Method for preparing Ag-Ti-O antibacterial nanotube film on surface of titanium alloy

Abstract

The invention provides a method for preparing an Ag-Ti-O antibacterial nanotube film on the surface of a titanium alloy, and belongs to the technical field of nanotube film preparation. The method is characterized by including placing a preprocessed test piece on a sample stage of pulse DC magneto-controlled sputter coating equipment, and placing a plane TiAg alloy target opposite to the sample; feeding argon into a vacuum chamber, and sputter-cleaning the vacuum chamber and the preprocessed test piece; coating a TiAg alloy film layer on the surface of the test piece after the cleaning; and then performing anodic oxidation treatment on the alloy film layer to prepare the Ag-Ti-O nanotube film. The film prepared through the method is good in film-substrate cohesion, and has a long-acting antibacterial property and excellent biocompatibility.

Description

technical field [0001] The invention belongs to the field of nanotube film material preparation, and relates to a method for preparing Ag-Ti-O nanotube film with long-term antibacterial ability and excellent biocompatibility on the surface of titanium alloy. Background technique [0002] Due to its excellent mechanical properties and biocompatibility, titanium alloys have been widely used as implant materials, such as artificial joints, dental implants, orthodontic wires, etc. However, the high incidence of postoperative infection associated with titanium alloys has caused great harm to the recovery of patients, such as increasing medical expenses, prolonging recovery time, and leading to various complications and even death. [0003] In order to solve the above problems, the commonly used method at home and abroad is to modify the surface of titanium alloy. The commonly used methods are: (1) ion implantation method, (2) antibacterial drug loading method, etc. The ion impla...

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Problems solved by technology

The ion implantation method is to dope some elements with antibacterial properties on the surface of the material, such as Ag, Cu, Zn, etc., which can significantly enhance the antibacterial properties of the material and reduce the probability of infection. However, the thickness of the reaction layer of this process is limited. The maximum is only 200nm, the dose of doping elements is very limited, the effective antibacterial dose precipitated in the organism is far from meeting the requirements of killing all bacteria, and does not have a long-term bactericidal effect, and the ion implantation method equipment is expensive and the process cost is very high The antibacterial drug loading method is generally through the impregnation method, freeze-drying method and photoreduction method. It is to load gentamicin and other antibacterial drugs on the surface of the material to achieve antibacterial purposes.

This process method can obtain stronger antibacterial effect than ion implantation, but the loaded antibacterial drugs are all physically adsorbed on the surface of the material, which can fully meet the antibacterial requirements in a short period of time after implantation in the organism, but with the implantation time Prolonged, the dose of its precipitation drops rapidly, making the long-acting antibacterial effect not good, and causing bacteria to develop drug resistance

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