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Porous polylactic acid particles and preparation method thereof

A technology of polylactic acid microparticles and polylactic acid, which is applied in the field of preparation of porous polylactic acid microparticles, can solve the problems of a large number of porogens, inhomogeneity, and complicated preparation process, and achieve easy industrial operation, effective utilization, and simple operation process Effect

Inactive Publication Date: 2013-06-26
TORAY FIBER RES INST(CHINA) CO LTD
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] In the preparation technology of above-mentioned porous polylactic acid microparticles, the shortcoming of porogen method is the removal problem of porogen, needs to use a large amount of porogen and is difficult for complete removal for preparing porous; The shortcoming of double emulsion method is that preparation process is complicated, The technical requirements are high, and the emulsion is easily broken, which makes the final particle shape uneven
The disadvantage of the solvent-induced phase separation method is that the solvent and non-solvent of the polymer need to be used at the same time, which increases the amount of materials used, and is prone to agglomeration when the particles are formed.

Method used

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  • Porous polylactic acid particles and preparation method thereof
  • Porous polylactic acid particles and preparation method thereof
  • Porous polylactic acid particles and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0053] In the there-necked flask of 250ml, add 1.25g polylactic acid (D lactic acid mass content 4.25%, model is Ingeo TM Biopolymer 4043D), 1.25g hydroxypropyl cellulose (3~6mPa·s, 2% aqueous solution at 20°C), 22.5g diethylene glycol dimethyl ether (boiling point 162°C, 101.3kPa), heated to 80°C, And stir at a speed of 450rpm until the polymer dissolves. Then 25 g of deionized water was added dropwise to the above system at a rate of 0.42 g / min. After the dropwise addition was completed, the resulting suspension was filtered, washed with 100 g of deionized water, filtered, and the filtered product was vacuum-dried at 45° C. for 12 hours to obtain 1.15 g of white polylactic acid powder. Observation of the obtained powder with a scanning electron microscope showed a spherical porous structure ( figure 1 ), the volume average diameter is 39 μm, the particle size distribution index is 1.4, the porosity is 60%, and the oil absorption is 140mL / 100g.

Embodiment 2

[0055] In a three-necked flask of 250ml, add 0.75g polylactic acid (D lactic acid mass content 4.25%, model is Ingeo TM Biopolymer 4043D), 1.25g hydroxypropyl cellulose (3~6mPa s, 2% aqueous solution at 20°C), 23.0g sulfolane (boiling point 285°C, 101.3kPa), heated to 80°C, and stirred at a speed of 450rpm until the polymer dissolves. Then 25 g of deionized water was added dropwise to the above system at a rate of 0.42 g / min. After the dropwise addition, the resulting suspension was filtered, washed with 100 g of deionized water, filtered, and the filtered product was vacuum-dried at 45° C. for 12 hours to obtain 0.65 g of white polylactic acid powder. Observation of the obtained powder with a scanning electron microscope showed an irregular porous structure ( figure 2 ), the volume average diameter is 3 μm, the particle size distribution index is 1.2, the porosity is 45%, and the oil absorption is 105mL / 100g.

Embodiment 3

[0057] In a three-necked flask of 250ml, add 2.00g polylactic acid (D lactic acid mass content 4.25%, model is Ingeo TM Biopolymer 4043D), 1.25g hydroxypropyl cellulose (3~6mPa·s, 2% aqueous solution at 20°C), 21.75g ​​diethylene glycol dimethyl ether (boiling point 162°C, 101.3kPa), heated to 80°C, And stir at a speed of 450rpm until the polymer dissolves. Then 25 g of deionized water was added dropwise to the above system at a rate of 0.42 g / min. After the dropwise addition was completed, the obtained suspension was filtered, washed with 100 g of deionized water, filtered, and the filtered product was vacuum-dried at 45° C. for 12 hours to obtain 1.85 g of white polylactic acid powder. Observation of the obtained powder with a scanning electron microscope showed a spherical porous structure with an average volume diameter of 82 μm, a particle size distribution index of 1.3, a porosity of 58%, and an oil absorption of 150 mL / 100 g.

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Abstract

The invention discloses porous polylactic acid particles and a preparation method thereof. The preparation method comprises the following steps: dissolving polylactic acid and an inducer in a high boiling solvent, carrying out solid-liquid separation with a precipitating agent, and drying to obtain the porous polylactic acid particles, wherein the high boiling solvent has higher boiling point than the precipitating agent, and the polylactic acid is polylactic acid of which the 1.2%<=D-lactic acid mass content or 1.2%<=L-lactic acid mass content is less than 11%. The method disclosed by the invention is convenient to operate, has the advantage of mild conditions, and can be used for preparing the porous polylactic acid particles with uniform particle size distribution by using a simple dissolution-precipitation process.

Description

technical field [0001] The invention belongs to a method for preparing porous polylactic acid particles, in particular to a method for preparing porous polylactic acid particles through a dissolution process and the porous polylactic acid particles prepared by the method. Background technique [0002] Polylactic acid is an excellent environment-friendly degradable polymer material with good biocompatibility and biodegradability. It undergoes enzymatic decomposition in the living body and finally forms carbon dioxide and water, which will not accumulate in vital organs. It is thus a suitable substrate for the preparation of microparticles. [0003] As the development technology of polylactic acid microparticles, it is currently mainly focused on the top-down process using polymer as the base material. This is mainly because the polymerization conditions of polylactic acid are relatively harsh, requiring vacuum and anhydrous, and the building-up process (building-up process),...

Claims

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Application Information

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IPC IPC(8): C08J9/00C08L67/04
Inventor 彭凯董雷张艳红欧阳芬
Owner TORAY FIBER RES INST(CHINA) CO LTD
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