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Composite material for making degradable ureteral stent and degradable ureteral stent

A technology of ureteral stents and composite materials, which is applied in the field of composite materials for degradable ureteral stents, can solve the problems of low molecular weight, slow degradation of composite materials, and poor elasticity, so as to reduce pain and burden, prevent ureteral stenosis, and improve the surface performance effect

Active Publication Date: 2014-11-05
ZHEJIANG APELOA JIAYUAN BIOMEDICAL MATERIAL +2
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Foreign existing literature reports (Laaksovirta, S Laurila M.et al.Jurol, 167:1527, 2002) adopts degradable lactide-glycolide copolymer (PLGA) to make ureteral stent tube for original composite material, this The disadvantage of the ureteral stent is that the molecular weight is too low, the degradation time is too fast, and the supporting effect can only last for about a week, and the composite material is a typical plastic body, which is relatively hard and has poor elasticity
[0005] Chinese patent application CN101212937A discloses a fiber-reinforced composite absorbable ureteral stent. The absorbable composite material in this patent application can be made of L-lactide / ε-caprolactone. When implanted, the ureteral stent and ureter High wall friction makes implantation difficult, and the composite material degrades too slowly during indwelling in the body, and debris formed during the degradation process may block the ureter

Method used

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  • Composite material for making degradable ureteral stent and degradable ureteral stent
  • Composite material for making degradable ureteral stent and degradable ureteral stent
  • Composite material for making degradable ureteral stent and degradable ureteral stent

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] Put 180 grams of ε-caprolactone monomer and 320 grams of L-lactide that were dehydrated and purified into a 2500ml reaction bottle, then add 0.01% stannous octoate catalyst, and react under vacuum conditions at 150°C for 8 hours , to obtain an elastic copolymer, the copolymer was dissolved in acetone, precipitated with ethanol, and the precipitate was dried in a vacuum dryer for 48 hours to obtain the L-lactide / ε-caprolactone copolymer elastomer composite material. The molecular weight of the product is determined by gel permeation chromatography (GPC), and the weight average molecular weight is 380,000. According to the NMR 1H spectrum, the molar ratio of L-lactide and ε-caprolactone structural units in the polymer is 75:25 , the glass transition temperature (Tg) of L-lactide / ε-caprolactone copolymer was determined to be 0.67°C by differential scanning calorimetry.

[0028] 10 grams of cross-linked polyvinylpyrrolidone (particle size 5 ~ 50μm, commercial brand: PolyKoV...

Embodiment 2

[0030]Put 150 grams of ε-caprolactone monomer and 350 grams of L-lactide that were dehydrated and purified into a 2500ml reaction bottle, then add 0.01% stannous octoate catalyst, and react under vacuum conditions at 150°C for 6 hours to obtain Elastic copolymer, the copolymer is dissolved in acetone, precipitated with ethanol, and the precipitate is dried in a vacuum dryer for 48 hours to obtain the L-lactide / ε-caprolactone copolymer elastomer composite material. The molecular weight of the product is determined by gel permeation chromatography (GPC), and the weight average molecular weight is 455,000. According to the NMR 1H spectrum, the molar ratio of L-lactide and ε-caprolactone structural units in the polymer is 80:20 , the glass transition temperature (Tg) of L-lactide / ε-caprolactone copolymer was determined to be 7°C by differential scanning calorimetry. Using a melt blending method, using a twin-screw extruder, under the condition of 155 ° C, prepare L-lactide / ε-capro...

Embodiment 3

[0033] Put 200 grams of ε-caprolactone monomer and 350 grams of L-lactide that were dehydrated and purified into a 2500ml reaction bottle, then add 0.01% stannous octoate catalyst, and react under vacuum conditions at 150°C for 8 hours to obtain Elastic copolymer, the copolymer is dissolved in acetone, precipitated with ethanol, and the precipitate is dried in a vacuum dryer for 48 hours to obtain the L-lactide / E-caprolactone copolymer elastomer composite material. The molecular weight of the product was determined by gel permeation chromatography (GPC) to have a weight average molecular weight of 330,000, and as determined by nuclear magnetic 1H spectrum, the molar ratio of L-lactide and ε-caprolactone structural units in the polymer was 73:27 , The glass transition temperature (Tg) of the L-lactide / E-caprolactone copolymer was determined to be -1°C by differential scanning calorimetry. With the method of solution blending, with reference to the steps of Example 1, prepare L-...

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Abstract

The invention provides a kind of composite material for making a degradable ureteral stent, comprising: 60-98% by weight of L-lactide / Epsilon-caprolactone copolymer, and 2-40% by weight of polyvinylpolypyrrolidone. The L-lactide / Epsilon-caprolactone copolymer in the composite material is elastomeric material with good biocompatibility, and the polyvinylpolypyrrolidone can reduce a surface friction coefficient of the prepared degradable ureteral stent, and simultaneously raises the degradation speed of the degradable ureteral stent. The invention also discloses a degradable ureteral stent prepared by the composite material. The degradable ureteral stent has good biocompatibility, is easy to degrade, and can be used in an operation in urinary surgery.

Description

technical field [0001] The invention belongs to the field of biomedical materials, and in particular relates to a composite material used for a degradable ureteral stent and an application thereof. Background technique [0002] Ureteral stent (double pigtail catheter, or D-J tube) is widely used in urological surgery. It is suitable for upper urinary tract surgery, lithotripsy, and dilation of ureteral stenosis. After it is implanted in the ureter, it can It plays an important role in draining urine and preventing ureteral stricture and adhesion blockage. At present, most of the ureteral stents in clinical use are made of silicone rubber or polyurethane polymer composite materials that cannot be degraded in the human body, and there are some insurmountable defects in clinical application, such as: they must be removed through invasive operations, that is, through cystoscopy. Although this type of cystoscopic operation is not considered a major operation, the patient will su...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L31/06A61L31/04A61L31/18A61F2/82
Inventor 陈和春张大宏熊成东庞秀炳陈栋梁
Owner ZHEJIANG APELOA JIAYUAN BIOMEDICAL MATERIAL
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