Calcitriol tablet and preparation method thereof
A technology of calcitriol and polyethylene glycol, which is applied in the field of calcitriol tablets and its preparation, can solve the problems of low bioavailability, monotonous dosage form, sensitivity of calcitriol to light and air, etc., and achieve reduction Effect of Dosage and Bioavailability Improvement
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Embodiment 1
[0041] Embodiment 1 calcitriol tablet
[0042] The prescription for 1000 tablets is:
[0043] Calcitriol 1.5mg
[0044] Meglumine 6.0g
[0045] Macrogol 400 3.6g
[0046] Macrogol 6000 45g
[0047] Starch 210g
[0048] Sodium carboxymethyl starch 15g
[0049] Appropriate amount of pregelatinized starch
[0050] Magnesium Stearate Appropriate amount.
[0051] The preparation method is:
[0052] 1) Weigh the raw and auxiliary materials of the prescription amount, pass through 80-mesh sieve respectively;
[0053] 2) Take the sieved pregelatinized starch and add distilled water to make a binder solution;
[0054] 3) Mix the sieved calcitriol, meglumine, polyethylene glycol 400, polyethylene glycol 6000, starch and sodium carboxymethyl starch evenly in equal increments, and add the above binder solution to prepare into soft material;
[0055] 4) After granulating with a 40-mesh sieve, dry at 50°C for 30 minutes, pass through a 20-mesh sieve for granulation, add magnesium...
Embodiment 2
[0056] Example 2 Calcitriol Tablets
[0057] The prescription for 1000 tablets is:
[0058] Calcitriol 1.5mg
[0059] Meglumine 12g
[0060] Macrogol 400 5.4g
[0061] Macrogol 6000 75g
[0062] Lactose 150g
[0063] Low-substituted hydroxypropyl cellulose 30g
[0064] Proper amount of hydroxypropyl cellulose
[0065] Talc powder in moderation.
[0066] The preparation method is:
[0067] 1) Weigh the raw and auxiliary materials of the prescription amount, and pass through a 120-mesh sieve for later use;
[0068] 2) Take the sieved hydroxypropyl cellulose and add distilled water to make a binder solution;
[0069] 3) Mix the sieved calcitriol, meglumine, polyethylene glycol 400, polyethylene glycol 6000, lactose and low-substituted hydroxypropyl cellulose in equal increments, and add the above binder The solution is made into a soft material;
[0070] 4) After granulating with a 40-mesh sieve, dry at 70°C for 60 minutes, pass through a 20-mesh sieve for granulation,...
Embodiment 3
[0071] Example 3 Calcitriol Tablets
[0072] The prescription for 1000 tablets is:
[0073] Calcitriol 1.5mg
[0074] Meglumine 9.0g
[0075] Macrogol 400 4.5g
[0076] Macrogol 6000 60g
[0077] Dextrin 180g
[0078] Microcrystalline Cellulose 24.0g
[0079] Proper amount of povidone
[0080] Appropriate amount of micronized silica gel.
[0081] The preparation method is:
[0082] 1) Weigh the raw and auxiliary materials of the prescription amount, pass through a 100-mesh sieve for later use;
[0083] 2) Take the sieved povidone and add distilled water to make a binder solution;
[0084] 3) Mix the sieved calcitriol, meglumine, polyethylene glycol 400, polyethylene glycol 6000, dextrin and microcrystalline cellulose evenly in an equal increment method, and add the above binder solution to prepare into soft material;
[0085] 4) After granulating with a 40-mesh sieve, dry at 60°C for 45 minutes, pass through a 20-mesh sieve for granulation, add micropowder silica gel,...
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