Method for purifying gastrodigenin

Abstract

The invention discloses a method for purifying gastrodigenin, which comprises the following steps: a raw material is put into a feed hopper after coarse grinding, a host machine of an extraction tank unit rotates to slowly push forward the material from the front end of the unit to the back end, and meanwhile, an extraction solvent enters into the extraction tank from a liquid inlet tube at the tail end of the unit, passes through the moving material from the rear-end of the tank and flows to the front end thereof. In this way, the solid material and the liquid material are contacted fully in the inverse motion, and the effective constituent in the medicinal material is extracted. The herb residue is forcibly pushed forward by a discharging conveyer to a taphole and discharged, and a special juicer extrudes the residual soup of the herb residue out of the medicinal material to reduce the content of the residual soup in the herb residue. The extraction efficiency is higher and the extraction is safer. The method disclosed by the invention selects both extraction of a continuous extraction tank unit and purification of column chromatography on silica gel, so the separation effect is better, and the finished gastrodigenin with the highest yield of 0.2% and content of greater than 95% can be obtained.

Description

Technical field: [0001] The invention belongs to the field of natural organic chemistry and relates to a method for purifying gastrodin aglycone, in particular to a method for purifying gastrodin aglycone by using macroporous adsorption resin coupled with silica gel column chromatography. Background technique: [0002] Gastrodia elata is the dry tuber of the orchid plant Gastrodia elata Bl. Also known as Chijian, Limu, Guiduyou, Shencao, Duyaozhi, Chijianzhi, Dingfengcao, Helicao, Duyao, Automatic Grass, and Water Potato. Contains gastrodin, gastrodin, vanillin, protein, amino acid, trace elements. Have anti-epileptic, anti-palpitation, anti-rheumatism; Sedative, antispasmodic, analgesic, invigorating deficiency, calming liver and calming wind. Functions and indications Calming liver, calming wind and relieving spasm. For headache dizziness, limb numbness, epileptic convulsions, tetanus. Dizziness, neurasthenia, anemofrigid-damp arthralgia, convulsions in children and ot...

AI Technical Summary

Problems solved by technology

The extraction process of gastrodin aglycone in the above patent documents is mainly refined through pretreatment, enzymatic hydrolysis, supercritical extraction, methanol recrystallization and other steps. Although the final gastrodin aglycone has a high purity, the process itself is expensive and practical The application effect is far inferior to the purification and separation effect of macroporous adsorption resin coupled with silica gel column chromatography