Method for preparing hydrophobic medicament nuclear shell granule-type solid dispersion by static electricity spraying method

Abstract

The invention discloses a method for preparing a hydrophobic medicament nuclear shell structure micro / nano granule-type solid dispersion by a high-voltage static electricity spraying method, relating to the pharmaceutics and biomedical field. The method comprises the following steps of: dissolving hydrophobic medicaments and fat soluble high polymer materials together into an organic solvent, and emulsifying and dispersing the mixture into an aqueous solution containing water soluble high polymer material; then placing oil-in-water emulsion into a trace propeller, and carrying out electrostatic spraying under the effect of high-voltage electrostatic field, thereby obtaining the hydrophobic medicament nuclear shell structure micro / nano granule-type solid dispersion finally. According to the preparation method, the operation is simple, the cost is low, environmental protection is realized and industrial production is facilitated. The particle size of the prepared hydrophobic medicament nuclear shell structure micro / nano granule-type solid dispersion is controllable, and the solid dispersion has tissue and organ targeting; and the granules of the nuclear shell structure is beneficial to prolonging the medicament action time.

Description

technical field [0001] The invention relates to the fields of pharmacy and biomedicine, in particular to a method for preparing hydrophobic drug core-shell particle solid dispersion by electrostatic spraying. Background technique [0002] Solid dispersion refers to the highly dispersed drug in a solid carrier to form a dispersion system in solid form, which is mainly used to accelerate and increase the dissolution of insoluble drugs and improve their bioavailability. At present, the commonly used techniques for preparing drug-loaded micro / nanoparticles include melting method, solvent method, solvent-melting method, grinding method, solvent spray drying method, freeze drying method and so on. The main problems faced by the existing solid dispersion preparation technology are: (1) The stability of the prepared solid dispersion is not good, and the drug agglomeration phenomenon is serious; (2) Steps such as crushing and sieving are often required, and the process is complicated...

AI Technical Summary

Problems solved by technology

The main problems faced by the existing solid dispersion preparation technology are: (1) The stability of the prepared solid dispersion is not good, and the drug agglomeration phenomenon is serious; (2) Steps such as crushing and sieving are often required, and the process is complicated and there are many influencing factors , the resulting solid dispersion has a wide particle size distribution; (3) Some non-degradable materials, such as surfactants, are often added during the preparation process; (4) The residual organic solvent is relatively high, which is difficult to effectively remove, etc.

These problems limit the further widespread application of solid dispersions