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Sensitive glow discharge direct ionization method and device thereof

A technology of glow discharge and ionization, which is used in measurement devices, plasmas, ion sources/guns, etc., can solve problems such as large size of the device, and achieve the effects of small size, simple operation and low power.

Inactive Publication Date: 2013-05-08
INST OF CHEM CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Compared with the DAPCI source, the integrated DART source has only one moving part, which improves flexibility, but at the same time makes the device larger, and still requires a carrier gas flow rate of at least 1L / min

Method used

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  • Sensitive glow discharge direct ionization method and device thereof
  • Sensitive glow discharge direct ionization method and device thereof
  • Sensitive glow discharge direct ionization method and device thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] Embodiment 1, sensitive glow discharge direct ionization device

[0035] The glow discharge direct ionization device (i.e. the needle-sleeve device) of the present embodiment comprises a stainless steel cone sleeve electrode 1 with a polytetrafluoroethylene insulating gasket 2 and a polytetrafluoroethylene three-way tungsten needle electrode 5- 7. The shape of the drogue electrode 1 is a cylinder, one end of which is inserted on the ion transfer tube 3 of the mass spectrometer, and a sealed insulating gasket 2 is arranged between the drogue electrode and the ion transfer tube; the drogue electrode 1 The other end of the cylinder is bell-shaped, that is, the inside of the cylinder is a hollow cone, and the inner diameter of the outer cone is 9.0mm. The cone sleeve electrode 1 is provided with a connecting rod 4 to be grounded; the needle electrode 5 is connected to a DC power supply and runs through the polytetrafluoroethylene Tonghe stainless steel thin tube 7; the inn...

Embodiment 2

[0037] Embodiment 2, Clenbuterol (Clenbuterol) compares the chromatogram and mass spectrum on the new ionization source provided by the present invention and the conventional needle plate discharge source

[0038] Using the glow discharge direct ionization device in Example 1 to generate plasma, desorb and ionize the β-agonist drug clenbuterol (commonly known as clenbuterol), and perform mass spectrometry detection.

[0039] The specific method is as follows: Utilize the glow discharge direct ionization device of embodiment 1 to generate plasma, wherein, the needle electrode 5 is connected to a 2.2kV DC power supply, the flow rate of the carrier gas (argon) is 300mL / min, and the needle electrode 5 is aligned with the cone The sheath electrode 1 is discharged, and the distance between the tip of the needle electrode 5 and the drogue sheath electrode 1 is 4mm; the included angle between the needle electrode 5 and the central axis of the drogue sheath electrode 1 is 35°. Add drop...

Embodiment 3

[0041] Embodiment 3, the mass spectrometry detection of plant sample on the new ionization source provided by the present invention

[0042] Utilize the glow discharge direct ionization device of Example 1 to generate plasma, and then perform mass spectrometry detection on the ionization source for biological samples including living plants. Specific samples include shredded tobacco a, commercially available fresh pepper b, onion c and garlic d and so on. The signature components of these samples are clearly visible in the mass spectra, mainly forming proton-added molecular ions like nicotine 163 in tobacco shreds a, capsaicin 306 in b, propanthial 91 in onions c and allicin 163 in d ; And the latter two are also easy to form +18 ammonium adduct ions.

[0043] The specific method is as follows: use the glow discharge direct ionization device of Example 1 to generate plasma, wherein the needle electrode 5 is connected to a 3kV DC power supply, the flow rate of the carrier gas ...

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Abstract

The invention discloses a sensitive glow discharge direct ionization method and the sensitive glow discharge direct ionization device. The device comprises a taper sleeve electrode and a glow discharge plasma generating device which discharges to the taper sleeve electrode. A slot which is used for inserting an ion transport tube of a mass spectrometer in a sleeved mode is arranged inside one end of the taper sleeve electrode, and insulating spacers of the sealing taper sleeve electrode and the ion transport tube are arranged outside of the end port of the taper sleeve electrode. The other end of the taper sleeve electrode is in a horn-mouth-shaped hollow taper shape and is communicated with the ion transport tube. The taper sleeve electrode is provided with a junction pole for connecting the ground. The sensitive glow discharge direct ionization device comprises a closed tubular cavity and pin electrodes penetrating through the tubular cavity. The pin electrodes extend from two ends of the tubular cavity. Slim tubes are arranged at the pin electrodes arranged outside of the tubular cavity in a sleeved mode. The slim tubes and the tubular cavity are in sealing connection. A ring cavity is formed between the slim tubes and the pin electrodes. The ring cavity is communicated with an inner cavity of the tubular cavity. Carrier gas inlets are formed in a side wall of the tubular cavity. End ports of the slim tubes arranged in the pin electrodes in a sleeved mode are carrier gas outlets.

Description

technical field [0001] The invention relates to a sensitive glow discharge direct ionization method and a device thereof. Background technique [0002] Atmospheric pressure desorption ionization mass spectrometry can directly and rapidly ionize the sample under normal atmospheric pressure without pretreatment or with minimal pretreatment, so as to achieve high-throughput, high-specificity qualitative or quantitative analysis of mass spectrometry. After a lot of research in recent years, about 30 atmospheric desorption ionization techniques have been developed, which are widely used in food safety, drug analysis, environmental analysis, process analysis, biological imaging, living body analysis, metabolomics analysis, proteomics Analysis, forensic investigation, and more. The representative atmospheric pressure desorption ionization technology is mainly divided into two categories, that is, the ionization source characterized by solution electrospray, such as desorption elec...

Claims

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Application Information

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IPC IPC(8): H01J49/10H01J49/12G01N27/68H05H1/24
Inventor 聂宗秀周跃明张宁熊彩侨
Owner INST OF CHEM CHINESE ACAD OF SCI
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