, etc. effect. The following factors should be considered in the production of whey products: 1. Due to the poor heat resistance of the active protein in bovine colostrum, it is not suitable to adopt the heat treatment process of normal milk, otherwise the denatured protein will coke in the heating equipment, resulting in Contamination of subsequent production. Immunoglobulins such as sIgA, IgM, IgG, etc. are macromole...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A23C21/00A23C21/06A23C21/08
Inventor 赵红宇周盛华李学琳朱洪艳
Owner HEILONGJIANG KANPURE BIOTECH
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