POSS/poly lactic acid and poly(n-isopropyl acrylamide) star block copolymer preparation

A technology of block copolymers and polylactic acid, which is applied in the direction of non-active ingredient medical preparations, medical preparations containing active ingredients, emulsion delivery, etc., can solve the problem of dissociation of micelles, irregular micellar structure, Changeable shape and other problems, to achieve the effect of controllable size, stable product structure and regular shape

Inactive Publication Date: 2013-05-08
NANTONG ZHENGDA AGROCHEM
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Most of the currently reported nanomicelles are formed by the self-assembly of block linear copolymers or graft copolymers in water, and the polymer molecules are aggregated by the interaction of hydrophobic segments, so such nanomicelles Bundles are not stable enough as drug controlled release carriers
When the micelle concentration is diluted below the critical micelle concentration in the blood, or when the micelle inter

Method used

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  • POSS/poly lactic acid and poly(n-isopropyl acrylamide) star block copolymer preparation
  • POSS/poly lactic acid and poly(n-isopropyl acrylamide) star block copolymer preparation
  • POSS/poly lactic acid and poly(n-isopropyl acrylamide) star block copolymer preparation

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] Embodiment 1 Alkali-catalyzed synthesis of primary amino cage silsesquioxane:

[0024] Add 23 mL of deionized water, 13 mL of propanol, 3 mL of acetonitrile and 0.5 mL of tetraethylammonium hydroxide aqueous solution into a 100 mL flask and mix, and mix 55 g of γ-aminopropyltriethoxysilane under vigorous stirring in Add to the reaction system within 10 minutes, heat the solution to 55°C under vigorous stirring, stop after 20 hours of reaction, add about 2 times the volume of tetrahydrofuran to the reaction solution, a white precipitate is formed, collect the white precipitate, and dry .

Embodiment 2

[0025] Embodiment 2POSS-(NH 2 ) 8 Initiate the living ring-opening polymerization of D,L-lactide:

[0026] Weigh POSS-(NH 2 ) 8 1.762 grams (0.002mol), D, L-lactide 11.52 grams (0.080mol), placed in a 50ml single-necked flask, vacuum-filled with nitrogen for three times, stirred and melted in an oil bath at 135°C for 5min, then added D with a syringe , 0.5% stannous octoate-toluene solution of L-lactide quality, then vacuum-filled nitrogen cycle three times, reacted at 135 ° C for 24 hours. Natural cooling after stopping the reaction, the product was dissolved with 5 mL of dichloromethane, and then A large amount of n-hexane precipitated and repeated three times to obtain a light yellow liquid, which was vacuum-dried to obtain POSS-PLA-1, a star-shaped polymer with regular structure.

Embodiment 3

[0028] Weigh POSS-(NH 2 ) 8 1.762 grams (0.002mol), D, 23.04 grams (0.16mol) of L-lactide, other materials and operation methods are reacted as embodiment 2, obtain POSS-PLA-2

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Abstract

According to the present invention, cage octa-aminopropyl silsesquioxane (POSS-NH2) is adopted as a starting molecule, an initiation effect of the surface amino in the POSS-NH2 is adopted to make the POSS containing a plurality of amino initiate active loop opening polymerization of D,L-lactide under catalysis of stannous octanoate to obtain a star polymer POSS-PLA having structural regularity, the terminal hydroxyl group of the star polymer is converted into a macromolecule initiator capable of initiating atom transfer radical polymerization (ATRP) to carry out an ATRP reaction of N-isopropyl acrylamide (NIPAAm) to synthesize a star block copolymer adopting the POSS as a center, adopting poly lactic acid as a core, and adopting poly(N-isopropyl acrylamide) as a shell, the star block copolymer is dissolved in DMF, the obtained solution is added to water in a dropwise manner to prepare micelles, a scanning electron microscopy (SEM) is adopted to observe a shape and a size of the micelle, and dynamic light scattering (DLS) is adopted to determine a particle size and distribution of the micelles and confirm structural regularity of the micelles, wherein a diameter of the micelles is about 170 nm, and the nanometer micelles have functions of drug loading and temperature control release.

Description

technical field [0001] The preparation of an inorganic / polymer star-shaped block copolymer involves step-by-step living polymerization of lactide and N-isopropylacrylamide with an inorganic nanoparticle as the central molecule to obtain a core-shell The invention relates to a star-shaped block copolymer of structure, which belongs to the technical field of functional materials. Background technique [0002] In recent years, people have paid great attention to the technology of using polymer nanomaterials as drug carriers. It is hoped that this technology can bring new insights into the treatment of some major human diseases such as cancer, cardiovascular diseases, infectious diseases and neurological diseases. Breakthrough. Preparation and research of nano-micelle with novel structure and excellent performance, and using it as a carrier for controlled drug release, which is of great significance for the development of new medical materials and the improvement of human health...

Claims

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Application Information

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IPC IPC(8): C08F293/00C08G63/91C08G63/695C08G63/08A61K47/34A61K31/192A61K9/10
Inventor 倪才华王艳张丽萍
Owner NANTONG ZHENGDA AGROCHEM
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