Pharmaceutical composition for treating eye diseases and preparation method

A composition and drug technology, applied in the field of pharmaceutical composition and its preparation, can solve problems such as toxic and side effects, achieve the effects of improving visual function, reducing recurrence rate, and reducing adverse reactions

Active Publication Date: 2013-05-01
山东施尔明眼科医院
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] However, with the wide application in clinic, its adverse reactions or side effects are also widely concerned by the people.

Method used

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  • Pharmaceutical composition for treating eye diseases and preparation method
  • Pharmaceutical composition for treating eye diseases and preparation method
  • Pharmaceutical composition for treating eye diseases and preparation method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] 1. Extraction:

[0028] (1) Extraction of Gardenia: 100g of Gardenia plus 8 times the amount of 50% ethanol to extract twice, the first time is 1.5 hours, the second time is 1 hour, the decoction is combined, filtered, concentrated to 1.15-1.20 (50°C ) clear paste, dried under reduced pressure to obtain 26g dry paste, i.e. gardenia extract.

[0029] Take 10g of gardenia dry paste, add 20ml of water to dissolve it ultrasonically, extract with petroleum ether, ethyl acetate, and n-butanol in sequence, concentrate under reduced pressure to recover the solvent, and finally dry under reduced pressure to obtain 3.2g of n-butanol extract.

[0030] Determination of the partition coefficient of the sample in different solvent systems by high performance liquid chromatography, the solvent system used is n-hexane-ethyl acetate-methanol-water (1:1:1:1, 5:5:7:3, 9: 4:5:5, 3:7:5:5, 10:20:10:10, 10:25:10:5), chloroform-methanol-water (1:1:1, :4:2:1) , ethyl acetate-methanol-water (5...

preparation example 1

[0036] Cholic acid 1.0g, baicalin 3.0g, tripterygium glycosides 1.5g, carbomer 10.0g, gardenia extract 2.5g, buffalo horn extract 2.0g.

[0037] Add the aqueous solution of baicalin, tripterygium glycosides, gardenia extract, and buffalo horn extract to 70% ethanol solution of bile acid, mix well, add ethanol to make the alcohol content reach 70%, and adjust the pH value to 7.2 , stand still, recover ethanol, and obtain a spare solution. Weigh 10.0g of carbomer and add a small amount of pure water or water for injection to moisten (at least 12 hours), adjust the pH to neutral, and make the matrix form a viscous and uniform gel matrix. Add the above spare solution into the gel matrix, stir, add sodium chloride or potassium chloride, ethyl p-hydroxybenzoate, add purified water or water for injection to 1000g, mix well, sterilize, and pack into eyes Use gel.

[0038] The obtained gel is yellow and translucent, with a pH value of 7.1, an osmotic pressure of 308 mosmol, and a vis...

preparation example 2

[0040] Cholic acid 1.0g, baicalin 2.0g, tripterygium glycosides 0.5g, gardenia extract 4.5g, buffalo horn extract 2.0g, carbomer 4.0g, hypromellose 10.0g.

[0041] Add the aqueous solution of baicalin, tripterygium glycosides, gardenia extract, buffalo horn extract to 70% ethanol solution of cholic acid, mix well, add ethanol to make the alcohol content reach 70%, adjust the pH value, statically Place, reclaim ethanol, obtain reserve solution. Under aseptic operation conditions, weigh 5.0 g of hypromellose and 4.0 g of carbomer, first moisten with a solvent, and after the matrix is ​​fully moistened, stir well to form a gel matrix 1. Under sterile conditions, weigh 5.0g of hypromellose, add 10% to 20% of glycerin, grind evenly, let stand for 30 minutes, add solvent to moisten and expand, and stir well to form a gel matrix. 2. Add the above spare solution to the mixed solution of gel matrix 1 and gel matrix 2, stir, add a small amount of antibacterial agent, add purified wate...

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Abstract

The invention relates to a pharmaceutical composition and a preparation method. The pharmaceutical composition comprises the following raw materials by weight: 1-4 parts of cholic acid, 1-4 parts of scutelloside, 0.5-2 parts of tripterygium glycosides, 2-7 parts of cape jasmine and 0.5-5 parts of cornu bubali, and the raw materials are cooperated with other auxiliary materials to prepare a medicine. The pharmaceutical composition has the advantages that the pharmaceutical composition has same curative effect with a Qingkailing compound for preventing and treating uveitis, intraocular inflammation and immunological eye diseases, The pharmaceutical composition takes a holism concept of a traditional Chinese medicine as a base, by adjusting the equilibrium between yin and yang of human body, the pharmaceutical composition can reach the effects for resisting inflammation, increasing immunity, reducing recurrence rate, increasing cure rate and improving the vision function of patients.

Description

technical field [0001] The invention relates to a pharmaceutical composition and a preparation method thereof. Background technique [0002] Qingkailing injection is a traditional Chinese medicine compound preparation developed on the basis of the ancient famous prescription "Angong Niuhuang Pill". Tablets, oral liquids, etc. The main ingredients are cholic acid, mother-of-pearl powder, hyodeoxycholic acid, gardenia, buffalo horn powder, isatidis, baicalin, and honeysuckle. Its functions and indications are heat-clearing and toxic substances removing, reducing phlegm and dredging collaterals, refreshing the mind and resuscitating the mind. For fever, coma, stroke hemiplegia, unconsciousness patients, such as acute hepatitis, upper respiratory tract infection, pneumonia, cerebral thrombosis, cerebral hemorrhage see the above syndromes. Modern pharmacological studies have proved that the main active ingredients of Qingkailing injection are geniposide, baicalin, hyocholic aci...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/744A61P27/02A61K31/575A61K31/7048A61K35/32
Inventor 毕宏生解孝锋郭俊国
Owner 山东施尔明眼科医院
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