Polysaccharide sulfate tablet and preparation method of polysaccharide sulfate tablet

A diester sodium alginate tablet and the technology of diester sodium alginate are applied in pharmaceutical formulas, medical preparations containing active ingredients, and the digestive system. Poor stability and other problems, to achieve the effect of rapid disintegration and dissolution, fast disintegration and dissolution, and stable quality

Active Publication Date: 2014-11-12
CP PHARMA QINGDAO CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] At present, there are mainly two types of dosage forms of sodium alginate diester: one is oral tablets and capsules, and its disadvantage is that the absorption effect is not ideal; the other is water injection and freeze-dried powder injection, which has the disadvantage of being transported. Inconvenient, long injection time (more than 4 hours for one injection), and poor patient compliance

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] The preparation of embodiment 1 sodium alginate diester tablet

[0029] components Dose 1 (mg) Dose 2 (mg) Dose 3 (mg) Sodium alginate diester 10 20 40 starch 70 140 280 Mannitol 38 76 152 Low-substituted hydroxypropyl cellulose 12 24 48 Sodium carboxymethyl starch 8 16 32 Magnesium stearate 2 4 8 Sheet weight 140 280 560

[0030] Preparation Process:

[0031] (1) Weigh the raw and auxiliary materials of the above prescription amount and pass through 80-mesh sieve respectively, mix all the raw and auxiliary materials except magnesium stearate, and perform the first dry granulation to obtain Granule A;

[0032] (2) After mixing the prepared granule A with magnesium stearate for 30 minutes, compress it into tablets to obtain tablet cores;

[0033] (3) Preparation of coating solution, Opadry Add 70% ethanol solution for preparation to obtain a coating solution;

[0034] (4) Coating, add the tabl...

Embodiment 2

[0035] The preparation of embodiment 2 sodium alginate diester tablet

[0036] components Dose 1 (mg) Dose 2 (mg) Dose 3 (mg) Sodium alginate diester 10 20 40 starch 68 136 272 β-cyclodextrin 32 64 128 Low-substituted hydroxypropyl cellulose 12 24 48 Crospovidone 13 26 52 Magnesium stearate 1 2 4 Sheet weight 136 272 544

[0037] Preparation process: with embodiment 1.

Embodiment 3

[0038] The preparation of embodiment 3 sodium alginate diester tablets

[0039] components Dose 1 (mg) Dose 2 (mg) Dose 3 (mg) Sodium alginate diester 10 20 40 starch 66 132 264 microcrystalline cellulose 74 148 296 Croscarmellose Sodium Starch 16 32 64 Crospovidone 7 14 28 sodium glutamate 2 4 8 lemon zest 3 6 12 orange flavor 3 6 12 Magnesium stearate 2 4 8 Sheet weight 183 366 672

[0040] Preparation process: with embodiment 1.

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Abstract

The invention provides a polysaccharide sulfate tablet and a preparation method of the polysaccharide sulfate tablet. The invention provides the polysaccharide sulfate tablet with high bioavailability and good stability which can solve the technical problems of unsatisfactory absorption effects of the oral polysaccharide sulfate tablets and capsules at the prior art and inconvenient carry, long injection time and poor patient compliance of hydro-acupunctures and freeze-dried injections.

Description

technical field [0001] The invention belongs to the technical field of chemical preparations, and particularly relates to a tablet for anticoagulation, lowering blood viscosity, lowering blood fat, and inhibiting the aggregation of red blood cells and platelets. Background technique [0002] Alginic Sodium Diester is a polysaccharide sulfate (PSS) marine drug. It is made from alginic acid extracted from kelp and sargassum through hydrolysis, esterification and sulfonation. It is a heparin-like drug that has the effects of anticoagulation, lowering blood viscosity, lowering blood lipids, and inhibiting the aggregation of red blood cells and platelets. It is one of the drugs commonly used to improve microcirculation in recent years. The full name of sodium alginate diester is the sodium salt of propyl alginate sulfate, which is a linear polyanion electrolyte. Sodium alginate has heparin-like physiological activity, the main effects are anticoagulation, lowering blood sugar, ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/36A61K31/737A61P9/10A61P3/06A61P9/12A61P3/10A61P13/12A61P1/16A61P43/00A61P7/02A61P27/16A61P17/10A61P25/02A61P11/00
Inventor 王明刚任莉陈阳生孙桂玉翟翠云刘晓霞
Owner CP PHARMA QINGDAO CO LTD
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