Metformin hydrochloride gastric floating tablet and preparation method thereof

Abstract

The invention relates to a metformin hydrochloride gastric floating tablet. The metformin hydrochloride gastric floating tablet contains metformin hydrochloride, a polymer gel material, a wax material and a foaming material, wherein the polymer gel material is a mixture of water-soluble resin and lactose; the wax material is at least one of octodecyl alcohol and stearic acid; and the foaming material is a mixture of sodium bicarbonate and magnesium stearate. A preparation method comprises wet process pelletization and powder direct tabletting, wherein the wet process pelletization comprises the following steps: A1) preparing the materials; A2) mixing the materials; A3) pelletizing; and A4) tabletting; and the powder direct tabletting comprises the following steps: B1) preparing the materials; B2) mixing the materials; and B3) tabletting. Each metformin hydrochloride gastric floating tablet contains 0.25-0.75g of metformin hydrochloride. The metformin hydrochloride gastric floating tablet disclosed by the invention has the advantages that after the tablets are taken by a patient, hydrophilic gel is hydrated and expanded, a medicament is simultaneously controlled to be released slowly, the onset of action of the medicament is fast, the medicament effect is lasting and the bioavailability of the medicament is high; and the frequency of taking the tablets of the patient can be reduced, the side effects are reduced, and the incidence rate of poor reactions is also reduced.

Description

technical field [0001] The invention relates to the technical field of biomedicine, in particular to a metformin hydrochloride gastric floating tablet and a preparation method thereof. Background technique [0002] Diabetes mellitus is a group of clinical syndromes caused by the interaction of genetic and environmental factors. Absolute or relative insufficiency of insulin secretion and decreased sensitivity of target tissue cells to insulin lead to a series of metabolic disorders such as sugar, protein, fat, water and electrolytes. Clinically, hyperglycemia is the main sign, and prolonged illness can cause damage to multiple systems. [0003] Metformin hydrochloride is a biguanide drug for treating diabetes. It can improve the body's insulin sensitivity by inhibiting gluconeogenesis in the liver and promoting the uptake and utilization of glucose by peripheral insulin target tissues. It can significantly improve the patient's glucose tolerance and hyperinsulinemia. , redu...

AI Technical Summary

Problems solved by technology

[0004] The commonly used dose of metformin hydrochloride is relatively large, up to 500mg / time. Due to the short half-life of metformin hydrochloride in the body, in order to maintain the effective blood concentration, ordinary tablets are taken orally 2 to 3 times a day, 1 to 2 tablets each time, which brings great harm to patients. Bring a lot of inconvenience, and the incidence of adverse reactions is greatly increased

Images