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Preparation method of ultrafine porous calcium carbonate microsphere

A technology of porous calcium carbonate and microspheres, which is applied in the direction of calcium carbonate/strontium/barium, etc., can solve the problems of smooth surface of calcium carbonate microspheres and unsuitability for drug carriers, and achieve uniform size, spherical shape and wide application value Effect

Inactive Publication Date: 2015-01-28
SHAANXI UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Tang Hua et al. prepared calcium carbonate microspheres by adding templates to the precipitated calcium carbonate system. The obtained calcium carbonate was spherical and uniform, but the calcium carbonate microspheres had a smooth surface and were not suitable for drug carriers (Tang Hua, Zhang Du , Yang Xiaofei et al. A preparation method of calcium carbonate microspheres [P]. Chinese patent application number: 201210524831.X)

Method used

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  • Preparation method of ultrafine porous calcium carbonate microsphere
  • Preparation method of ultrafine porous calcium carbonate microsphere

Examples

Experimental program
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Effect test

Embodiment 1

[0032] 1) Dissolve the surfactant Tween-80 in the aqueous solution of n-hexane at a volume ratio of 4:100, and stir evenly with magnetic force at room temperature to obtain a mixed solution A; the volume fraction of n-hexane in the aqueous solution of n-hexane is 0.5% ;

[0033] 2) According to PVP and Na 2 CO 3 The molar ratio is 0.3:1, PVP is added to Na with a concentration of 1mol / L 2 CO 3 In the aqueous solution, stir magnetically at room temperature until the PVP is completely dissolved to obtain a mixed solution B;

[0034] 3) Add the mixed solution A to the mixed solution B, and ultrasonically emulsify with a power of 275W for 10 minutes to obtain an emulsion; the Na in the emulsion 2 CO 3 The concentration is 0.3mol / L;

[0035] 4) Under magnetic stirring, press Na 2 CO 3 with CaCl 2 The molar ratio is 2:3, and the emulsion that has just been ultrasonically emulsified is quickly poured into CaCl with a concentration of 0.15mol / L 2 In the aqueous solution, mag...

Embodiment 2

[0038] 1) Dissolve the surfactant Tween-80 in the aqueous solution of n-hexane at a volume ratio of 5:100, and stir evenly with magnetic force at room temperature to obtain a mixed solution A; the volume fraction of n-hexane in the aqueous solution of n-hexane is 0.8% ;

[0039] 2) According to PVP and Na 2 CO 3 The molar ratio of PVP is 0.15:1, and PVP is added to Na with a concentration of 0.5mol / L 2 CO 3 In the aqueous solution, stir magnetically at room temperature until the PVP is completely dissolved to obtain a mixed solution B;

[0040] 3) Add the mixed solution A to the mixed solution B, and ultrasonically emulsify with a power of 275W for 5 minutes to obtain an emulsion; the Na in the emulsion 2 CO 3 The concentration is 0.3mol / L;

[0041] 4) Under magnetic stirring, press Na 2 CO 3 with CaCl 2 The molar ratio is 2:3, and the emulsion that has just been ultrasonically emulsified is quickly poured into CaCl with a concentration of 0.2mol / L 2 In the aqueous s...

Embodiment 3

[0044] 1) Dissolve the surfactant Tween-80 in the aqueous solution of n-hexane at a volume ratio of 6:100, and stir evenly with magnetic force at room temperature to obtain a mixed solution A; the volume fraction of n-hexane in the aqueous solution of n-hexane is 1% ;

[0045] 2) According to PVP and Na 2 CO 3 The molar ratio of PVP is 0.75:1 and PVP is added to Na with a concentration of 1.5mol / L 2 CO 3 In the aqueous solution, stir magnetically at room temperature until the PVP is completely dissolved to obtain a mixed solution B;

[0046] 3) Add the mixed solution A to the mixed solution B, and ultrasonically emulsify for 20 minutes with a power of 275W to obtain an emulsion; the Na in the emulsion 2 CO 3 The concentration is 0.3mol / L;

[0047] 4) Under magnetic stirring, press Na 2 CO 3 with CaCl 2 The molar ratio is 2:3, and the emulsion that has just been ultrasonically emulsified is quickly poured into CaCl with a concentration of 0.1mol / L 2 In the aqueous sol...

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Abstract

The invention relates to a preparation method of an ultrafine porous calcium carbonate microsphere, which comprises the following steps: dissolving tween-80 in a n-hexane water solution, and uniformly stirring to obtain a mixed solution A; adding PVP (polyvinyl pyrrolidone) into a Na2CO3 water solution, and dissolving while stirring to obtain a mixed solution B; adding the mixed solution A into the mixed solution B, and performing ultrasonic emulsification to obtain an emulsion; pouring the emulsion into a CaCl2 water solution, and reacting while stirring to obtain a suspension; and standing the suspension, performing vacuum filtration, washing the filter cake, and drying to obtain the ultrafine porous calcium carbonate microsphere. According to the invention, the one-step synthesis of the ultrafine porous calcium carbonate microsphere is low in cost, simple in process, high in operability and suitable for large-scale industrial production. The prepared ultrafine porous calcium carbonate microsphere is round in sphericity, favorable in dispersity and uniform in size, and is a mixed crystal of vaterite and calcite, thus enlarging the application value thereof in the fields of controlled release systems, catalysis, fillers, biomedicine, new drug carriers and the like.

Description

technical field [0001] The invention belongs to the field of inorganic non-metallic materials, and in particular relates to a preparation method of ultrafine porous calcium carbonate microspheres. Background technique [0002] Calcium carbonate is a biomineral that exists widely in nature. It is also an industrial raw material with excellent performance and low price. Preparation of needle-shaped calcium carbonate from carbide slag [J]. Functional Materials, 2005,36(8):1238-1241.). Calcium carbonate is ABO 3 Its main crystal forms are calcite (rhomboid), aragonite (acicular), vaterite (spherical) (Yue Linhai, Jin Dalai, Xu Zhude. Co-precipitation method to synthesize composite calcium carbonate and its Research on morphology and crystal form [J]. Acta Chemie Sinica, 2003, 61(10): 1587-1591.). Calcium carbonate with different crystal forms and particle sizes has different application fields. Therefore, the research on controlling its crystal form and particle size by vario...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C01F11/18
Inventor 杨辉李欢
Owner SHAANXI UNIV OF SCI & TECH
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