Graphene oxide surface-enhanced Raman scattering positioning drug carrier and preparation method thereof

A surface-enhanced Raman and graphene technology, which is applied in the fields of nanomaterials and bioanalytical chemistry, can solve the problems of further improvement of sensitivity, stability and biocompatibility, complicated preparation methods, etc., and achieves simple structure and drug loading capacity. High and efficient effect

Inactive Publication Date: 2013-05-01
SOUTHEAST UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although there have been a lot of reports on the structure and preparation methods of SERS probes, there are not many probes suitable for living organisms, and the preparation methods are relatively cumbersome, and the sensitivity, stability and biocompatibility need to be further improved.

Method used

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  • Graphene oxide surface-enhanced Raman scattering positioning drug carrier and preparation method thereof
  • Graphene oxide surface-enhanced Raman scattering positioning drug carrier and preparation method thereof
  • Graphene oxide surface-enhanced Raman scattering positioning drug carrier and preparation method thereof

Examples

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Embodiment 1

[0026] Example 1 uses the graphene oxide-gold nanorod composite structure as the carrier, 5,5 dithiobis(2-nitrobenzoic acid) (DTNB) as the SERS marker, and doxorubicin hydrochloride (DOX) as the drug molecule; In Example 2, the composite structure of graphene oxide-gold nanorods was used as a carrier, and 5,5 dithiobis(2-nitrobenzoic acid) (DTNB) was used as a SERS marker, and 9-aminoacridine hydrochloride ( 9AA) is illustrated as a drug molecule as an example.

[0027] Example 1

[0028] The composite structure of graphene oxide-gold nanorods was used as a drug carrier, 5,5 dithiobis(2-nitrobenzoic acid) (DTNB) was used as a SERS marker, and doxorubicin hydrochloride (DOX) was used as a drug molecule. The method includes the following steps:

[0029] 1) Prepare a solution of polymer-modified gold nanorods and label Raman molecules. To prepare gold seeds first, mix 2.5 ml of 0.2 M cetyltrimethylammonium bromide (CTAB) solution with 1.5 ml of 1.0 mM tetrachloroauric acid sol...

Embodiment 2

[0037] The composite structure of graphene oxide-gold nanorods was used as a drug carrier, 5,5-dithiobis(2-nitrobenzoic acid) (DTNB) was used as a SERS marker, and 9-aminoacridine hydrochloride (9AA) was used as a drug carrier. Drug molecules, the method comprises the steps of:

[0038] 1) Prepare a solution of polymer-modified gold nanorods and label Raman molecules. To prepare gold seeds first, mix 2.5 ml of 0.2 M cetyltrimethylammonium bromide (CTAB) solution with 1.5 ml of 1.0 mM tetrachloroauric acid solution at room temperature, stir vigorously and add 0.6 ml of ice-cold 0.01 M hydroboration Sodium solution, stop stirring after 2 minutes to obtain a brown-yellow seed solution. Then prepare the growth solution, add the following reagents in sequence in 50ml0.2M CTAB solution at room temperature: 2~4ml4mM silver nitrate solution, 5ml15mM tetrachloroauric acid solution, 45ml deionized water, and stir slowly evenly. Then add 1.5ml~3ml0.08M ascorbic acid until the solution be...

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Abstract

The invention relates to a graphene oxide surface-enhanced Raman scattering positioning drug carrier and a preparation method thereof and one or more drugs carried by the graphene oxide surface-enhanced Raman scattering positioning drug carrier. The graphene oxide surface-enhanced Raman scattering positioning drug carrier utilizes a composite structure of graphene oxide and metal nanoparticles to carry a drug, utilizes surface-enhanced Raman scattering signals to trace a carrier position, and has a high drug carrying amount. A positively charged polymer modifies the surface of graphene oxide. The metal nanoparticles are gold nanorods. Raman molecules are adsorbed on the metal nanoparticles. The graphene oxide surface-enhanced Raman scattering positioning drug carrier solves the problem that the existing nano-drug carrier has a complex structure, a high synthesis cost and low efficiency and is difficult to industrialize. The preparation method comprises the following steps of graphene oxide preparation, graphene oxide-metal nanoparticle compound preparation, and graphene oxide drug carrier material preparation. The one or more carried drugs are selected from doxorubicin hydrochloride, 9-aminoacridine hydrochloride and hydroxycamptothecin.

Description

technical field [0001] The invention relates to the fields of nanomaterials and bioanalytical chemistry, in particular to a preparation method of a graphene oxide-based magnetic targeting drug carrier and loaded drugs. The carrier has excellent targeting performance and drug loading capacity. The preparation method is simple in operation, good in repeatability, low in cost and friendly to the environment. Background technique [0002] As an optical detection technology emerging in recent years, surface-enhanced Raman scattering (SERS) technology has gained rapid development in just a few years after its birth due to the combination of the advantages of traditional Raman scattering and plasmon wave enhancement. develop. SERS breaks through the bottleneck caused by the low scattering cross section of traditional Raman scattering, avoids the problems of photobleaching and the toxicity of fluorescent labels in fluorescence spectral imaging, and is currently the research focus o...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K47/02A61K47/04A61K47/32A61P35/00
Inventor 王著元崔一平陈辉宗慎飞
Owner SOUTHEAST UNIV
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